Evidence map›Paper›PMID 31444905›Full record

ArticleThe Journal of physiology2019

Sodium-activated potassium channels moderate excitability in vascular smooth muscle.

Ping Li, Carmen M Halabi, Richard Stewart, Alice Butler, Bobbie Brown, Xiaoming Xia, Celia Santi, Sarah England, Juan Ferreira, Robert P Mecham and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. SLO3: A Conserved Regulator of Sperm Membrane Potential.International journal of molecular sciences · 2023
    Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Ping LiDepartment of Neuroscience.
Carmen M HalabiDepartment of Pediatrics.ORCID 0000-0003-4889-8131
Richard StewartDepartment of Neuroscience.
Alice ButlerDepartment of Neuroscience.
Bobbie BrownDepartment of Neuroscience.
Xiaoming XiaDepartment of Anesthesiology.
Celia SantiDepartment of Neuroscience.ORCID 0000-0002-5101-1303
Sarah EnglandDepartment of Obstetrics and Gynecology.
Juan FerreiraDepartment of Neuroscience.
Robert P MechamDepartment of Cell Biology and Physiology.
Lawrence SalkoffDepartment of Neuroscience.ORCID 0000-0001-7400-6550
Washington University in St. Louis · US

Funding

A NOVEL MOLECULAR MECHANISM FOR STIMULATING UTERINE CONTRACTILITY BY OXYTOCINR01HD088097 · NICHD · WASHINGTON UNIVERSITY · PI Sarah K. England, Celia M Santi · 2016 to 2026
$4.1M
ASSEMBLY OF LUNG ELASTINR01HL053325 · NHLBI · WASHINGTON UNIVERSITY · PI MECHAM, ROBERT P. · 1995 to 2019
$3.6M
VESSEL STIFFENING, HYPERTENSION, AND VASCULAR EXTRACELLULAR MATRIXR01HL105314 · NHLBI · WASHINGTON UNIVERSITY · PI MECHAM, ROBERT P., WAGENSEIL, JESSICA · 2010 to 2018
$3.2M
Testing a Novel Push-Pull Mechanism for Ca2+-Dependent Coupling in BK ChannelsR01GM114694 · NIGMS · WASHINGTON UNIVERSITY · PI MAGLEBY, KARL L, SALKOFF, LAWRENCE B · 2016 to 2019
$1.9M
Mutant Analysis of a Novel High Conductance K+ ChannelR01GM067154 · NIGMS · WASHINGTON UNIVERSITY · PI SALKOFF, LAWRENCE B · 2003 to 2006
$1.2M
SLO2 K+ CHANNELS: A MAJOR SYSTEM CONTROLLING EXCITABILITY IN THE BRAINR01NS061871 · NINDS · WASHINGTON UNIVERSITY · PI SALKOFF, LAWRENCE B · 2009 to 2010
$823k
Vascular Extracellular Matrix in Arterial Development and DiseaseK08HL135400 · NHLBI · WASHINGTON UNIVERSITY · PI HALABI, CARMEN M. · 2017 to 2020
$613k
ARE SODIUM-ACTIVATED POTASSIUM CHANNELS THE "GATE-KEEPERS" OF SYNAPTIC INTEGRATION?R21MH107955 · NIMH · WASHINGTON UNIVERSITY · PI SALKOFF, LAWRENCE B · 2015 to 2016
$419k
AN OVERLOOKED K+ CURRENT REPOLARIZES ACTION POTENTIALS THROUGHOUT THE BRAINR21NS088611 · NINDS · WASHINGTON UNIVERSITY · PI SALKOFF, LAWRENCE B · 2015 to 2016
$419k
NHLBI NIH HHS K08 HL135400NHLBI NIH HHS R01 HL053325NHLBI NIH HHS R01 HL105314NICHD NIH HHS R01 HD088097NIGMS NIH HHS R01 GM067154NIGMS NIH HHS R01 GM114694NIMH NIH HHS R21 MH107955NINDS NIH HHS R01 NS061871NINDS NIH HHS R21 NS088611
6 · The paper itself

Abstract

key pointsWe report that a sodium-activated potassium current, IK ABSTRACT: Although several potassium currents have been reported to play a role in arterial smooth muscle (ASM), we find that one of the largest contributors to membrane conductance in both conduit and resistance ASMs has been inadvertently overlooked. In the present study, we show that IK

Indexed as

Angiotensin IIAnimalsIntermediate-Conductance Calcium-Activated Potassium ChannelsMiceMice, KnockoutMuscle, Smooth, VascularPotassium Channels, Sodium-ActivatedRatsRats, Sprague-DawleyAngiotensin IIIntermediate-Conductance Calcium-Activated Potassium ChannelsPotassium Channels, Sodium-Activatedangiotensin IIKNa1.1KNa1.2persistent sodium currentpotassium channelSlo1Slo2.1vascular smooth muscle

Identifiers

PMID31444905
PMCPMC6800802
OpenAlexW2969734649

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.