Evidence map›Paper›PMID 31446830›Full record

ArticleChannels (Austin, Tex.)2019

Myrcene and terpene regulation of TRPV1.

C Jansen, L M N Shimoda, J K Kawakami, L Ang, A J Bacani, J D Baker, C Badowski, M Speck, A J Stokes, A L Small-Howard and 1 more

Open access · goldAbstract read
In one paragraph

Article in Channels (Austin, Tex.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Review
  7. Structural basis of the inhibition of TRPV1 by analgesic sesquiterpenes.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Effects of a Cannabinoid-Based Phytocomplex (Pain ReliefAnimals : an open access journal from MDPI · 2025
    Article
  12. Review
  13. Article
  14. Antimicrobial, Probiotic, and Immunomodulatory Potential ofAntibiotics (Basel, Switzerland) · 2024
    Article
  15. Review
  16. Plants (Basel, Switzerland) · 2023
    Review
  17. Review
  18. Review
  19. Secondary Terpenes inBiomedicines · 2022
    Review
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

C JansenLaboratory of Immunology and Signal Transduction, Chaminade University , Honolulu , HI , USA.
L M N ShimodaLaboratory of Immunology and Signal Transduction, Chaminade University , Honolulu , HI , USA.
J K KawakamiDepartment of Chemistry, Chaminade University , Honolulu , HI , USA.
L AngUndergraduate Program in Biology, Chaminade University , Honolulu , HI , USA.
A J BacaniUndergraduate Program in Biology, Chaminade University , Honolulu , HI , USA.
J D BakerDepartment of Biology, Chaminade University , Honolulu , HI , USA.
C BadowskiLaboratory of Experimental Medicine, John A. Burns School of Medicine , Honolulu , HI , USA.
M SpeckLaboratory of Immunology and Signal Transduction, Chaminade University , Honolulu , HI , USA.
A J StokesLaboratory of Experimental Medicine, John A. Burns School of Medicine , Honolulu , HI , USA.ORCID 0000-0002-3526-4685
A L Small-HowardGBSciences , Las Vegas , NV , USA.
H TurnerLaboratory of Immunology and Signal Transduction, Chaminade University , Honolulu , HI , USA.
Chaminade University of Honolulu · USUniversity of Hawaiʻi at Mānoa · US

Funding

UH Hilo COP A&RP20GM103466 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Peter R Hoffmann · 2012 to 2026
$60.3M
TRPA1 Physiology in Diabetes, Metabolic Syndrome, and MetabolismP20GM113134 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Kathryn Jaques Schunke · 2017 to 2026
$21.5M
RESEARCH DESIGN AND BIOSTATISTICS COREU54MD007584 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI HEDGES, JERRIS ROBERT, MOKUAU, NOREEN · 2012 to 2018
$21.1M
Chaminade University BRIC ProjectP20MD006084 · NIMHD · CHAMINADE UNIVERSITY OF HONOLULU · PI PLOEGER, BERNARD · 2010 to 2014
$4.0M
Mast Cell Responses to InsulinR15DK100978 · NIDDK · CHAMINADE UNIVERSITY OF HONOLULU · PI TURNER, HELEN C · 2015 to 2015
$431k
NIDDK NIH HHS R15 DK100978NIGMS NIH HHS P20 GM103466NIGMS NIH HHS P20 GM113134NIMHD NIH HHS P20 MD006084NIMHD NIH HHS U54 MD007584
6 · The paper itself

Abstract

Nociceptive Transient Receptor Potential channels such as TRPV1 are targets for treating pain. Both antagonism and agonism of TRP channels can promote analgesia, through inactivation and chronic desensitization. Since plant-derived mixtures of cannabinoids and the

Indexed as

Acyclic MonoterpenesAlkenesCalciumCannabinoidsCannabisCell LineHumansModels, MolecularMolecular Docking SimulationPlant ExtractsTerpenesTRPA1 Cation ChannelAcyclic MonoterpenesAlkenesCalciumCannabinoidsmyrcenePlant ExtractsTerpenesTRPA1 Cation Channelcalcium entryMyrcenepainterpenesTRPV1

Identifiers

PMID31446830
PMCPMC6768052
OpenAlexW2971195263

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.