ArticleArchives of medical sciences. Atherosclerotic diseases2019
Impaired vascular reactivity in sepsis - a systematic review with meta-analysis.
Article in Archives of medical sciences. Atherosclerotic diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Early passive mobilization increases vascular reactivity response in critical patients with sepsis: a quasi-experimental study.Revista Brasileira de terapia intensivaTrial
- Role of vascular smooth muscle cell pathobiology in sepsis‑induced vasoplegia (Review).International journal of molecular medicine · 2026Review
- ECMO in Refractory Septic Shock: Patient Selection, Timing and Hemodynamic Targets.Journal of clinical medicine · 2025Review
- Ultrasound-measured brachial artery reactive hyperemia in critically ill patients: an observational study.Critical care (London, England) · 2025Observational
- Long noncoding RNA MALAT1 can regulate proliferation and apoptosis of LPS-treated HK-2 cells via targeting miR-23a-3p through regulating ERK signaling.Archives of medical science : AMS · 2025Article
- Endothelial Injury-Induced Shedding of Thrombomodulin as a Biomarker for Predicting Adverse Prognosis in Sepsis.Journal of inflammation research · 2025Article
- Ultrasonographic assessment of brachial artery reactivity as a predictor of adverse outcome in patients undergoing emergency laparotomy for perforated peritonitis - Prospective observational study.Indian journal of anaesthesia · 2023Article
- Vascular Reactivity Index and PELOD-2 as a mortality predictor in paediatric septic shock: a single-centre retrospective study.BMJ paediatrics open · 2022Article
- High serum nitrates levels in non-survivor COVID-19 patients.Medicina intensiva · 2022Observational
- Case report: Temporal alterations in vascular function during the first 2 weeks of pediatric septic shock.Frontiers in pediatrics · 2022Article
- Machine learning applied to serum and cerebrospinal fluid metabolomes revealed altered arginine metabolism in neonatal sepsis with meningoencephalitis.Computational and structural biotechnology journal · 2021Article
- High serum nitrates levels in non-survivor COVID-19 patients.Medicina intensiva · 2020Article
- Serum vitamin D deficiency and risk of gestational diabetes mellitus: a meta-analysis.Archives of medical science : AMS · 2020Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionVascular dysfunction due to reduced nitric oxide bioavailability plays an important role in the pathogenesis of sepsis. This meta-analysis examines evidence from published literature to evaluate whether in the adult population the presence/severity of sepsis is associated with impaired vasoreactivity. MATERIAL AND
methodsWe performed a search of the Medline, Scopus, and EMBASE databases to identify observational studies using measurement of reactive hyperaemia in adult patients with sepsis. After data extraction using predefined protocol, qualitative synthesis of findings was performed regarding consistency of findings between methods, evidence of association between vascular reactivity and severity of sepsis, multiple organ failure, and death. A meta-analyses of standardised mean differences in vasoreactivity between groups was performed, in which data were available for relevant outcomes.
resultsEighteen studies using four methods to measure vascular reactivity from a total of 466 were included in the analysis. The pooled standardised mean difference estimate showed that septic patients had less reactive hyperaemia than controls (-2.59, 95% CI: -3.46 to -1.72;
conclusionsSeptic patients have attenuated vascular reactivity when compared to healthy volunteers. There are insufficient data indicating that these changes can identify patients at risk of worsening organ failure or death.
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