ArticleJournal of the Chinese Medical Association : JCMA2019
Progestin-primed ovarian stimulation improves the outcomes of IVF/ICSI cycles in infertile women with diminished ovarian reserve.
Article in Journal of the Chinese Medical Association : JCMA, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- A comparison of the effects of progestin-primed ovarian stimulation protocol and gonadotropin-releasing hormone antagonist protocol in assisted reproductive technology: a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2025Pooled it
- Impact of the PPOS protocol on euploidy embryo rates and reproductive outcomes in preimplantation genetic testing cycles: a systematic review.Frontiers in endocrinology · 2025Pooled it
- The clinical value of progestin-primed ovarian stimulation protocol for women with diminished ovarian reserve undergoing IVF/ICSI: a systematic review and meta-analysis.Frontiers in endocrinology · 2023Pooled it
- IVF Outcomes After PPOS Versus Flexible GnRH-Antagonist Protocol in Advanced-Age Women With Diminished Ovarian Reserve: A Retrospective Study.Health science reports · 2026Article
- The application of progesterone-primed ovarian stimulation protocol in patients with ovarian endometriosis combined with diminished ovarian reserve.BMC women's health · 2025Article
- Development and validation of a nomogram for failure to collect oocytes in POSEIDON Groups 3 and 4 undergoing IVF/ICSI treatment.Scientific reports · 2024Article
- Article
- Catalyzing IVF outcome prediction: exploring advanced machine learning paradigms for enhanced success rate prognostication.Frontiers in artificial intelligence · 2024Article
- Effect of medroxyprogesterone acetate dose in progestin-primed ovarian stimulation on pregnancy outcomes in poor ovarian response patients with different body mass index levels.Frontiers in endocrinology · 2024Article
- Progestin-Primed Ovarian Stimulation is a non-inferior alternative to the GnRH Antagonist Protocol in patients undergoing assisted reproductive techniques: a retrospective study.JBRA assisted reproduction · 2022Article
- Which Factors Are Associated With Reproductive Outcomes of DOR Patients in ART Cycles: An Eight-Year Retrospective Study.Frontiers in endocrinology · 2022Article
- Progestin-Primed Ovarian Stimulation Protocol for Patients With Endometrioma.Frontiers in endocrinology · 2022Article
- Is modified embryo transfer technique related to an increased pregnancy rate?Journal of the Chinese Medical Association : JCMA · 2021Article
- Co-Administration of Clomiphene Citrate and Letrozole in Mild Ovarian Stimulation Versus Conventional Controlled Ovarian Stimulation Among POSEIDON Group 4 Patients.Frontiers in endocrinology · 2021Article
- Progestin-Primed Ovarian Stimulation Versus Mild Stimulation Protocol in Advanced Age Women With Diminished Ovarian Reserve Undergoing Their FirstFrontiers in endocrinology · 2021Article
- Progestin-Primed Ovarian Stimulation with Clomiphene Citrate Supplementation May Be More Feasible for Young Women with Diminished Ovarian Reserve Compared with Standard Progestin-Primed Ovarian Stimulation: A Retrospective Study.Drug design, development and therapy · 2021Article
- AMH has no role in predicting oocyte quality in women with advanced age undergoing IVF/ICSI cycles.Scientific reports · 2020Article
- Enhancement of outcome in women with poor ovarian responses.Journal of the Chinese Medical Association : JCMA · 2020Article
- Chlormadinone acetate in progestin-primed ovarian stimulation does not negatively affect clinical results.Reproductive medicine and biologyArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOvarian stimulation with clomiphene (CC) or progestin has been applied for patients with diminished ovarian reserve (DOR). However, it remains unclear which treatment confers greater benefits. This study aimed to compare the outcomes of progestin-primed ovarian stimulation (PPOS) protocol vs CC-primed ovarian stimulation (CPOS) in infertile women with DOR.
methodsA before-and-after self-controlled study was conducted to retrospectively investigate the data from 50 infertile women with DOR, who failed to conceive in their first in vitro fertilization/intracytoplasmic sperm injection-frozen embryo transfer cycle when stimulated with CPOS, and switched to PPOS, in the Reproductive Medicine Center of Changzhou Maternal and Child Health Care Hospital.
resultsOur results showed that PPOS significantly suppressed the luteinizing hormone (LH) surge and yielded more satisfactory results in patients with DOR, including increased number of retrieved oocytes, MII mature oocytes, normal fertilized oocytes, cleaved embryos, high-grade embryos, cryopreserved embryos, pregnancy rate, live-birth rate, and decreased miscarriage rates.
conclusionOur study demonstrated that compared with CPOS protocol, PPOS protocol could not only suppress the LH surge but also improved the quantity, particularly the quality of oocytes in patients with DOR, suggesting that PPOS treatment is more effective than CPOS for patients with DOR.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.