Evidence map›Paper›PMID 31454102›Full record

ArticleJournal of clinical laboratory analysis2019

Association between the TOX3 rs3803662 C>T polymorphism and recurrent miscarriage in a southern Chinese population.

Wendong Huang, Huazhong Zhou, Qisen Li, Lei Pi, Yufen Xu, LanYan Fu, Yanfang Yang, Zhaoliang Lu, Di Che, Xiaoqiong Gu

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In one paragraph

Article in Journal of clinical laboratory analysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Wendong HuangResearch Center, Maoming People's Hospital, Guangdong, China.
Huazhong ZhouDepartment of Clinical Biological Resource Bank, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Qisen LiResearch Center, Maoming People's Hospital, Guangdong, China.
Lei PiDepartment of Clinical Biological Resource Bank, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Yufen XuDepartment of Clinical Biological Resource Bank, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
LanYan FuDepartment of Clinical Biological Resource Bank, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Yanfang YangDepartment of Prenatal Diagnosis, Maoming People's Hospital, Maoming, Guangdong, China.
Zhaoliang LuDepartment of Clinical Biological Resource Bank, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Di CheDepartment of Clinical Biological Resource Bank, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0002-0209-6961
Xiaoqiong GuDepartment of Clinical Biological Resource Bank, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.

Funding

Guangdong Natural Science Fund 2016A030313836Guangzhou Medical and Health Technology Projects, China 20171A011260Guangzhou Medical and Health Technology Projects, China 20191A011021Guangzhou Medical and Health Technology Projects, China 20191A011033Guangzhou Science and Technology Program Project, China 201607010011Guangzhou Science and Technology Program Project, China 201804010035Technology Program Project,China 201607010011Technology Program Project,China 201804010035Technology Program Project,China 201904010486
6 · The paper itself

Abstract

backgroundStudies have shown that some genetic polymorphisms associated with breast cancer susceptibility may also be associated with abortion. The TOX3 gene plays a key role during the onset of breast cancer, and reproductive factors such as abortion are risk factors for breast cancer. However, there is currently no study describing the relationship between the TOX3 rs3803662 C>T polymorphism and the risk of recurrent miscarriage. Therefore, we investigated whether the TOX3 rs3803662 C>T polymorphism is associated with recurrent miscarriage susceptibility in this case-control study.

methodsWe recruited 248 recurrent miscarriage patients and 392 healthy controls from the southern Chinese population and performed genotyping using the TaqMan method.

resultsThe results showed no evidence that TOX3 rs3803662 C>T is associated with recurrent miscarriage (CT and CC: corrected OR = 1.038, 95% CI = 0.737-1.461, P = .8321; TT and CC: adjusted OR = 0.989, 95% CI = 0.591-1.656, P = .9659; dominant model: adjusted OR = 1.027, 95% CI = 0.742-1.423, P = .8712; recessive model: adjusted OR = 0.969, 95% CI = 0.600-1.566, P = .8975).

conclusionAccording to this study, the TOX3 rs3803662 C>T polymorphism may not be associated with recurrent miscarriage in the southern Chinese population. A larger multicenter study is needed to confirm the results.

Indexed as

Genetic Association StudiesGenetic Predisposition to DiseaseAbortion, HabitualAdultApoptosis Regulatory ProteinsAsian PeopleCase-Control StudiesFemaleGene FrequencyHumansPolymorphism, Single NucleotidePregnancyTrans-ActivatorsYoung AdultApoptosis Regulatory ProteinsTOX3 protein, humanTrans-Activatorsgenetic susceptibilityrecurrent miscarriagers3803662TOX3 gene

Identifiers

PMID31454102
PMCPMC6868414

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.