Evidence map›Paper›PMID 31463398›Full record

ArticleHeliyon2019

Insulin attenuates apoptosis in neuronal cells by an integrin-linked kinase-dependent mechanism.

Jacqueline Tan, Murat Digicaylioglu, Stacy X J Wang, Jonathan Dresselhuis, Shoukat Dedhar, Julia Mills

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Integrin-linked kinase (ILK): the known vs. the unknown and perspectives.Cellular and molecular life sciences : CMLS · 2022
    Review
  3. The female syndecan-4Frontiers in cell and developmental biology · 2022
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Jacqueline TanDepartment of Biology, Trinity Western University, Langley, British Columbia, Canada.
Murat DigicayliogluDepartments of Neurosurgery and Physiology, Scripps Research, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Stacy X J WangDepartment of Biology, Trinity Western University, Langley, British Columbia, Canada.
Jonathan DresselhuisDepartment of Biology, Trinity Western University, Langley, British Columbia, Canada.
Shoukat DedharDepartment of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.
Julia MillsDepartment of Biology, Trinity Western University, Langley, British Columbia, Canada.
Western University · CAScripps Institution of Oceanography · USUniversity of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Insulin promotes neuronal survival by activating a phosphatidylinositol 3-kinase (PI 3-kinase)/AKT-dependent signaling pathway and reducing caspase activation. We investigated a role for integrin-linked kinase (ILK) in insulin-mediated cell survival in cultured neurons and differentiated R28 cells. We used a serum and depolarization withdrawal model to induce apoptosis in cerebellar granule neurons and a serum withdrawal model to induce apoptosis in differentiated R28 cells. ILK knock-out decreased insulin-mediated protection as did the addition of pharmacological inhibitors of ILK, KP-392 or QLT-0267. Prosurvival effects of insulin were rescued by Boc-Asp (O-methyl)-CH

Indexed as

Cell biologyDevelopmental biologyDiabetesIGF-1Inhibitor of apoptosisInsulinIntegrinIntegrin-linked kinaseMetabolic disorderNervous systemNeuroscienceSerum and depolarization withdrawal

Identifiers

PMID31463398
PMCPMC6706370
OpenAlexW2966965288

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.