ArticleDiabetes research and clinical practice2020
Regression from prediabetes to normal glucose levels is more frequent than progression towards diabetes: The CRONICAS Cohort Study.
Article in Diabetes research and clinical practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
- Prevention of type 2 diabetes through prediabetes remission without weight loss.Nature medicine · 2025Trial
- A predictive study of glycaemic reversal in Chinese individuals with prediabetes based on machine learning: a 5-year cohort study.Frontiers in endocrinology · 2026Article
- Predictive value of MetS-IR for the glucose status conversion in prediabetes: a multi-center retrospective cohort study.BMC endocrine disorders · 2025Article
- Prevalence and incidence of prediabetes in Latin America. A systematic review and meta-analysis.Journal of diabetes and metabolic disorders · 2025Article
- Nonlinear relationship between hepatic steatosis index and reversion to normal glucose regulation in Chinese adults with prediabetes.Scientific reports · 2025Article
- Association between the aspartate aminotransferase-to-alanine aminotransferase ratio and the reversion to normoglycemia in people with impaired fasting glucose: a 5-year retrospective cohort study.Frontiers in endocrinology · 2025Article
- Progression to diabetes and regression to normoglycemia in pre-diabetic subjects: results from a pragmatic community trial in a middle-income country.Journal of diabetes and metabolic disorders · 2024Article
- Link between remnant cholesterol and the reversion to normoglycemia in Chinese adults with prediabetes: a 5-year cohort study.Scientific reports · 2024Article
- Sex differences in the association between metabolic score for insulin resistance and the reversion to normoglycemia in adults with prediabetes: a cohort study.Diabetology & metabolic syndrome · 2024Article
- Association between estimated glomerular filtration rate and reversion to normoglycemia in people with impaired fasting glucose: a 5-year retrospective cohort study.European journal of medical research · 2024Article
- Association between high-density lipoprotein cholesterol and reversion to normoglycemia from prediabetes: an analysis based on data from a retrospective cohort study.Scientific reports · 2024Article
- Glucose metabolism disorders and changes in cardiovascular risk among adult Peruvian population.Wellcome open research · 2024Article
- Article
- Elevated triglyceride-glucose-body mass index associated with lower probability of future regression to normoglycemia in Chinese adults with prediabetes: a 5-year cohort study.Frontiers in endocrinology · 2024Article
- Association between non-high-density lipoprotein to high-density lipoprotein ratio and reversion to normoglycemia in people with impaired fasting glucose: a 5-year retrospective cohort study.Diabetology & metabolic syndrome · 2023Article
- Triglyceride to high-density lipoprotein cholesterol ratio is associated with regression to normoglycemia from prediabetes in adults: a 5-year cohort study in China.Journal of translational medicine · 2023Article
- Prediabetes Progression and Regression on Objectively- Measured Physical Function: A Prospective Cohort Study.Diabetes & metabolism journal · 2023Article
- Association between body mass index and reversion to normoglycemia from impaired fasting glucose among Chinese adults: a 5-year cohort study.Frontiers in endocrinology · 2023Article
- Metabolomic markers of glucose regulation after a lifestyle intervention in prediabetes.BMJ open diabetes research & care · 2022Article
- Poor Eating Behaviors Related to the Progression of Prediabetes in a Japanese Population: An Open Cohort Study.International journal of environmental research and public health · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
aimsThis study aimed to (1) estimate the prevalence of prediabetes according to different definitions, (2) evaluate regression to normal glucose levels and progression towards T2DM, and (3) determine factors associated with regression and progression across four diverse geographical settings in a Latin American country.
methodsThe CRONICAS Cohort Study was conducted in four different areas in Peru. Enrollment started in September 2010 and follow-up was conducted in 2013. Prediabetes, T2DM and normal glucose levels were determined according to definitions from the World Health Organization (WHO), American Diabetes Association (ADA), and National Institute for Health and Care Excellence (NICE). The main outcomes were regression to normal glucose levels and incidence of T2DM. Prevalence estimates and 95% confidence intervals (95% CI) were calculated. Crude and adjusted models using Poisson regression were performed and relative risk ratios (RRR) and 95% CI were calculated.
resultsAt baseline, the prevalence of prediabetes varied markedly by definition used: 6.5%(95% CI 5.6-7.6%), 53.6% (95% CI 51.6-55.6%), and 24.6% (95% CI 22.8-26.4%) according to WHO, ADA and NICE criteria, respectively. After 2.2 years of follow-up, in those with prediabetes, the cumulative incidence of regression to euglycemia ranged between 31.4% and 68.9%, whereas the incidence of T2DM varied from 5.5% to 28.8%. Factors associated with regression to normal glucose levels and progression to diabetes were age, body mass index, and insulin resistance.
conclusionsRegression from pre-diabetes back to euglycemia was much more common than progression to diabetes.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.