Evidence map›Paper›PMID 31466086›Full record

ArticleThrombosis and haemostasis2019

Fibrin-VLDL Receptor-Dependent Pathway Promotes Leukocyte Transmigration by Inhibiting Src Kinase Fyn and is a Target for Fibrin β15-42 Peptide.

Sergiy Yakovlev, Chunzhang Cao, Rebeca Galisteo, Li Zhang, Dudley K Strickland, Leonid Medved

Open access · greenAbstract read
In one paragraph

Article in Thrombosis and haemostasis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  10. Illustrated State-of-the-Art Capsules of the ISTH 2020 Congress.Research and practice in thrombosis and haemostasis · 2021
    Review
  11. Review
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sergiy YakovlevCenter for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, Maryland, United States.
Chunzhang CaoCenter for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, Maryland, United States.
Rebeca GalisteoCenter for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, Maryland, United States.
Li ZhangCenter for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, Maryland, United States.
Dudley K StricklandCenter for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, Maryland, United States.
Leonid MedvedCenter for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, Maryland, United States.
University of Maryland, Baltimore · US

Funding

FIBRIN(OGEN) STRUCTURE AND INTERACTIONSR01HL056051 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI LEONID V. MEDVED · 1998 to 2026
$9.1M
Role of LDL receptor family members in protecting the vasculatureR35HL135743 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI STRICKLAND, DUDLEY K. · 2017 to 2023
$5.4M
Mac-1 coordinates PDGF-CC activation by microglia and promotes BBB openingR01NS082607 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI ZHANG, LI · 2013 to 2017
$1.7M
NHLBI NIH HHS R01 HL056051NHLBI NIH HHS R35 HL135743NINDS NIH HHS R01 NS082607
6 · The paper itself

Abstract

According to the current view, binding of fibrin degradation product E

Indexed as

AnimalsAntigens, CDCadherin 5CadherinsCoculture TechniquesDisease Models, AnimalEndothelial CellsFemaleFibrin Fibrinogen Degradation ProductsHL-60 CellsHumansHuman Umbilical Vein Endothelial CellsLeukocytesMaleMice, Inbred C57BLMice, KnockoutAntigens, CDCadherin 5CadherinsFibrin Fibrinogen Degradation Productsfibrinogen Bbeta (15-42)FYN protein, humanFyn protein, mousePeptide FragmentsProto-Oncogene Proteins c-fynReceptors, LDLVLDL receptor

Identifiers

PMID31466086
PMCPMC7179994
OpenAlexW2970652951

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.