Evidence map›Paper›PMID 31469946›Full record

ReviewCellular microbiology2020

Plasmodium vivax Reticulocyte Binding Proteins for invasion into reticulocytes.

Li-Jin Chan, Melanie H Dietrich, Wang Nguitragool, Wai-Hong Tham

Open access · hybridAbstract readReview
In one paragraph

Review in Cellular microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Tropical medicine and infectious disease · 2023
    Review
  11. Expression, Purification, and Characterization ofInternational journal of molecular sciences · 2023
    Article
  12. Review
  13. Evolution ofLe infezioni in medicina · 2023
    Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Band 3-mediatedFrontiers in cellular and infection microbiology · 2022
    Article
  19. Frontiers in immunology · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Li-Jin ChanThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Melanie H DietrichThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Wang NguitragoolDepartment of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Wai-Hong ThamThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.ORCID 0000-0001-7950-8699
The University of Melbourne · AUMahidol University · TH

Funding

Wellcome TrustWellcome Trust 208693/Z/17/Z
6 · The paper itself

Abstract

Plasmodium vivax is responsible for most of the malaria infections outside Africa and is currently the predominant malaria parasite in countries under elimination programs. P. vivax preferentially enters young red cells called reticulocytes. Advances in understanding the molecular and cellular mechanisms of entry are hampered by the inability to grow large numbers of P. vivax parasites in a long-term in vitro culture. Recent progress in understanding the biology of the P. vivax Reticulocyte Binding Protein (PvRBPs) family of invasion ligands has led to the identification of a new invasion pathway into reticulocytes, an understanding of their structural architecture and PvRBPs as targets of the protective immune response to P. vivax infection. This review summarises current knowledge on the role of reticulocytes in P. vivax infection, the function of the PvRBP family of proteins in generating an immune response in human populations, and the characterization of anti-PvRBP antibodies in blocking parasite invasion.

Indexed as

Antibodies, ProtozoanHumansMalaria, VivaxMembrane ProteinsPlasmodium vivaxProtein BindingProtozoan ProteinsReticulocytesAntibodies, ProtozoanMembrane ProteinsProtozoan Proteinsreticulocyte-binding protein, Plasmodium vivaxantibodieshost-pathogen interactionsPlasmodium falciparumPlasmodium vivaxstructure biology

Identifiers

PMID31469946
PMCPMC7003471
OpenAlexW2970294782

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.