Evidence map›Paper›PMID 31470621›Full record

ReviewPharmacy (Basel, Switzerland)2019

Polypharmacy Definitions for Multimorbid Older Adults Need Stronger Foundations to Guide Research, Clinical Practice and Public Health.

Caroline Sirois, Nelia Sofia Domingues, Marie-Laure Laroche, Arsène Zongo, Carlotta Lunghi, Line Guénette, Edeltraut Kröger, Valérie Émond

Registry-linked trialAbstract readReview
In one paragraph

Review in Pharmacy (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04663360 (Medication Monitoring in General Practice), which is not on this map. Cited by 48 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04663360 nacompletednot on this mapstarted 2020, after this paper: background citation

Medication Monitoring in General Practice: Clinical Impact of Implementing a Nurse-led Adverse Drug Reaction (ADRe) Profile in Older Adults With 5 or More Prescribed Medicines

TypeinterventionalSponsorSwansea UniversityRan2020 to 2020Enrolled19ConditionsPolypharmacyArmsAdverse Drug Reaction (ADRe) Profile
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  8. Polypharmacy Thresholds that Best Predict Emergency Room Visits and Mortality in Older Adults: A Population-Based Study in Québec, Canada.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Caroline SiroisDepartment of Social and Preventive Medicine, Faculty of Medicine, Laval University, Québec, QC G1V 0A6, Canada. caroline.sirois@fmed.ulaval.ca.ORCID 0000-0003-3294-7883
Nelia Sofia DominguesCentre de Recherche sur les Soins et les Services de Première Ligne de L'Université Laval, Québec, QC G1J 0A4, Canada.
Marie-Laure LarocheService de Pharmacologie, Toxicologie et Pharmacovigilance, Centre Régional de Pharmacovigilance, de Pharmacoépidémiologie et D'information sur les Médicaments, Centre Hospitalier Universitaire de Limoges, 87042 Limoges, France.ORCID 0000-0003-4344-0359
Arsène ZongoFaculty of Pharmacy, Université Laval, Québec, QC G1V 0A6, Canada.
Carlotta LunghiSanté des Populations et Pratiques Optimales en Santé, Centre de Recherche du CHU de Québec, Québec, QC G1S 4L8, Canada.ORCID 0000-0001-7636-6285
Line GuénetteCentre de Recherche sur les Soins et les Services de Première Ligne de L'Université Laval, Québec, QC G1J 0A4, Canada.ORCID 0000-0001-9769-7550
Edeltraut KrögerCentre of Excellence on Aging of Quebec, CIUSSS-CN, Québec, QC G1S 4L8, Canada.
Valérie ÉmondInstitut National de Santé Publique du Québec, Québec, QC G1V 5B3, Canada.

Funding

Canadian Institute for Health Research Knowledge Synthesis Grant
6 · The paper itself

Abstract

There are numerous definitions of polypharmacy to describe the use of many medications among older adults, but there is a need to clarify if they are purposive and meaningful. By means of a systematic review, we identified definitions of polypharmacy used in multimorbid older adults (≥65 years). We evaluated if the definitions align among the domains of research, clinical practice, and public health and appraised whether concepts of polypharmacy are based on strong foundations. More than 46 definitions of polypharmacy were retrieved from 348 publications (research:

Indexed as

clinical practicemedicationsmultimorbidityolder adultspolypharmacypopulation healthresearchscoping review

Identifiers

PMID31470621
PMCPMC6789889

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.