Evidence map›Paper›PMID 31471206›Full record

ArticleAcademic radiology2020

Ventilation Heterogeneity and Its Association with Nodule Formation Among Participants in the National Lung Screening Trial-A Preliminary Investigation.

David A Kaminsky, Nirav Daphtary, Raul S J Estepar, Taka Ashikaga, Lukas Mikulic, Jeffrey Klein, C Matthew Kinsey

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In one paragraph

Article in Academic radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

David A KaminskyVermont Lung Center, University of Vermont Larner College of Medicine, 89 Beaumont Avenue, Burlington, VT. Electronic address: david.kaminsky@uvm.edu.
Nirav DaphtaryVermont Lung Center, University of Vermont Larner College of Medicine, 89 Beaumont Avenue, Burlington, VT.
Raul S J EsteparApplied Chest Imaging Laboratory, Brigham and Women's Hospital, Boston, Massachusetts.
Taka AshikagaMedical Biostatistics, University of Vermont, Burlington, Vermont.
Lukas MikulicVermont Lung Center, University of Vermont Larner College of Medicine, 89 Beaumont Avenue, Burlington, VT.
Jeffrey KleinDepartment of Radiology, McClure 1, University of Vermont Medical Center, Burlington, Vermont.
C Matthew KinseyVermont Lung Center, University of Vermont Larner College of Medicine, 89 Beaumont Avenue, Burlington, VT.

Funding

Using Dengue Controlled Human Infection Model to Identify Adaptive Immune Correlates of ProtectionP20GM125498 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Beth Diane Kirkpatrick · 2018 to 2026
$24.9M
The clinical impact of pulmonary vascular remodeling in smokersR01HL116473 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SAN JOSE ESTEPAR, RAUL, WASHKO, GEORGE R · 2013 to 2021
$5.0M
Airway Inspector: a chest imaging biomarker software platform for COPDR01HL116931 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SAN JOSE ESTEPAR, RAUL · 2013 to 2017
$2.2M
CT Characteristics of Emphysema for Evaluation of Pulmonary NodulesK23HL133476 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI KINSEY, CHARLES MATTHEW · 2016 to 2021
$933k
NHLBI NIH HHS K23 HL133476NHLBI NIH HHS R01 HL116473NHLBI NIH HHS R01 HL116931NIGMS NIH HHS P20 GM125498
6 · The paper itself

Abstract

RATIONALE AND

objectivesWe have developed a technique to measure ventilation heterogeneity (VH) on low dose chest CT scan that we hypothesize may be associated with the development of lung nodules, and perhaps cancer. If true, such an analysis may improve screening by identifying regional areas of higher risk. MATERIALS AND

methodsUsing the National Lung Screening Trial database, we identified a small subset of those participants who were labeled as having a positive screening test at 1 year (T1) but not at baseline (T0). We isolated the region in which the nodule would form on the T0 scan ("target region") and measured VH as the standard deviation of the linear dimension of a virtual cubic airspace based on measurement of lung attenuation within the region.

resultsWe analyzed 24 cases, 9 with lung cancer and 15 with a benign nodule. We found that the VH of the target region was nearly statistically greater than that of the corresponding contralateral control region (0.168 [0.110-0.226] vs. 0.112 [0.083-0.203], p = 0.051). The % emphysema within the target region was greater than that of the corresponding contralateral control region (1.339 [0.264-4.367] vs. 1.092 [0.375-4.748], p = 0.037). There was a significant correlation between the % emphysema and the VH of the target region (rho = +0.437, p = 0.026).

conclusionOur study provides the first data in support of increased local VH being associated with subsequent lung nodule formation. Further work is necessary to determine whether this technique can enhance screening for lung cancer by low dose chest CT scan.

Indexed as

AdultEarly Detection of CancerFemaleHumansLungLung NeoplasmsMaleMass ScreeningMiddle AgedRetrospective StudiesTomography, X-Ray ComputedLinear airspace dimensionLow dose chest CTLung cancerNational Lung Screening TrialVentilation heterogeneity

Identifiers

PMID31471206
PMCPMC7243969

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.