Evidence map›Paper›PMID 31473403›Full record

ArticleThrombosis research2019

Prospective study of plasma high molecular weight kininogen and prekallikrein and incidence of coronary heart disease, ischemic stroke and heart failure.

Romil R Parikh, Aaron R Folsom, Jeffrey R Misialek, Wayne D Rosamond, Patricia P Chang, Weihong Tang, Mary Cushman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thrombosis research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Romil R ParikhDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 South 3nd Street, Suite 300, Minneapolis, MN 55454, United States. Electronic address: parik075@umn.edu.
Aaron R FolsomDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 South 3nd Street, Suite 300, Minneapolis, MN 55454, United States. Electronic address: folso001@umn.edu.
Jeffrey R MisialekDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 South 3nd Street, Suite 300, Minneapolis, MN 55454, United States. Electronic address: misi0020@umn.edu.
Wayne D RosamondDepartment of Epidemiology, University of North Carolina, 137 East Franklin Street, Suite 306, CB# 7435, Chapel Hill, NC 27514, United States. Electronic address: wayne_rosamond@unc.edu.
Patricia P ChangDivision of Cardiology, Department of Medicine, University of North Carolina, 300 Meadowmont Village Cir #104, Chapel Hill, NC 27517, United States. Electronic address: patricia_chang@med.unc.edu.
Weihong TangDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 South 3nd Street, Suite 300, Minneapolis, MN 55454, United States. Electronic address: tang0097@umn.edu.
Mary CushmanDepartment of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Main Pavilion, 111 Colchester Ave, Burlington, VT 05401, United States; Department of Medicine, University of Vermont College of Medicine, Main Pavilion, 111 Colchester Ave, Burlington, VT 05401, United States. Electronic address: Mary.Cushman@uvm.edu.
University of Minnesota · USUniversity of North Carolina at Chapel Hill · USUniversity of Vermont · US

Funding

EPIDEMIOLOGY OF VENOUS THROMBOSIS AND PULMONARY EMBOLISMR01HL059367 · UNIVERSITY OF MINNESOTA TWIN CITIES · 1998 to 2005
$1.9M
NHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INHLBI NIH HHS R01 HL059367
6 · The paper itself

Abstract

introductionHigh molecular weight kininogen (HK) and prekallikrein (PK) are proteins in the kallikrein/kinin system of the coagulation cascade. They play an important role in the contact activation system of the intrinsic coagulation pathway, renin-angiotensin activation, and inflammation. Hence these proteins have been posited to affect the occurrence of cardiovascular events and thus to be potential therapeutic targets. Previous case-control studies have provided inconsistent evidence for an association of HK and PK with cardiovascular disease.

methodsIn the prospective population-based Atherosclerosis Risk in Communities(ARIC) Study, we used Cox proportional hazards regression models to investigate the association in 4195 middle-aged adults of plasma HK and PK concentrations in 1993-95 (linearly and in quartiles) with incident coronary heart disease, ischemic stroke, and heart failure through 2016.

resultsOver a mean of 18 years follow-up, we identified incident cardiovascular events (coronary heart disease and ischemic stroke) in 618 participants and heart failure in 667. We observed no significant relation between HK or PK and cardiovascular disease or heart failure, before and after adjusting for several potential confounding variables.

conclusionsWe found no compelling evidence to support an association of plasma HK or PK concentrations with incident CHD, ischemic stroke, or heart failure.

Indexed as

Brain IschemiaCoronary DiseaseFemaleHeart FailureHumansIncidenceKininogen, High-Molecular-WeightMaleMiddle AgedPrekallikreinProspective StudiesStrokeKininogen, High-Molecular-WeightPrekallikreinCardiovascular diseaseHeart failureHigh molecular weight kininogenIschemic strokePrekallikreinProspective study

Identifiers

PMID31473403
PMCPMC6825898
OpenAlexW2969666421

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.