Evidence map›Paper›PMID 31478326›Full record

SynthesisObesity reviews : an official journal of the International Association for the Study of Obesity2019

Gene-lifestyle interaction on risk of type 2 diabetes: A systematic review.

Stefan Dietrich, Simone Jacobs, Ju-Sheng Zheng, Karina Meidtner, Lukas Schwingshackl, Matthias B Schulze

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Obesity reviews : an official journal of the International Association for the Study of Obesity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 14 syntheses or guidelines pooled it.

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  3. Polygenic Risk and Nutrient Intake Interactions on Obesity Outcomes: A Systematic Review and Meta-Analysis of Observational Studies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
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  14. Gene-lifestyle interaction on risk of type 2 diabetes: A systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Stefan DietrichDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany.ORCID 0000-0002-3260-1818
Simone JacobsDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany.
Ju-Sheng ZhengMRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Karina MeidtnerDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany.
Lukas SchwingshacklInstitute for Evidence in Medicine, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.ORCID 0000-0003-3407-7594
Matthias B SchulzeDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany.ORCID 0000-0002-0830-5277

Funding

Medical Research Council MC_UU_12015/5
6 · The paper itself

Abstract

The pathophysiological influence of gene-lifestyle interactions on the risk to develop type 2 diabetes (T2D) is currently under intensive research. This systematic review summarizes the evidence for gene-lifestyle interactions regarding T2D incidence. MEDLINE, EMBASE, and Web of Science were systematically searched until 31 January 2019 to identify publication with (a) prospective study design; (b) T2D incidence; (c) gene-diet, gene-physical activity, and gene-weight loss intervention interaction; and (d) population who are healthy or prediabetic. Of 66 eligible publications, 28 reported significant interactions. A variety of different genetic variants and dietary factors were studied. Variants at TCF7L2 were most frequently investigated and showed interactions with fiber and whole grain on T2D incidence. Further gene-diet interactions were reported for, eg, a western dietary pattern with a T2D-GRS, fat and carbohydrate with IRS1 rs2943641, and heme iron with variants of HFE. Physical activity showed interaction with HNF1B, IRS1, PPARγ, ADRA2B, SLC2A2, and ABCC8 variants and weight loss interventions with ENPP1, PPARγ, ADIPOR2, ADRA2B, TNFα, and LIPC variants. However, most findings represent single study findings obtained in European ethnicities. Although some interactions have been reported, their conclusiveness is still low, as most findings were not yet replicated across multiple study populations.

Indexed as

Body Mass IndexDiabetes Mellitus, Type 2Diet, HealthyDiet, WesternEthnicityGene-Environment InteractionGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyHumansPolymorphism, Single NucleotideProspective StudiesTranscription Factor 7-Like 2 ProteinTranscription Factor 7-Like 2 Proteindietgene-lifestyle interactionincident type 2 diabetesphysical activityweight loss intervention

Identifiers

PMID31478326
PMCPMC8650574

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.