Polymorphisms in PCSK9, LDLR, BCMO1, SLC12A3, and KCNJ1 are Associated with Serum Lipid Profile in Chinese Han Population.

Zheng Li, Tianyu Zhao, Xiaohua Tan, Song Lei, Liu Huang, Lei Yang

Open access · goldFull text read

In one paragraph

Article in International journal of environmental research and public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

1.1field-weighted citation impact, top 22% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

Update of a Genetic Risk Score Predictive of the Plasma Triglyceride Response to an Omega-3 Fatty Acid Supplementation in the FAS Study.Nutrients · 2023
Article
Association of genetic polymorphisms of PCSK9 with type 2 diabetes in Uygur Chinese population.BMC cardiovascular disorders · 2022
Article
Effects of Erchen Decoction on Oxidative Stress-Related Cytochrome P450 Metabolites of Arachidonic Acid in Dyslipidemic Mice with Phlegm-Dampness Retention Syndrome: A Randomized, Controlled Trial on the Correspondence between Prescription and Syndrome.Evidence-based complementary and alternative medicine : eCAM · 2022
Article
Study on the Effect of Macrophages on Vascular Endothelium in Mice With Different TCM Syndromes of Dyslipidemia and its Biological Basis Based on RNA-Seq Technology.Frontiers in pharmacology · 2021
Article
The c.*52Biomolecules · 2020
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Zheng LiMedical School, Hangzhou Normal University, Hangzhou 310000, China.

Tianyu ZhaoMedical School, Hangzhou Normal University, Hangzhou 310000, China.ORCID 0000-0002-4424-7959

Xiaohua TanMedical School, Hangzhou Normal University, Hangzhou 310000, China.ORCID 0000-0002-3864-5301

Song LeiMedical School, Hangzhou Normal University, Hangzhou 310000, China.

Liu HuangMedical School, Hangzhou Normal University, Hangzhou 310000, China.

Lei YangMedical School, Hangzhou Normal University, Hangzhou 310000, China. yanglei62@hznu.edu.cn.

Hangzhou Normal University · CNShihezi University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Unfavorable serum lipid levels are the most important risk factors for coronary artery disease (CAD), cerebral infarction, and other cardiovascular and cerebrovascular diseases. This study included 2323 Han Chinese in southern China. We collected medical reports, lifestyle details, and blood samples of individuals and used the polymerase chain reaction-ligase detection reaction method to genotype single-nucleotide polymorphisms (SNPs). Two SNPs showed a strong evidence of association with total cholesterol (TC): rs1003723 and rs6413504 in the low-density lipoproteins receptor (

Indexed as

AgedAsian Peoplebeta-Carotene 15,15'-MonooxygenaseChinaCholesterolDyslipidemiasFemaleGenotypeHumansMaleMiddle AgedPolymorphism, Single NucleotidePotassium Channels, Inwardly RectifyingProprotein Convertase 9Receptors, LDLSolute Carrier Family 12, Member 3BCO1 protein, humanbeta-Carotene 15,15'-MonooxygenaseCholesterolKCNJ1 protein, humanLDLR protein, humanPCSK9 protein, humanPotassium Channels, Inwardly RectifyingProprotein Convertase 9Receptors, LDLSLC12A3 protein, humanSolute Carrier Family 12, Member 3TriglyceridesdyslipidemiaLDLRPCSK9plasma lipid levelsSLC12A3

Identifiers

PMID31480784

DOI10.3390/ijerph16173207

PMCPMC6747169

OpenAlexW2970860881

What Socratic holds

Textfull text, public

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.