Evidence map›Paper›PMID 31481697›Full record

SynthesisJournal of human hypertension2019

Effects of L-carnitine supplementation on blood pressure: a systematic review and meta-analysis of randomized controlled trials.

Moein Askarpour, Amir Hadi, Azadeh Dehghani Kari Bozorg, Omid Sadeghi, Ali Sheikhi, Maryam Kazemi, Ehsan Ghaedi

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of human hypertension, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 4 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 4 syntheses or guidelines pooled it, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Moein AskarpourDepartment of Community Nutrition, School of Nutritional Sciences and Dietetics, International Campus, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Amir HadiHalal Research Center of IRI, FDA, Tehran, Iran.
Azadeh Dehghani Kari BozorgDepartment of Community Nutrition, School of Nutritional Sciences and Dietetics, International Campus, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Omid SadeghiDepartment of Community Nutrition, School of Nutritional Sciences and Dietetics, International Campus, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Ali SheikhiDepartment of Community Nutrition, School of Nutritional Sciences and Dietetics, International Campus, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Maryam KazemiDivision of Nutritional Sciences, Human Metabolic Research Unit, Cornell University, Ithaca, NY, USA.
Ehsan GhaediStudents' Scientific Research Center (SSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran. ehsanghaedi073@gmail.com.ORCID http://orcid.org/0000-0003-4095-1591
Tehran University of Medical Sciences · IRCornell University · USIsfahan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

L-carnitine plays a fundamental biological role in the metabolism of lipids and may positively affect blood pressure by decreasing insulin resistance, although the latter remains less clear. We aimed to assess the effects of L-carnitine supplementation on systolic (SBP) and diastolic blood pressure (DBP). A search was conducted using databases of EMBASE, PubMed, Scopus, Cochrane Library, and ISI web of Science from inception to February 2019 without limitations in language. A meta-analysis was conducted on a total of ten eligible randomized controlled trials using a random-effects model to estimate the pooled effect sizes of L-carnitine supplementation on SBP and DBP levels. Results were expressed as weighted mean difference (WMD) and 95% confidence intervals (CI). L-carnitine supplementation decreased DBP (-1.162 mmHg, 95% CI: -2.020, -0.303, p = 0.008) without changing SBP levels (-0.085 mmHg, 95% CI: -1.455, 1.285, p = 0.903). Results of the subgroup analyses revealed L-carnitine supplementation decreased DBP levels in participants with overweight and obesity (-1.232 mmHg, 95% CI: -2.297, -0.167, p = 0.023) and with doses of <2 g/d (-1.639 mmHg, 95% CI: -3.038, -0.240, p = 0.022). No evidence of publication bias was observed about the effects of L-carnitine supplementation on SBP (p = 0.307) and DBP (p = 0.729), as evidenced by the results of the Egger's test. In conclusion, L-carnitine supplementation decreased DBP without affecting SBP levels. Research is required to determine the molecular mechanism underlying the relationship between of L-carnitine on blood pressure.

Indexed as

Dietary SupplementsAdultAgedAged, 80 and overAntihypertensive AgentsBlood PressureCarnitineFemaleHumansHypertensionMaleMiddle AgedRandomized Controlled Trials as TopicTreatment OutcomeAntihypertensive AgentsCarnitine

Identifiers

PMID31481697
OpenAlexW2971498294

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.