ReviewJournal of neurosurgical anesthesiology2020
Anesthesia and Cognitive Outcome in Elderly Patients: A Narrative Viewpoint.
Review in Journal of neurosurgical anesthesiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cognitive Impairment Following Clinical or Recreational Use of Gammahydroxybutyric Acid (GHB): A Systematic Review.Current neuropharmacology · 2022Pooled it
- Multimodal Brain Monitoring-Guided Anesthesia Management Improves Functional Connectivity, Enhances Recovery and Attenuates Postoperative Pain in Elderly Surgical Patients.Clinical interventions in aging · 2025Trial
- The Impact of Anesthetic Management Under Bispectral Index Monitoring on the Early Recovery Quality of Elderly Patients Undergoing Laparoscopic Surgery: A Blinded Randomized Controlled Trial.Clinical interventions in aging · 2025Trial
- Awake Percutaneous Cervical Cordotomy in Patients With Cancer: A Technical Report.Pain practice : the official journal of World Institute of Pain · 2026Article
- Anesthetic-induced epigenetic alterations: mechanisms and long-term clinical implications.Epigenetics · 2025Review
- Intermittent Fasting Improves Sevoflurane-Induced Cognitive Dysfunction in Rats Through SIRT1-Mediated Autophagy.Neurochemical research · 2025Article
- A 74-Year-Old Man with Severe Comorbidities and Successful Abdominal Aortic Aneurysm Repair with Thoracic Segmental Spinal Anesthesia: A Case Report.The American journal of case reports · 2024Article
- The impact of surgery with general anesthesia on cognitive function and putamen volume: a cross-sectional study among older adults.Frontiers in aging neuroscience · 2024Article
- Article
- Cognitive function in older patients and their stress challenge using different anesthesia regimes: a single center observational study.BMC anesthesiology · 2023Observational
- Third-line therapy for overactive bladder in the elderly: Nuances and considerations.Neurourology and urodynamics · 2022Review
- Metformin alleviates prolonged isoflurane inhalation induced cognitive decline via reducing neuroinflammation in adult mice.International immunopharmacology · 2022Article
- Article
- A Comparison of Operative Time and Intraoperative Blood Volume Loss Between Stemless and Short-stem Anatomic Total Shoulder Arthroplasty: A Single Institution's Experience.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2022Article
- Connexin 43 gap junction-mediated astrocytic network reconstruction attenuates isoflurane-induced cognitive dysfunction in mice.Journal of neuroinflammation · 2022Article
- Editorial: Metabolic Alterations in Neurodegenerative Disorders.Frontiers in aging neuroscience · 2022Article
- A randomized trial: bispectral-guided anesthesia decreases incidence of delayed neurocognitive recovery and postoperative neurocognitive disorder but not postoperative delirium.American journal of translational research · 2022Article
- Gut microbiota: a new player in the pathogenesis of perioperative neurocognitive disorder?Ibrain · 2021Review
- Choosing Neuroanaesthesia as a career: Marching towards new horizons.Indian journal of anaesthesia · 2021Article
- Amelioration of Hippocampal Insulin Resistance Reduces Tau Hyperphosphorylation and Cognitive Decline Induced by Isoflurane in Mice.Frontiers in aging neuroscience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Better ways to manage preoperative, intraoperative and postoperative care of surgical patients is the bailiwick of anesthesiologists. Although we care for patients of all ages, protecting the cognitive capacity of elderly patients more frequently requires procedures and practices that go beyond routine care for nonelderly adults. This narrative review will consider current understanding of the reasons that elderly patients need enhanced care, and recommendations for that care based on established and recent empirical research. In that latter regard, unless and until we are able to classify anesthetic neurotoxicity as a rare complication, the first-do-no-harm approach should: (1) add anesthesia to surgical intervention on the physiological cost side of the cost/benefit ratio when making decisions about whether and when to proceed with surgery; (2) minimize anesthetic depth and periods of electroencephalographic suppression; (3) limit the duration of continuous anesthesia whenever possible; (4) consider the possibility that regional anesthesia with deep sedation may be as neurotoxic as general anesthesia; and (5) when feasible, use regional anesthesia with light or no sedation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.