Evidence map›Paper›PMID 31493487›Full record

ReviewProgress in retinal and eye research2020

Membrane-associated mucins of the ocular surface: New genes, new protein functions and new biological roles in human and mouse.

M Elizabeth Fini, Shinwu Jeong, Haiyan Gong, Rafael Martinez-Carrasco, Nora M V Laver, Minako Hijikata, Naoto Keicho, Pablo Argüeso

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Progress in retinal and eye research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
  2. Review
  3. Ocular surface glycocalyx in health and disease.Frontiers in cell and developmental biology · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Animal Models in Eye Research: Focus on Corneal Pathologies.International journal of molecular sciences · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Immunocytochemical characterization ofFrontiers in medicine · 2023
    Article
  13. Review
  14. Article
  15. Review
  16. Human ocular mucins: The endowed guardians of sight.Advanced drug delivery reviews · 2022
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

M Elizabeth FiniDepartment of Ophthalmology, Tufts University School of Medicine, at New England Eye Center, Tufts Medical Center, 800 Washington St, Boston, MA, 02111, USA. Electronic address: mefini@tuftsmedicalcenter.org.
Shinwu JeongUSC Roski Eye Institute and Department of Ophthalmology, Keck School of Medicine of USC, University of Southern California, 1975 Zonal Ave, Los Angeles, CA, 90033, USA. Electronic address: shinwuje@med.usc.edu.
Haiyan GongDepartment of Ophthalmology, Boston University School of Medicine, 72 E Concord St, Boston, MA, 02118, USA. Electronic address: haiyan2k@yahoo.com.
Rafael Martinez-CarrascoDepartment of Ophthalmology, Tufts University School of Medicine, at New England Eye Center, Tufts Medical Center, 800 Washington St, Boston, MA, 02111, USA. Electronic address: rmartinezcarras@tuftsmedicalcenter.org.
Nora M V LaverDepartment of Ophthalmology, Tufts University School of Medicine, at New England Eye Center, Tufts Medical Center, 800 Washington St, Boston, MA, 02111, USA. Electronic address: nlaver@tuftsmedicalcenter.org.
Minako HijikataDepartment of Pathophysiology and Host Defense, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, 3-1-24 Matsuyama, Kiyose-shi, Tokyo, 204-8533, Japan. Electronic address: mhijikata@jata.or.jp.
Naoto KeichoDepartment of Pathophysiology and Host Defense, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, 3-1-24 Matsuyama, Kiyose-shi, Tokyo, 204-8533, Japan. Electronic address: nkeicho@jata.or.jp.
Pablo ArgüesoDepartment of Ophthalmology, Harvard Medical School, at Schepens Eye Research Institute of Mass. Eye and Ear, 20 Staniford St, Boston, MA, 02114, USA. Electronic address: Pablo_Argueso@MEEI.HARVARD.EDU.

Funding

Clusterin at the Ocular Surface Administrative Supplement IIR01EY026479 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FINI, M ELIZABETH · 2016 to 2020
$2.9M
Discovery Approach to Ocular HypertensionR01EY027315 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FINI, M ELIZABETH, GAO, XIAOYI RAYMOND · 2017 to 2020
$2.4M
NEI NIH HHS R01 EY026479NEI NIH HHS R01 EY027315
6 · The paper itself

Abstract

The mucosal glycocalyx of the ocular surface constitutes the point of interaction between the tear film and the apical epithelial cells. Membrane-associated mucins (MAMs) are the defining molecules of the glycocalyx in all mucosal epithelia. Long recognized for their biophysical properties of hydration, lubrication, anti-adhesion and repulsion, MAMs maintain the wet ocular surface, lubricate the blink, stabilize the tear film and create a physical barrier to the outside world. However, it is increasingly appreciated that MAMs also function as cell surface receptors that transduce information from the outside to the inside of the cell. A number of excellent review articles have provided perspective on the field as it has progressed since 1987, when molecular cloning of the first MAM was reported. The current article provides an update for the ocular surface, placing it into the broad context of findings made in other organ systems, and including new genes, new protein functions and new biological roles. We discuss the epithelial tissue-equivalent with mucosal differentiation, the key model system making these advances possible. In addition, we make the first systematic comparison of MAMs in human and mouse, establishing the basis for using knockout mice for investigations with the complexity of an in vivo system. Lastly, we discuss findings from human genetics/genomics, which are providing clues to new MAM roles previously unimagined. Taken together, this information allows us to generate hypotheses for the next stage of investigation to expand our knowledge of MAM function in intracellular signaling and roles unique to the ocular surface.

Indexed as

AnimalsConjunctivaEpithelial CellsHumansMembrane ProteinsMiceMucinsTearsMembrane ProteinsMucinsEpithelial tissue-equivalentGlycocalyxKnockout mouseMembrane-associated mucinOcular surfaceSignal transduction

Identifiers

PMID31493487
PMCPMC10276350

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.