Evidence mapPaperPMID 31497187Full record

ReviewAmerican journal of translational research2019

Modelling of atherosclerosis in genetically modified animals.

Natalia V Mushenkova, Volha I Summerhill, Yulia Yu Silaeva, Alexey V Deykin, Alexander N Orekhov

Open access · greenAbstract readReview
In one paragraph

Review in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Tackling Atherosclerosis via Selected Nutrition.International journal of molecular sciences · 2022
    Review
  6. Article
  7. Review
  8. Stiffness of aortic arch and carotid arteries increases inAmerican journal of translational research · 2021
    Article
  9. Recent Application of Zebrafish Models in Atherosclerosis Research.Frontiers in cell and developmental biology · 2021
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Natalia V MushenkovaPharmstandard Ventures 10 Testovskaya Street, Moscow 123112, Russia.
Volha I SummerhillInstitute for Atherosclerosis Research, Skolkovo Innovative Centre Moscow 121609, Russia.
Yulia Yu SilaevaCentre of Collective Usage, Institute of Gene Biology, Russian Academy of Sciences 34/5 Vavilova Street, Moscow 119334, Russia.
Alexey V DeykinCentre of Collective Usage, Institute of Gene Biology, Russian Academy of Sciences 34/5 Vavilova Street, Moscow 119334, Russia.
Alexander N OrekhovInstitute for Atherosclerosis Research, Skolkovo Innovative Centre Moscow 121609, Russia.
Institute of Gene Biology · RUInstitute for Atherosclerosis Research · RURussian Venture Company · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerosis is a lipid-driven, chronic inflammatory disease that leads to plaque formation at specific sites of the arterial tree. Being the common cause of many cardiovascular disorders, atherosclerosis makes a tremendous impact on morbidity and mortality rates of cardiovascular diseases (CVDs) in countries with higher income. Animal models of atherosclerosis are utilized as useful tools for studying the aetiology, pathogenesis and complications of atherosclerosis, thus, providing a valuable platform for the efficacy testing of different pharmacological therapies and validation of imaging techniques. To date, a large variety of models is available. Pathophysiological changes can be induced in animals by either an atherogenic diet or genetic manipulations. The discussion of advantages and disadvantages of some murine, rabbit and porcine genetic models currently available for the atherosclerosis research is the scope of the following review.

Indexed as

Atherosclerosisgenetic animal models of human atherosclerosismurine models of human atherosclerosisporcine models of human atherosclerosisrabbit models of human atherosclerosis

Identifiers

PMID31497187
PMCPMC6731422
OpenAlexW2995531801

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.