ReviewFrontiers of hormone research2019
In utero Androgen Excess: A Developmental Commonality Preceding Polycystic Ovary Syndrome?
Review in Frontiers of hormone research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 38 citations in OpenAlex.
- Sustained Maternal Hyperandrogenism During PCOS Pregnancy Reduced by Metformin in Non-obese Women Carrying a Male Fetus.The Journal of clinical endocrinology and metabolism · 2020Trial
- Hypoadiponectinemia does not enhance anxiety-like behaviour in a lean PCOS-like mouse model.Scientific reports · 2026Article
- Molecular Mechanisms Underlying Reproductive Dysfunction in Polycystic Ovary Syndrome.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- Amniotic-fluid metabolomics identifies phospholipid remodeling as a metabolic signature of intrauterine exposure in pregnancies with polycystic ovary syndrome.Frontiers in endocrinology · 2026Article
- Ovarian-Specific Cyp17A1 Overexpression in Female Mice: A Novel Model of Endogenous Testosterone Excess.Endocrinology · 2025Article
- Closer look at circulating nitric oxide levels and their association with polycystic ovary syndrome: A meta-analytical exploration.International journal of reproductive biomedicine · 2024Article
- Female-specific risk factors for cardiovascular disease: an update.Hormones (Athens, Greece) · 2024Review
- Distinct Reproductive Phenotypes Segregate With Differences in Body Weight in Adolescent Polycystic Ovary Syndrome.Journal of the Endocrine Society · 2024Article
- A review of nitric oxide and oxidative stress in typical ovulatory women and in the pathogenesis of ovulatory dysfunction in PCOS.Reproductive biology and endocrinology : RB&E · 2023Review
- Assessment of Type 2 Diabetes Risk in Young Women with Polycystic Ovary Syndrome.Diagnostics (Basel, Switzerland) · 2023Review
- Androgen signalling in the ovaries and endometrium.Molecular human reproduction · 2023Review
- Maternal Polycystic Ovary Syndrome and the Risk of Early Childhood Obesity in Female Offspring: A Nationwide Population-Based Study.Journal of Korean medical science · 2023Article
- Effects of Mindfulness-Based Therapy on Clinical Symptoms and DNA Methylation in Patients with Polycystic Ovary Syndrome and High Metabolic Risk.Current issues in molecular biology · 2023Article
- Comparison of Placental HSD17B1 Expression and Its Regulation in Various Mammalian Species.Animals : an open access journal from MDPI · 2023Article
- Integrated bioinformatics analysis and screening of hub genes in polycystic ovary syndrome.Endocrine · 2022Article
- Update on Animal Models of Polycystic Ovary Syndrome.Endocrinology · 2022Article
- The Role of Genetics, Epigenetics and Lifestyle in Polycystic Ovary Syndrome Development: the State of the Art.Reproductive sciences (Thousand Oaks, Calif.) · 2022Review
- Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment.International journal of environmental research and public health · 2022Review
- Developmental programming of offspring adipose tissue biology and obesity risk.International journal of obesity (2005) · 2021Review
- Variation among human populations in endometriosis and PCOS A test of the inverse comorbidity model.Evolution, medicine, and public health · 2021Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
In utero androgen excess reliably induces polycystic ovary syndrome (PCOS)-like reproductive and metabolic traits in female monkeys, sheep, rats, and mice. In humans, however, substantial technical and ethical constraints on fetal sampling have curtailed safe, pathogenic exploration during gestation. Evidence consistent with in utero origins for PCOS in humans has thus been slow to amass, but the balance now leans toward developmental fetal origins. Given that PCOS is familial and highly heritable, difficulties encountered in discerning genetic contributions to PCOS pathogenesis are puzzling and, to date, accounts for <10% of PCOS presentations. Unaccounted heritability notwithstanding, molecular commonality in pathogenic mechanisms is emerging, suggested by co-occurrence at the same gene loci of (1) PCOS genetic variants (PCOS women), (2) epigenetic alterations in DNA methylation (PCOS women), and (3) bioinformatics, gene networks-identified, epigenetic alterations in DNA methylation (female rhesus monkeys exposed to testosterone (T) in utero). In addition, naturally occurring hyperandrogenism in female monkeys singles out individuals with PCOS-like reproductive and metabolic traits accompanied by somatic biomarkers of in utero T exposure. Such phenotypic and molecular convergence between highly related species suggests not only dual genetic and epigenetic contributions to a developmental origin of PCOS but also common molecular pathogenesis extending beyond humans.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.