ArticleThe American journal of clinical nutrition2019
Abdominal adiposity and cardiometabolic risk factors in children and adolescents: a Mendelian randomization analysis.
Article in The American journal of clinical nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Polygenic scores and physical fitness prediction: a systematic review.Human genetics · 2026Pooled it
- Is dancing an effective intervention for fat loss? A systematic review and meta-analysis of dance interventions on body composition.PloS one · 2024Pooled it
- Effect of High-Intensity Interval Training vs. Moderate-Intensity Continuous Training on Fat Loss and Cardiorespiratory Fitness in the Young and Middle-Aged a Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2023Pooled it
- Central obesity and its association with youth physical and mental health: evidence from the Australian National Health Survey.BMC medicine · 2025Article
- Cardiometabolic Outcomes Among Adults With Abdominal Obesity and Normal Body Mass Index.JAMA network open · 2025Article
- Obesity and Overweight-Practical Management for Indian Setting.Indian journal of pediatrics · 2025Review
- Longitudinal changes in preschoolers' adiposity indicators according to compliance with 24-hour movement behavior guidelines: results from the ToyBox-study.BMC public health · 2024Article
- Article
- Screen time, sleep duration, leisure physical activity, obesity, and cardiometabolic risk in children and adolescents: a cross-lagged 2-year study.BMC cardiovascular disorders · 2024Observational
- Genetic associations of birthweight, childhood, and adult BMI with metabolic dysfunction-associated steatotic liver disease: a Mendelian randomization.BMC gastroenterology · 2024Article
- Lifestyle Clusters of Diet Quality, Sleep, and Screen Time and Associations with Weight Status in Children from Madrid City: ENPIMAD Study.Nutrients · 2024Article
- Body mass index mediates the association between plasma lipid concentrations and the prevalence of obstructive sleep apnea among US adults: a cross-sectional study.Frontiers in cardiovascular medicine · 2024Article
- BMI-based obesity classification misses children and adolescents with raised cardiometabolic risk due to increased adiposity.Cardiovascular diabetology · 2023Article
- Differential DNA Methylation and Cardiometabolic Risk in African American Mother-Adolescent Dyads.Biological research for nursing · 2022Article
- Evaluating the direct effects of childhood adiposity on adult systemic metabolism: a multivariable Mendelian randomization analysis.International journal of epidemiology · 2021Article
- GWAS in Africans identifies novel lipids loci and demonstrates heterogenous association within Africa.Human molecular genetics · 2021Article
- Phenome-wide investigation of the causal associations between childhood BMI and adult trait outcomes: a two-sample Mendelian randomization study.Genome medicine · 2021Article
- Genetics of early growth traits.Human molecular genetics · 2020Review
- Chinese men living in urban areas of Shijiazhuang, Hebei at higher risk of overweight or obesity.The Journal of international medical research · 2020Article
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Authors and funding
23 authors.
Funding
Abstract
backgroundMendelian randomization studies in adults suggest that abdominal adiposity is causally associated with increased risk of type 2 diabetes and coronary artery disease in adults, but its causal effect on cardiometabolic risk in children remains unclear.
objectiveWe aimed to study the causal relation of abdominal adiposity with cardiometabolic risk factors in children by applying Mendelian randomization.
methodsWe constructed a genetic risk score (GRS) using variants previously associated with waist-to-hip ratio adjusted for BMI (WHRadjBMI) and examined its associations with cardiometabolic factors by linear regression and Mendelian randomization in a meta-analysis of 6 cohorts, including 9895 European children and adolescents aged 3-17 y.
resultsWHRadjBMI GRS was associated with higher WHRadjBMI (β = 0.021 SD/allele; 95% CI: 0.016, 0.026 SD/allele; P = 3 × 10-15) and with unfavorable concentrations of blood lipids (higher LDL cholesterol: β = 0.006 SD/allele; 95% CI: 0.001, 0.011 SD/allele; P = 0.025; lower HDL cholesterol: β = -0.007 SD/allele; 95% CI: -0.012, -0.002 SD/allele; P = 0.009; higher triglycerides: β = 0.007 SD/allele; 95% CI: 0.002, 0.012 SD/allele; P = 0.006). No differences were detected between prepubertal and pubertal/postpubertal children. The WHRadjBMI GRS had a stronger association with fasting insulin in children and adolescents with overweight/obesity (β = 0.016 SD/allele; 95% CI: 0.001, 0.032 SD/allele; P = 0.037) than in those with normal weight (β = -0.002 SD/allele; 95% CI: -0.010, 0.006 SD/allele; P = 0.605) (P for difference = 0.034). In a 2-stage least-squares regression analysis, each genetically instrumented 1-SD increase in WHRadjBMI increased circulating triglycerides by 0.17 mmol/L (0.35 SD, P = 0.040), suggesting that the relation between abdominal adiposity and circulating triglycerides may be causal.
conclusionsAbdominal adiposity may have a causal, unfavorable effect on plasma triglycerides and potentially other cardiometabolic risk factors starting in childhood. The results highlight the importance of early weight management through healthy dietary habits and physically active lifestyle among children with a tendency for abdominal adiposity.
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