Evidence map›Paper›PMID 31511532›Full record

ArticleNature communications2019

Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria.

Alexander Teumer, Yong Li, Sahar Ghasemi, Bram P Prins, Matthias Wuttke, Tobias Hermle, Ayush Giri, Karsten B Sieber, Chengxiang Qiu, Holger Kirsten and 176 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 154 papers, 21 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
154citing papers in PubMed, 21 pooled it
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

154 citing papers in PubMed, 21 syntheses or guidelines pooled it, 233 citations in OpenAlex.

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  18. Guideline
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94 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

186 authors at 20 institutions in 14 countries.

Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. ateumer@uni-greifswald.de.ORCID http://orcid.org/0000-0002-8309-094X
Yong LiInstitute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0003-2651-8791
Sahar GhasemiInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Bram P PrinsMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Matthias WuttkeInstitute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0003-3420-5082
Tobias HermleRenal Division, Department of Medicine, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.
Ayush GiriDivision of Quantitative Sciences, Department of Obstetrics & Gynecology, Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-7786-4670
Karsten B SieberTarget Sciences - Genetics, GlaxoSmithKline, Collegeville, PA, USA.
Chengxiang QiuRenal Electrolyte and Hypertension Division, Department of Medicine, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA.ORCID http://orcid.org/0000-0002-6346-8669
Holger KirstenInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0002-3126-7950
Adrienne TinDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-4207-5866
Audrey Y ChuGenetics, Merck & Co., Inc., Kenilworth, NJ, USA.
Nisha BansalDivision of Nephrology, University of Washington, Seattle, WA, USA.
Mary F FeitosaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-0933-2410
Lihua WangDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Jin-Fang ChaiSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.ORCID http://orcid.org/0000-0003-3770-1137
Massimiliano CoccaInstitute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.ORCID http://orcid.org/0000-0002-1127-7596
Christian FuchsbergerEurac Research, Institute for Biomedicine (affiliated to the University of Lübeck), Bolzano, Italy.
Mathias GorskiDepartment of Nephrology, University Hospital Regensburg, Regensburg, Germany.ORCID http://orcid.org/0000-0002-9103-5860
Anselm HoppmannInstitute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.
Katrin HornInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0002-5307-6936
Man LiDepartment of Medicine, Division of Nephrology and Hypertension, University of Utah, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0002-3839-0281
Jonathan MartenMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-6916-2014
Damia NoceEurac Research, Institute for Biomedicine (affiliated to the University of Lübeck), Bolzano, Italy.
Teresa NutileInstitute of Genetics and Biophysics "Adriano Buzzati-Traverso" - CNR, Naples, Italy.
Sanaz SedaghatDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Gardar SveinbjornssondeCODE Genetics, Amgen Inc., Reykjavik, Iceland.
Bamidele O TayoDepartment of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA.
Peter J van der MostDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0001-8450-3518
Yizhe XuDepartment of Medicine, Division of Nephrology and Hypertension, University of Utah, Salt Lake City, UT, USA.
Zhi YuDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Lea GerstnerRenal Division, Department of Medicine, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.
Johan ÄrnlövDepartment of Neurobiology, Care Sciences and Society, Division of Family Medicine and Primary Care, Karolinska Institutet, Stockholm, Sweden.
Stephan J L BakkerDepartment of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Daniela BaptistaCardiology, Geneva University Hospitals, Geneva, Switzerland.
Mary L BiggsCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Eric BoerwinkleHuman Genetics Centre, University of Texas Health Science Centre, Houston, TX, USA.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Heidelberg, Germany.
Ralph BurkhardtLIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0003-1924-1202
Robert J CarrollDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Miao-Li CheeSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Miao-Ling CheeSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Mengmeng ChenRenal Division, Department of Medicine, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.
Ching-Yu ChengSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
James P CookDepartment of Biostatistics, University of Liverpool, Liverpool, UK.
Josef CoreshDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-4598-0669
Tanguy CorreCenter for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.
John DaneshDepartment of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Martin H de BorstDepartment of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0002-4127-8733
Alessandro De GrandiEurac Research, Institute for Biomedicine (affiliated to the University of Lübeck), Bolzano, Italy.
Renée de MutsertDepartment of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands.
Aiko P J de VriesSection of Nephrology, Department of Internal Medicine, Leiden University Medical Centre, Leiden, The Netherlands.
Frauke DegenhardtInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
Katalin DittrichDepartment of Women and Child Health, Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany.
Jasmin DiversDepartment of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Kai-Uwe EckardtIntensive Care Medicine, Charité, Berlin, Germany.
Georg EhretCardiology, Geneva University Hospitals, Geneva, Switzerland.ORCID http://orcid.org/0000-0002-5730-0675
Karlhans EndlichDZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0001-6052-6061
Janine F FelixDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-9801-5774
Oscar H FrancoDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Andre FrankeInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.ORCID http://orcid.org/0000-0003-1530-5811
Barry I FreedmanInternal Medicine - Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA.ORCID http://orcid.org/0000-0003-0275-5530
Sandra Freitag-WolfInstitute of Medical Informatics and Statistics, Kiel University, University Hospital Schleswig-Holstein, Kiel, USA.ORCID http://orcid.org/0000-0002-1069-7740
Ron T GansevoortDepartment of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Vilmantas GiedraitisDepartment of Public Health and Caring Sciences, Molecular Geriatrics, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0003-3423-2021
Martin GögeleEurac Research, Institute for Biomedicine (affiliated to the University of Lübeck), Bolzano, Italy.
Franziska Grundner-CulemannInstitute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0001-9649-281X
Daniel F GudbjartssondeCODE Genetics, Amgen Inc., Reykjavik, Iceland.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.ORCID http://orcid.org/0000-0001-5696-0084
Pavel HametMontreal University Hospital Research Centre, CHUM, Montreal, QC, Canada.
Tamara B HarrisLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.
Andrew A HicksEurac Research, Institute for Biomedicine (affiliated to the University of Lübeck), Bolzano, Italy.ORCID http://orcid.org/0000-0001-6320-0411
Hilma HolmdeCODE Genetics, Amgen Inc., Reykjavik, Iceland.
Valencia Hui Xian FooSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Shih-Jen HwangNHLBI's Framingham Heart Study, Framingham, MA, USA.
M Arfan IkramDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-0372-8585
Erik IngelssonDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-2256-6972
Vincent W V JaddoeDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-2939-0041
Johanna JakobsdottirIcelandic Heart Association, Holtasmari 1, Kopavogur, IS-201, Iceland.
Navya Shilpa JosyulaGeisinger Research, Biomedical and Translational Informatics Institute, Rockville, MD, USA.ORCID http://orcid.org/0000-0003-2782-8812
Bettina JungDepartment of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, Tampere, Finland.
Chiea-Chuen KhorSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.ORCID http://orcid.org/0000-0002-1128-4729
Wieland KiessLIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Wolfgang KoenigDeutsches Herzzentrum München, Technische Universität München, Munich, Germany.ORCID http://orcid.org/0000-0002-2064-9603
Antje KörnerLIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Peter KovacsIntegrated Research and Treatment Centre Adiposity Diseases, University of Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0002-0290-5423
Holly KramerDepartment of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA.
Bernhard K Krämer5th Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Florian KronenbergDivision of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.ORCID http://orcid.org/0000-0003-2229-1120
Leslie A LangeDivision of Biomedical Informatics and Personalized Medicine, School of Medicine, University of Colorado Denver - Anschutz Medical Campus, Aurora, CO, USA.
Carl D LangefeldDepartment of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Jeannette Jen-Mai LeeSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Wolfgang LiebInstitute of Epidemiology and Biobank Popgen, Kiel University, Kiel, Germany.
Su-Chi LimSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Lars LindCardiovascular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Cecilia M LindgrenNuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-4903-9374
Jianjun LiuGenome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore.ORCID http://orcid.org/0000-0002-3255-3019
Markus LoefflerInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.ORCID http://orcid.org/0000-0002-7200-5455
Anubha MahajanWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-5585-3420
Joseph C MaranvilleMRL, Merck & Co., Inc., Kenilworth, NJ, USA.
Deborah MascalzoniEurac Research, Institute for Biomedicine (affiliated to the University of Lübeck), Bolzano, Italy.ORCID http://orcid.org/0000-0003-4156-1464
Barbara McMullenVanderbilt University School of Medicine, Nashville, TN, USA.
Christa MeisingerIndependent Research Group Clinical Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany.
Thomas MeitingerDZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
Kozeta MilikuDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-9614-7191
Dennis O Mook-KanamoriDepartment of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands.
Martina Müller-NurasyidInstitute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg, Germany.ORCID http://orcid.org/0000-0003-3793-5910
Josyf C MychaleckyjCentre for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0003-2595-0005
Matthias NauckDZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.
Kjell NikusDepartment of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland.
Boting NingDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Raymond NoordamSection of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Centre, Leiden, The Netherlands.
Jeffrey O' ConnellUniversity of Maryland School of Medicine, Baltimore, MD, USA.
Isleifur OlafssonDepartment of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland.
Nicholette D PalmerBiochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.ORCID http://orcid.org/0000-0001-8883-2511
Annette PetersDZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
Anna I PodgornaiaGenetics, Merck & Co., Inc., Kenilworth, NJ, USA.
Belen PonteService de Néphrologie, Geneva University Hospitals, Geneva, Switzerland.
Tanja PoulainLIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0003-3825-5829
Peter P PramstallerEurac Research, Institute for Biomedicine (affiliated to the University of Lübeck), Bolzano, Italy.
Ton J RabelinkSection of Nephrology, Department of Internal Medicine, Leiden University Medical Centre, Leiden, The Netherlands.
Laura M RaffieldDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-7892-193X
Dermot F ReillyGenetics, Merck & Co., Inc., Kenilworth, NJ, USA.
Rainer RettigInstitute of Physiology, University Medicine Greifswald, Karlsburg, Germany.
Myriam RheinbergerDepartment of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Kenneth M RiceDepartment of Biostatistics, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3071-7278
Fernando RivadeneiraDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0001-9435-9441
Heiko RunzMRL, Merck & Co., Inc., Kenilworth, NJ, USA.
Kathleen A RyanDivision of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.
Charumathi SabanayagamSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.ORCID http://orcid.org/0000-0002-4042-4719
Kai-Uwe SaumDivision of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Heidelberg, Germany.
Ben SchöttkerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Heidelberg, Germany.
Christian M ShafferDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Yuan ShiSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Albert V SmithFaculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.ORCID http://orcid.org/0000-0003-1942-5845
Konstantin StrauchInstitute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg, Germany.
Michael StumvollDepartment of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.
Benjamin B SunMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-6347-2281
Silke SzymczakInstitute of Medical Informatics and Statistics, Kiel University, University Hospital Schleswig-Holstein, Kiel, USA.ORCID http://orcid.org/0000-0002-8897-9035
E-Shyong TaiSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Nicholas Y Q TanSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Kent D TaylorThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID http://orcid.org/0000-0002-2756-4370
Andrej TerenLIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Yih-Chung ThamSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Joachim ThieryLIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Chris H L ThioDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0003-2623-7172
Hauke ThomsenDivision of Molecular Genetic Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany.
Unnur ThorsteinsdottirdeCODE Genetics, Amgen Inc., Reykjavik, Iceland.
Anke TönjesDepartment of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.
Johanne TremblayMontreal University Hospital Research Centre, CHUM, Montreal, QC, Canada.
André G UitterlindenDepartment of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-7276-3387
Pim van der HarstDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0002-2713-686X
Niek VerweijDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0002-4303-7685
Suzanne VogelezangDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Uwe VölkerDZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-5689-3448
Melanie WaldenbergerDZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
Chaolong WangGenome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore.ORCID http://orcid.org/0000-0003-3945-1012
Otis D WilsonVanderbilt University Medical Centre, Division of Nephrology & Hypertension, Nashville, TN, USA.
Charlene WongDepartment of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.
Tien-Yin WongSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Qiong YangDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3658-1375
Masayuki YasudaSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Shreeram AkileshKidney Research Institute, University of Washington, Seattle, WA, USA.
Murielle BochudCenter for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.
Carsten A BögerDepartment of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Olivier DevuystInstitute of Physiology, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0003-3744-4767
Todd L EdwardsDivision of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Centre, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-4318-6119
Kevin HoKidney Health Research Institute (KHRI), Geisinger, Danville, PA, USA.ORCID http://orcid.org/0000-0002-3054-8697
Andrew P MorrisDepartment of Biostatistics, University of Liverpool, Liverpool, UK.ORCID http://orcid.org/0000-0002-6805-6014
Afshin ParsaDivision of Kidney, Urologic and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Sarah A PendergrassGeisinger Research, Biomedical and Translational Informatics Institute, Danville, PA, USA.ORCID http://orcid.org/0000-0002-0565-6522
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, Department of Epidemiology, Department of Health Service, University of Washington, Seattle, WA, USA.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID http://orcid.org/0000-0001-7191-1723
Kari StefanssondeCODE Genetics, Amgen Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0003-1676-864X
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Centre, Jackson, MS, USA.
Katalin SusztakRenal Electrolyte and Hypertension Division, Department of Medicine, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA.ORCID http://orcid.org/0000-0002-1005-3726
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Iris M HeidDepartment of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Markus ScholzInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0002-4059-1779
Adam S ButterworthMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-6915-9015
Adriana M HungVanderbilt University Medical Centre, Division of Nephrology & Hypertension, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-3203-1608
Cristian PattaroEurac Research, Institute for Biomedicine (affiliated to the University of Lübeck), Bolzano, Italy. cristian.pattaro@eurac.edu.ORCID http://orcid.org/0000-0002-4119-0109
Anna KöttgenInstitute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany. anna.koettgen@uniklinik-freiburg.de.ORCID http://orcid.org/0000-0002-4671-3714
Erasmus MC · NLEurac Research · ITUniversity Medical Center Groningen · NLLeipzig University · DENational University of Singapore · SGSingapore National Eye Center · SGUniversity of Freiburg · DEUniversitätsmedizin Greifswald · DEdeCODE Genetics (Iceland) · ISHelmholtz Zentrum München · DEMerck & Co., Inc., Rahway, NJ, USA (United States) · USUniversity Hospital Regensburg · DEGerman Cancer Research Center · DEJohns Hopkins University · USLeiden University · NLTampere University · FIUniversity of Cambridge · GBUniversity of Washington · USVanderbilt University · USWake Forest University · US

Funding

Stanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI FREDRIC B. KRAEMER · 2017 to 2026
$19.5M
Building Interdisciplinary Research Careers in Women's HealthK12HD043483 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARTMANN, KATHERINE E, MAJOR, AMY S · 2002 to 2023
$10.3M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
CHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6M
Rare variants and NHLBI traits in deeply phenotyped cohortsU01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2017 to 2018
$5.6M
The Genetic Epidemiology of Heart, Lung, and Blood TraitsTraining Grant (GenHLB)T32HL129982 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Christy Leigh Avery, KAREN L. MOHLKE · 2016 to 2026
$3.8M
BLRD VA I01 BX003360CSRD VA I01 CX001897Medical Research Council MC_PC_17228Medical Research Council MC_QA137853NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS T32 HL129982NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U01 HL130114NICHD NIH HHS K12 HD043483NIDDK NIH HHS P30 DK116074
6 · The paper itself

Abstract

Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we conduct trans-ethnic (n = 564,257) and European-ancestry specific meta-analyses of genome-wide association studies of UACR, including ancestry- and diabetes-specific analyses, and identify 68 UACR-associated loci. Genetic correlation analyses and risk score associations in an independent electronic medical records database (n = 192,868) reveal connections with proteinuria, hyperlipidemia, gout, and hypertension. Fine-mapping and trans-Omics analyses with gene expression in 47 tissues and plasma protein levels implicate genes potentially operating through differential expression in kidney (including TGFB1, MUC1, PRKCI, and OAF), and allow coupling of UACR associations to altered plasma OAF concentrations. Knockdown of OAF and PRKCI orthologs in Drosophila nephrocytes reduces albumin endocytosis. Silencing fly PRKCI further impairs slit diaphragm formation. These results generate a priority list of genes and pathways for translational research to reduce albuminuria.

Indexed as

Chromosome MappingGenome-Wide Association StudyMeta-Analysis as TopicAlbuminuriaAnimalsCreatinineDiabetes MellitusDrosophila melanogasterGene Expression RegulationGenetic LociGenetic Predisposition to DiseaseHumansPhenomicsRisk FactorsCreatinine

Identifiers

PMID31511532
PMCPMC6739370
OpenAlexW2956245605

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.