Evidence map›Paper›PMID 31519463›Full record

ReviewTrends in ecology & evolution2020

The Evolution of Variance Control.

Marjolein Bruijning, C Jessica E Metcalf, Eelke Jongejans, Julien F Ayroles

Abstract readReview
In one paragraph

Review in Trends in ecology & evolution, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Article
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  6. Article
  7. Ecology and evolution · 2024
    Article
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  9. Review
  10. Article
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  13. Review
  14. Review
  15. Article
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  17. Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Marjolein BruijningDepartment of Animal Ecology and Physiology, Radboud University, 6500, GL, Nijmegen, The Netherlands; Department of Ecology and Evolutionary Biology, Princeton University, 08540 Princeton, NJ, USA.
C Jessica E MetcalfDepartment of Ecology and Evolutionary Biology, Princeton University, 08540 Princeton, NJ, USA.
Eelke JongejansDepartment of Animal Ecology and Physiology, Radboud University, 6500, GL, Nijmegen, The Netherlands.
Julien F AyrolesDepartment of Ecology and Evolutionary Biology, Princeton University, 08540 Princeton, NJ, USA. Electronic address: jayroles@princeton.edu.

Funding

A path to personalized phenotypic prediction: unlocking the context-dependency of allelic effectsR35GM124881 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Julien Ayroles · 2017 to 2026
$3.7M
Improved methods for inference of genotype-specific response to environmental toxinsR01ES029929 · NIEHS · PRINCETON UNIVERSITY · PI AYROLES, JULIEN, CLARK, ANDREW G · 2019 to 2023
$3.6M
NIEHS NIH HHS R01 ES029929NIGMS NIH HHS R35 GM124881
6 · The paper itself

Abstract

Genetically identical individuals can be phenotypically variable, even in constant environmental conditions. The ubiquity of this phenomenon, known as 'intra-genotypic variability', is increasingly evident and the relevant mechanistic underpinnings are beginning to be understood. In parallel, theory has delineated a number of formal expectations for contexts in which such a feature would be adaptive. Here, we review empirical evidence across biological systems and theoretical expectations, including nonlinear averaging and bet hedging. We synthesize existing results to illustrate the dependence of selection outcomes both on trait characteristics, features of environmental variability, and species' demographic context. We conclude by discussing ways to bridge the gap between empirical evidence of intra-genotypic variability, studies demonstrating its genetic component, and evidence that it is adaptive.

Indexed as

Biological EvolutionSelection, GeneticGenotypeHumansPhenotypebet hedgingintra-genotypic variabilitymicro-environmental plasticitynonlinear averagingphenotypic variancevQTL

Identifiers

PMID31519463
PMCPMC7482585

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.