Evidence map›Paper›PMID 31523780›Full record

Trial reportEuropean journal of nutrition2020

Effect of changes in adherence to Mediterranean diet on nutrient density after 1-year of follow-up: results from the PREDIMED-Plus Study.

Naomi Cano-Ibáñez, Aurora Bueno-Cavanillas, Miguel Ángel Martínez-González, Jordi Salas-Salvadó, Dolores Corella, Gal-la Freixer, Dora Romaguera, Jesús Vioque, Ángel M Alonso-Gómez, Julia Wärnberg and 42 more

Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

52 authors at 17 institutions in 2 countries.

Naomi Cano-IbáñezDepartment of Preventive Medicine and Public Health, University of Granada, Avda. De la Investigación 11, 18016, Granada, Spain. ncaiba@ugr.es.ORCID http://orcid.org/0000-0002-3640-5486
Aurora Bueno-CavanillasDepartment of Preventive Medicine and Public Health, University of Granada, Avda. De la Investigación 11, 18016, Granada, Spain.ORCID http://orcid.org/0000-0002-0649-3016
Miguel Ángel Martínez-GonzálezDepartment of Preventive Medicine and Public Health, Medical School, University of Navarra, Pamplona, Spain.ORCID http://orcid.org/0000-0002-3917-9808
Jordi Salas-SalvadóCIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Institute of Health, Madrid, Spain.ORCID http://orcid.org/0000-0003-2700-7459
Dolores CorellaCIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Institute of Health, Madrid, Spain.ORCID http://orcid.org/0000-0002-2366-4104
Gal-la FreixerUnit of Cardiovascular Risk and Nutrition, Hospital del Mar, Institut Municipal d'Investigació Médica (IMIM), Barcelona, Spain.
Dora RomagueraCIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Institute of Health, Madrid, Spain.ORCID http://orcid.org/0000-0002-5762-8558
Jesús VioqueCIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.ORCID http://orcid.org/0000-0002-2284-148X
Ángel M Alonso-GómezCIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Institute of Health, Madrid, Spain.ORCID http://orcid.org/0000-0003-2945-7509
Julia WärnbergCIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Institute of Health, Madrid, Spain.ORCID http://orcid.org/0000-0002-8408-316X
J Alfredo MartínezCIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Institute of Health, Madrid, Spain.ORCID http://orcid.org/0000-0001-5218-6941
Lluis Serra-MajemCIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Institute of Health, Madrid, Spain.ORCID http://orcid.org/0000-0002-9658-9061
Ramón EstruchCIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Institute of Health, Madrid, Spain.ORCID http://orcid.org/0000-0003-1260-4445
Francisco J TinahonesCIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Institute of Health, Madrid, Spain.ORCID http://orcid.org/0000-0001-6871-4403
José LapetraCIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Institute of Health, Madrid, Spain.ORCID http://orcid.org/0000-0002-3873-5737
Xavier PintóCIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Institute of Health, Madrid, Spain.ORCID http://orcid.org/0000-0002-2216-2444
Josep A TurCIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Institute of Health, Madrid, Spain.ORCID http://orcid.org/0000-0002-6940-0761
Antonio García-RíosCIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Institute of Health, Madrid, Spain.
Laura García-MolinaDepartment of Preventive Medicine and Public Health, University of Granada, Avda. De la Investigación 11, 18016, Granada, Spain.ORCID http://orcid.org/0000-0002-7358-6255
Miguel Delgado-RodríguezCIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.ORCID http://orcid.org/0000-0002-3838-2548
Pilar Matía-MartínDepartment of Endocrinology and Nutrition, Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISSC), Madrid, Spain.ORCID http://orcid.org/0000-0002-1424-8352
Lidia DaimielNutritional Genomics and Epigenomics Group, IMDEA Food, CEI UAM + CSIC, Madrid, Spain.ORCID http://orcid.org/0000-0001-9898-6629
Vicente Martín-SánchezCIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Josep VidalDepartment of Endocrinology, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0002-4564-4518
Clotilde VázquezCIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Institute of Health, Madrid, Spain.ORCID http://orcid.org/0000-0003-1629-2143
Emilio RosCIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Institute of Health, Madrid, Spain.ORCID http://orcid.org/0000-0002-2573-1294
Javier Bartolomé-ResanoDepartment of Preventive Medicine and Public Health, Medical School, University of Navarra, Pamplona, Spain.ORCID http://orcid.org/0000-0003-1818-3370
Antoni Palau-GalindoHuman Nutrition Unit, Biochemistry and Biotechnology Department, IISPV, Universitat Rovira i Virgili, Reus, Spain.
Olga PortolesCIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Institute of Health, Madrid, Spain.
Laura TorresUnit of Cardiovascular Risk and Nutrition, Hospital del Mar, Institut Municipal d'Investigació Médica (IMIM), Barcelona, Spain.
Miquel-FiolCIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Institute of Health, Madrid, Spain.ORCID http://orcid.org/0000-0002-5370-1391
María Teresa Cano SánchezCentro de Salud Santa Pola, Alicante, Spain.
Carolina Sorto-SánchezCIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Institute of Health, Madrid, Spain.
Noelia Moreno-MoralesDepartment of Physiotherapy, School of Health Sciences, University of Malaga-Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain.ORCID http://orcid.org/0000-0001-5907-9735
Itziar AbeteNavarra Institute for Health Research (IdisNa), Pamplona, Spain.ORCID http://orcid.org/0000-0002-6475-5387
Jacqueline Álvarez-PérezCIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Institute of Health, Madrid, Spain.ORCID http://orcid.org/0000-0001-5726-3731
Emilio SacanellaCIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Institute of Health, Madrid, Spain.
María Rosa Bernal-LópezCIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Institute of Health, Madrid, Spain.ORCID http://orcid.org/0000-0002-0238-0890
José Manuel Santos-LozanoCIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Institute of Health, Madrid, Spain.ORCID http://orcid.org/0000-0001-7097-5653
Marta Fanlo-MaresmaLipids and Vascular Risk Unit, Internal Medicine, Hospital Universitario de Bellvitge, IDIBELL, Hospitalet de Llobregat, Barcelona, Spain.
Cristina BouzasCIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Institute of Health, Madrid, Spain.ORCID http://orcid.org/0000-0002-1407-8461
Cristina RazquinDepartment of Preventive Medicine and Public Health, Medical School, University of Navarra, Pamplona, Spain.ORCID http://orcid.org/0000-0003-3480-2645
Nerea Becerra-TomásCIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Institute of Health, Madrid, Spain.ORCID http://orcid.org/0000-0002-4429-6507
Carolina Ortega-AzorinCIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Institute of Health, Madrid, Spain.
Regina LLimonaUnit of Cardiovascular Risk and Nutrition, Hospital del Mar, Institut Municipal d'Investigació Médica (IMIM), Barcelona, Spain.
Marga MoreyCIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Institute of Health, Madrid, Spain.
Josefa Román-MaciáCentro de Salud Santa Pola, Alicante, Spain.
Leire Goicolea-GüemezCIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Institute of Health, Madrid, Spain.
Zenaida Vázquez-RuizDepartment of Preventive Medicine and Public Health, Medical School, University of Navarra, Pamplona, Spain.ORCID http://orcid.org/0000-0002-6828-9627
Laura BarrubésCIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Institute of Health, Madrid, Spain.
Montse FitóCIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Institute of Health, Madrid, Spain.ORCID http://orcid.org/0000-0002-1817-483X
Alfredo GeaDepartment of Preventive Medicine and Public Health, Medical School, University of Navarra, Pamplona, Spain.ORCID http://orcid.org/0000-0002-2229-4690
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition · ESHospital Del Mar · ESUniversidad de Granada · ESUniversitat de València · ESUniversity of the Basque Country · ESInstituto de Salud Carlos III · ESMadrid Institute for Advanced Studies · ESUniversidad de Las Palmas de Gran Canaria · ESBellvitge University Hospital · ESHarvard University · USInstitut de Recerca Biomèdica Catalunya Sud · ESInstituto de Investigación Biomédica de Málaga · ESInstituto de Investigación Sanitaria del Hospital Clínico San Carlos · ESNavarre Institute of Health Research · ESServicio Navarro de Salud · ESUniversidad de Jaén · ESUniversitat de Miguel Hernández d'Elx · ES

Funding

MULTIDISCIPLINARY ENVIRONMENTAL HEALTH TRAININGD43TW000636 · FIC · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI CARPENTER, DAVID ORLO · 1995 to 2006
$1.5M
HUMAN HERPESVIRUS 8 INFECTION IN ZIMBABWER03TW001123 · FIC · UNIVERSITY OF COLORADO DENVER · PI CAMPBELL, THOMAS B. · 1999 to 2001
$81k
ALKYLATING &CLEAVING ANTIC-MYC DNAS FOR BREAST CANCERR03TW001094 · FIC · THOMAS JEFFERSON UNIVERSITY · PI WICKSTROM, ERIC · 1999 to 2001
$77k
RESEARCH COLLABORATION WITH MOSCOW STATE UNIVERSITYR03TW000492 · FIC · UNIVERSITY OF WASHINGTON · PI CRUM, LAWRENCE A · 1995 to 2001
$68k
MOLECULAR CLONING OF THE HUMAN C1Q RECEPTORF06TW001732 · FIC · STATE UNIVERSITY NEW YORK STONY BROOK · PI GHEBREHIWET, BERHANE · 1991 to 1991
–
MECHANISMS RESPONSIBLE FOR MODERATE AND SEVERE FLUOROSISF06TW001873 · FIC · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI BAWDEN, JAMES W · 1992 to 1992
–
DEVELOPMENT CHANGES IN SYNAPTIC PLASTICITYF06TW002184 · FIC · CHILDREN'S HOSPITAL BOSTON · PI HOLMES, GREGORY L · 1996 to 1996
–
RESEARCH IN BIOPHYSICSF15TW000272 · FIC · U.S. NATIONAL INSTITUTES OF HEALTH · PI USSING, HANS G · 1985 to 1985
–
MOLECULAR BIOLOGICAL STUDIES ON PEPTIDEF15TW000366 · FIC · U.S. FOGARTY INTERNATIONAL CENTER · PI LEEMAN, SUSAN E · 1994 to 1994
–
HIV-1 FROM ASYMPTOMATIC PATIENTSR03TW000532 · FIC · SCRIPPS RESEARCH INSTITUTE · PI MOSIER, DONALD E · 1995 to 1997
–
CONTINUING STUDY ON AIDS-RELATED OPPORTUNISTIC PATHOGENSR03TW000533 · FIC · SOUTHERN RESEARCH INSTITUTE · PI BARROW, WILLIAM · 1995 to 1997
–
BIOLOGY OF SIV IN THE AFRICAN GREEN MONKEYR03TW000764 · FIC · UNIVERSITY OF CALIFORNIA DAVIS · PI MILLER, CHRISTOPHER · 1996 to 1998
–
CIBEROBN, ISCIII CB06/03Consejería de Salud de la Junta de Andalucía PI0137/2018Consejería de Salud de la Junta de Andalucía PI0458/2013Consejería de Salud de la Junta de Andalucía PS0358/2016European Research Council 340918Generalitat Valenciana PROMETEO/2017/017International Nut&Dried Fruit Council- FESNAD 201302Ministry of Education of Spain FPU14/3630Official funding agency for biomedical research of the Spanish Government, ISCIII PI13/00233Official funding agency for biomedical research of the Spanish Government, ISCIII PI13/00272Official funding agency for biomedical research of the Spanish Government, ISCIII PI13/00462Official funding agency for biomedical research of the Spanish Government, ISCIII PI13/00492Official funding agency for biomedical research of the Spanish Government, ISCIII PI13/00673Official funding agency for biomedical research of the Spanish Government, ISCIII PI13/00728Official funding agency for biomedical research of the Spanish Government, ISCIII PI13/01056Official funding agency for biomedical research of the Spanish Government, ISCIII PI13/01090Official funding agency for biomedical research of the Spanish Government, ISCIII PI13/01123Official funding agency for biomedical research of the Spanish Government, ISCIII PI13/02184Official funding agency for biomedical research of the Spanish Government, ISCIII PI14/00618Official funding agency for biomedical research of the Spanish Government, ISCIII PI14/00636Official funding agency for biomedical research of the Spanish Government, ISCIII PI14/00696Official funding agency for biomedical research of the Spanish Government, ISCIII PI14/00853Official funding agency for biomedical research of the Spanish Government, ISCIII PI14/01206Official funding agency for biomedical research of the Spanish Government, ISCIII PI14/01374Official funding agency for biomedical research of the Spanish Government, ISCIII PI14/01722Official funding agency for biomedical research of the Spanish Government, ISCIII PI14/01919Official funding agency for biomedical research of the Spanish Government, ISCIII PI16/00366Official funding agency for biomedical research of the Spanish Government, ISCIII PI16/00381Official funding agency for biomedical research of the Spanish Government, ISCIII PI16/00473Official funding agency for biomedical research of the Spanish Government, ISCIII PI16/00501Official funding agency for biomedical research of the Spanish Government, ISCIII PI16/00533Official funding agency for biomedical research of the Spanish Government, ISCIII PI16/00662Official funding agency for biomedical research of the Spanish Government, ISCIII PI16/01094Official funding agency for biomedical research of the Spanish Government, ISCIII PI16/01120Official funding agency for biomedical research of the Spanish Government, ISCIII PI16/01522Official funding agency for biomedical research of the Spanish Government, ISCIII PI16/01873Official funding agency for biomedical research of the Spanish Government, ISCIII PI17/00215Official funding agency for biomedical research of the Spanish Government, ISCIII PI17/00508Official funding agency for biomedical research of the Spanish Government, ISCIII PI17/00525Official funding agency for biomedical research of the Spanish Government, ISCIII PI17/00532Official funding agency for biomedical research of the Spanish Government, ISCIII PI17/00764Official funding agency for biomedical research of the Spanish Government, ISCIII PI17/00855Official funding agency for biomedical research of the Spanish Government, ISCIII PI17/00926Official funding agency for biomedical research of the Spanish Government, ISCIII PI17/01183Official funding agency for biomedical research of the Spanish Government, ISCIII PI17/01347Official funding agency for biomedical research of the Spanish Government, ISCIII PI17/01441Official funding agency for biomedical research of the Spanish Government, ISCIII PI17/01732Official funding agency for biomedical research of the Spanish Government, ISCIII PI17/01827Recercaixa 2013ACUP00194
6 · The paper itself

Abstract

backgroundThe prevalence of overweight/obesity and related manifestations such as metabolic syndrome (MetS) is increasing worldwide. High energy density diets, usually with low nutrient density, are among the main causes. Some high-quality dietary patterns like the Mediterranean diet (MedDiet) have been linked to the prevention and better control of MetS. However, it is needed to show that nutritional interventions promoting the MedDiet are able to improve nutrient intake.

objectiveTo assess the effect of improving MedDiet adherence on nutrient density after 1 year of follow-up at the PREDIMED-Plus trial.

methodsWe assessed 5777 men (55-75 years) and women (60-75 years) with overweight or obesity and MetS at baseline from the PREDIMED-Plus trial. Dietary changes and MedDiet adherence were evaluated at baseline and after 1 year. The primary outcome was the change in nutrient density (measured as nutrient intake per 1000 kcal). Multivariable-adjusted linear regression models were fitted to analyse longitudinal changes in adherence to the MedDiet and concurrent changes in nutrient density.

resultsDuring 1-year follow-up, participants showed improvements in nutrient density for all micronutrients assessed. The density of carbohydrates (- 9.0%), saturated fatty acids (- 10.4%) and total energy intake (- 6.3%) decreased. These changes were more pronounced in the subset of participants with higher improvements in MedDiet adherence.

conclusionsThe PREDIMED-Plus dietary intervention, based on MedDiet recommendations for older adults, maybe a feasible strategy to improve nutrient density in Spanish population at high risk of cardiovascular disease with overweight or obesity.

Indexed as

Diet, MediterraneanNutritional StatusAgedCardiovascular DiseasesFemaleFollow-Up StudiesHumansMaleMetabolic SyndromeMiddle AgedObesityOverweightRisk FactorsSpainTime FactorsMediterranean dietMetabolic syndromeNutrient density

Identifiers

PMID31523780
OpenAlexW2973051161

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.