Trial reportBehavioural brain research2020
Dopamine replacement improves motor learning of an upper extremity task in people with Parkinson disease.
Trial report in Behavioural brain research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Clinical assessment of upper limb impairments and functional capacity in Parkinson's disease: a systematic review.Arquivos de neuro-psiquiatria · 2023Pooled it
- Effect of dual-task interference on upper extremity motor experience with Parkinson's disease motor effect of dual-task in Parkinson's disease.BMC neurology · 2025Trial
- Trial
- Transcranial direct current stimulation enhances motor learning in Parkinson's disease: a randomized controlled trial.Journal of neurology · 2023Trial
- The onset of motor learning impairments in Parkinson's disease: a computational investigation.Brain informatics · 2024Article
- Learning critically drives parkinsonian motor deficits through imbalanced striatal pathway recruitment.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Finger dexterity measured by the Grooved Pegboard test indexes Parkinson's motor severity in a tremor-independent manner.Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology · 2022Article
- Remote, Unsupervised Functional Motor Task Evaluation in Older Adults across the United States Using the MindCrowd Electronic Cohort.Developmental neuropsychology · 2021Article
- Neuropsychiatric and Cognitive Deficits in Parkinson's Disease and Their Modeling in Rodents.Biomedicines · 2021Review
- How Common Is the Exponential Decay Pattern of Motor Skill Acquisition? A Brief Investigation.Motor control · 2021Article
- Challenging the relationship of grip strength with cognitive status in older adults.International journal of geriatric psychiatry · 2021Article
- Relating Global Cognition With Upper-Extremity Motor Skill Retention in Individuals With Mild-to-Moderate Parkinson's Disease.Frontiers in rehabilitation sciences · 2021Article
- Neurotransmitters, Cell Types, and Circuit Mechanisms of Motor Skill Learning and Clinical Applications.Frontiers in neurology · 2021Review
- High-Fat Diet-Induced Weight Gain, Behavioral Deficits, and Dopamine Changes in Young C57BL/6J Mice.Frontiers in nutrition · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundDopamine replacement medication has positive effects on existing motor skills for people with Parkinson disease (PD), but may have detrimental effects on the learning of motor skills necessary for effective rehabilitation according to the dopamine overdose hypothesis.
objectivesThis study aimed to determine whether dopamine replacement medication (i.e. levodopa) affects: learning of a novel upper extremity task, decrements in skill following withdrawal of practice, the rate of learning, and the transfer of movement skill to untrained upper extremity tasks compared to training "off" medication, in people with PD.
methodsParticipants with mild-moderate PD (Hoehn and Yahr stage 2) were randomized to train "on" (n = 12) or "off" (n = 11) levodopa medication. Participants practiced 10 blocks of five trials of a functional motor task with their non-dominant upper extremity over three consecutive days (acquisition period), followed by a single block of five trials two and nine days later. Participants were also assessed "on" levodopa with two transfer tasks (the nine-hole peg test and a functional dexterity task) prior to any practice and nine days after the end of the acquisition period.
resultsParticipants who practiced "on" levodopa medication learned the upper extremity task to a greater extent that those who practiced "off" medication, as determined by retained performance two days after practice. Skill decrement and skill transfer were not significantly different between groups. Rate of learning was unable to be modelled in this sample.
conclusionsLevodopa medication improved the learning of an upper extremity task in people with mild-moderate PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.