Evidence map›Paper›PMID 31527585›Full record

ArticleTranslational psychiatry2019

Clinical and genetic validity of quantitative bipolarity.

Heather A Bruce, Peter Kochunov, Braxton Mitchell, Kevin A Strauss, Seth A Ament, Laura M Rowland, Xiaoming Du, Feven Fisseha, Thangavelu Kavita, Joshua Chiappelli and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Heather A BruceMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, 21228, USA. hbruce@mprc.umaryland.edu.
Peter KochunovMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, 21228, USA.
Braxton MitchellDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21228, USA.
Kevin A StraussClinic for Special Children, Strasburg, PA, 17579, USA.
Seth A AmentMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, 21228, USA.ORCID http://orcid.org/0000-0001-6443-7509
Laura M RowlandMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, 21228, USA.
Xiaoming DuMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, 21228, USA.
Feven FissehaMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, 21228, USA.
Thangavelu KavitaMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, 21228, USA.
Joshua ChiappelliMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, 21228, USA.
Krista WisnerMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, 21228, USA.
Hemalatha SampathMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, 21228, USA.
Shuo ChenMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, 21228, USA.
Mark D KvartaMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, 21228, USA.ORCID http://orcid.org/0000-0002-1093-1648
Chamindi SeneviratneDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, 21228, USA.
Teodor T PostolacheDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, 21228, USA.
Alfredo BellonHershey Medical Center, Department of Psychiatry, Penn State University School of Medicine, Hershey, PA, 17033, USA.
Francis J McMahonHuman Genetics Branch, National Institute of Mental Health Intramural Research Program, Bethesda, MD, 20892, USA.ORCID http://orcid.org/0000-0002-9469-305X
Alan ShuldinerDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21228, USA.
L Elliot HongMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, 21228, USA.

Funding

The Effects of Kynurenine Aminotransferase Inhibition in People with SchizophreniaP50MH103222 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI BUCHANAN, ROBERT W · 2014 to 2023
$25.2M
SOLAR-Eclipse Computational Tools for Imaging GeneticsR01EB015611 · NIBIB · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KOCHUNOV, PETER V. · 2012 to 2024
$5.0M
Multidisciplinary Schizophrenia Research TrainingT32MH067533 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI CARPENTER, WILLIAM T., ELMER, GREGORY I · 2004 to 2025
$4.3M
Amish Connectome Project on Mental IllnessU01MH108148 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI HONG, L ELLIOT ELLIOT, KOCHUNOV, PETER V. · 2015 to 2018
$4.3M
Shared Neural Circuitry in Comorbid Schizophrenia and Nicotine AddictionR01DA027680 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI HONG, L ELLIOT ELLIOT · 2010 to 2014
$2.4M
A Multivariate Mediation and Deep Learning Framework for Genome-Connectome -Substance Use ResearchDP1DA048968 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI CHEN, SHUO · 2019 to 2023
$2.3M
Neural Oscillatory Biomarkers for Genetics and Animal Models of SchizophreniaR01MH085646 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI HONG, L ELLIOT ELLIOT · 2010 to 2013
$2.2M
Hybrid GPU/CPU Computing Resource to Support Connectomic and GenomicsS10OD023696 · OD · UNIVERSITY OF MARYLAND BALTIMORE · PI KOCHUNOV, PETER V. · 2018 to 2018
$593k
NIBIB NIH HHS R01 EB015611NIDA NIH HHS DP1 DA048968NIDA NIH HHS R01 DA027680NIH HHS S10 OD023696NIMH NIH HHS P50 MH103222NIMH NIH HHS R01 MH085646NIMH NIH HHS T32 MH067533NIMH NIH HHS U01 MH108148
6 · The paper itself

Abstract

Research has yet to provide a comprehensive understanding of the genetic basis of bipolar disorder (BP). In genetic studies, defining the phenotype by diagnosis may miss risk-allele carriers without BP. The authors aimed to test whether quantitatively detected subclinical symptoms of bipolarity identifies a heritable trait that infers risk for BP. The Quantitative Bipolarity Scale (QBS) was administered to 310 Old Order Amish or Mennonite individuals from multigenerational pedigrees; 110 individuals had psychiatric diagnoses (20 BP, 61 major depressive disorders (MDD), 3 psychotic disorders, 26 other psychiatric disorders). Familial aggregation of QBS was calculated using the variance components method to derive heritability and shared household effects. The QBS score was significantly higher in BP subjects (31.5 ± 3.6) compared to MDD (16.7 ± 2.0), other psychiatric diagnoses (7.0 ± 1.9), and no psychiatric diagnosis (6.0 ± 0.65) (all p < 0.001). QBS in the whole sample was significantly heritable (h

Indexed as

AllelesGenetic Predisposition to DiseaseGenotypePhenotypeAdultBipolar DisorderFemaleHumansMajor Depressive DisorderMaleMiddle AgedPedigreePsychiatric Status Rating ScalesYoung Adult

Identifiers

PMID31527585
PMCPMC6746871

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.