Trial reportJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2021
Effects of cardiac rehabilitation with and without meditation on myocardial blood flow using quantitative positron emission tomography: A pilot study.
Trial report in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01810029 (A Randomized Controlled Trial of Stress Reduction in the Secondary Prevention of Coronary Heart Disease in African Americans), which is not on this map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Controlled Trial of Stress Reduction in the Secondary Prevention of Coronary Heart Disease in African Americans
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Meditation for the primary and secondary prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2024Pooled it
- Effectiveness of Mantra-Based Meditation on Mental Health: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Effect of a single ultra processed meal on myocardial endothelial function, adenosine mediated effects and cognitive performances.Scientific reports · 2025Trial
- Comprehensive Review of Chronic Stress Pathways and the Efficacy of Behavioral Stress Reduction Programs (BSRPs) in Managing Diseases.International journal of environmental research and public health · 2024Review
- Heart-brain axis: Pushing the boundaries of cardiovascular molecular imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2024Review
- Effects of Static Meditation Practice on Blood Lipid Levels: A Systematic Review and Meta-Analysis.Healthcare (Basel, Switzerland) · 2024Review
- Coronary microvascular function in male physicians with burnout and job stress: an observational study.BMC medicine · 2023Observational
- Effects of Meditation on Cardiovascular and Muscular Responses in Patients during Cardiac Rehabilitation: A Randomized Pilot Study.Journal of clinical medicine · 2022Article
- LASSO Homotopy-Based Sparse Representation Classification for fNIRS-BCI.Sensors (Basel, Switzerland) · 2022Article
- Meditation in cardiac rehabilitation: Should we be thinking about it?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- New Ultrasound Technologies for Ischemic Heart Disease Assessment and Monitoring in Cardiac Rehabilitation.Journal of clinical medicine · 2020Review
- Disentangling the Links Between Psychosocial Stress and Cardiovascular Disease.Circulation. Cardiovascular imaging · 2020Review
- Coronary vasomotion and exercise-induced adaptations in coronary artery disease patients: A systematic review and meta-analysis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2020Review
- Addressing Clinician Burnout: A Unifying Systems Medicine Model with Meditation as a Heart-mind Intervention.Heart and mind (Mumbai, India)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPsychosocial stress is recognized as a risk factor for coronary heart disease (CHD). High rates of CHD in African-Americans may be related to psychosocial stress. However, standard cardiac rehabilitation (CR) usually does not include a systematic stress-reduction technique. Previous studies suggest that the Transcendental Meditation (TM) technique may reduce CHD risk factors and clinical events. This pilot study explored the effects of standard CR with and without TM on a measure of CHD in African-American patients.
methodsFifty-six CHD patients were assigned to CR, CR + TM, TM alone, or usual care. Testing was done at baseline and after 12 weeks. The primary outcome was myocardial flow reserve (MFR) assessed by
resultsFor 37 patients who completed posttesting, there were MFR improvements in the CR + TM group (+20.7%; ES = 0.64) and the TM group alone (+12.8%; ES = 0.36). By comparison, the CR-alone and usual care groups showed modest changes (+ 5.8%; ES = 0.17 and - 10.3%; ES = - 0.31), respectively. For the combined TM group, MFR increased (+ 14%, ES = 0.56) compared to the combined non-TM group (- 2.0%, ES = - 0.08).
conclusionsThese pilot data suggest that adding the TM technique to standard cardiac rehabilitation or using TM alone may improve the myocardial flow reserve in African-American CHD patients. These results may be applied to the design of controlled clinical trials to definitively test these effects.
trial registrationClinicalTrials.gov registration # NCT01810029.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.