Evidence map›Paper›PMID 31530014›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Direct pulmonary delivery of solubilized curcumin reduces severity of lethal pneumonia.

Boya Zhang, Samantha Swamy, Sanjay Balijepalli, Sreehari Panicker, Jashitha Mooliyil, Matthew A Sherman, Jaakko Parkkinen, Krishnan Raghavendran, Madathilparambil V Suresh

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 54 citations in OpenAlex.

  1. Trial
  2. Review
  3. Advances in anti-inflammatory treatment of sepsis-associated acute respiratory distress syndrome.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Review
  4. Review
  5. Review
  6. Article
  7. Therapeutic potential of curcumin in ARDS and COVID-19.Clinical and experimental pharmacology & physiology · 2023
    Review
  8. The Effects of Curcumin on Inflammasome: Latest Update.Molecules (Basel, Switzerland) · 2023
    Review
  9. Article
  10. Article
  11. Can natural products modulate cytokine storm in SARS-CoV2 patients?Biotechnology reports (Amsterdam, Netherlands) · 2022
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Photoactive Thin-Film Structures of Curcumin, TiOMolecules (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Boya ZhangDepartment of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Samantha SwamyDepartment of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Sanjay BalijepalliDepartment of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Sreehari PanickerDepartment of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Jashitha MooliyilDepartment of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Matthew A ShermanDepartment of Pediatrics, Children's National Medical Center, Washington, DC, USA.
Jaakko ParkkinenInstitute of Biomedicine, University of Helsinki, Helsinki, Finland.
Krishnan RaghavendranDepartment of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Madathilparambil V SureshDepartment of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
University of Michigan–Ann Arbor · USChildren's National · USUniversity of Helsinki · FI

Funding

Regulation of Hypoxia Inducible Factor -1α in Alveolar Epithelial Cells in Lung ContusionR01GM111305 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAGHAVENDRAN, KRISHNAN · 2015 to 2018
$1.3M
NIGMS NIH HHS R01 GM111305
6 · The paper itself

Abstract

Acute respiratory distress syndrome (ARDS), the most severe form of acute lung injury, is associated with reduced lung compliance and hypoxemia. Curcumin exhibits potent anti-inflammatory properties but has poor solubility and rapid plasma clearance. To overcome these physiochemical limitations and uncover the full therapeutic potential of curcumin in lung inflammation, in this study we utilized a novel water-soluble curcumin formulation (CDC) and delivered it directly into the lungs of C57BL/6 mice inoculated with a lethal dose of

Indexed as

Acute Lung InjuryAnimalsAnti-Inflammatory AgentsCurcuminFemaleHumansKlebsiella InfectionsKlebsiella pneumoniaeLungMaleMiceMice, Inbred C57BLNF-kappa BOxidative StressPneumoniaPneumonia, BacterialAnti-Inflammatory AgentsCurcuminNF-kappa Bapoptosiscapillary Western blotmacrophagesMTTphagocytosis

Identifiers

PMID31530014
PMCPMC6894047
OpenAlexW2973918379

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.