Evidence map›Paper›PMID 31537150›Full record

ArticleCell cycle (Georgetown, Tex.)2019

HIF1α/miR-199a/ADM feedback loop modulates the proliferation of human dermal microvascular endothelial cells (HDMECs) under hypoxic condition.

Yang Sun, Xiang Xiong, Xiancheng Wang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. GATA1 knockdown enhances CD8Journal of molecular histology · 2026
    Article
  2. Adrenomedullin in Tumorigenesis and Cancer Progression.International journal of molecular sciences · 2025
    Review
  3. Article
  4. Dermal Microvascular Units in Domestic Pigs (Frontiers in veterinary science · 2022
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Yang SunDepartment of plastic surgery and burns surgery, The Second Xiangya Hospital, Central South University , Changsha , Hunan , China.
Xiang XiongDepartment of plastic surgery and burns surgery, The Second Xiangya Hospital, Central South University , Changsha , Hunan , China.
Xiancheng WangDepartment of plastic surgery and burns surgery, The Second Xiangya Hospital, Central South University , Changsha , Hunan , China.
Central South University · CNSecond Xiangya Hospital of Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypoxia-inducible factor 1α (HIF1α) plays a protective role in the hypoxia-induced cellular injury. In the present study, we attempted to investigate the role and mechanism of HIF1αin human dermal microvascular endothelial cells (hDMECs), a common-used cell model for researches on the hypoxia-induced injury during skin wounds healing. As revealed by ChIP and online tools prediction and confirmed by luciferase reporter and ChIP assays, HIF1A can bind to the promoter regions of

Indexed as

AdrenomedullinCapillary PermeabilityCell LineCell MovementCell ProliferationEndothelial CellsHumansHypoxiaHypoxia-Inducible Factor 1, alpha SubunitInterleukin-8MicroRNAsPromoter Regions, GeneticTranscription Factor RelATumor Necrosis Factor-alphaWound HealingADM protein, humanAdrenomedullinCXCL8 protein, humanHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitInterleukin-8MicroRNAsmirn199 microRNA, humanRELA protein, humanTranscription Factor RelATumor Necrosis Factor-alphaadrenomedullin (ADM)human dermal microvascular endothelial cells (HDMECs)HypoxiaHypoxia-inducible factor 1α (HIF1A)miR-199a

Identifiers

PMID31537150
PMCPMC6791693
OpenAlexW2974143440

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.