Evidence map›Paper›PMID 31546575›Full record

ArticleProteomes2019

In Silico Identification of Antimicrobial Peptides in the Proteomes of Goat and Sheep Milk and Feta Cheese.

Marios Tomazou, Anastasis Oulas, Athanasios K Anagnostopoulos, George Th Tsangaris, George M Spyrou

Open access · goldAbstract read
In one paragraph

Article in Proteomes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Review
  3. Mining the UniProtKB/Swiss-Prot database for antimicrobial peptides.Protein science : a publication of the Protein Society · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Frontiers in immunology · 2023
    Review
  8. Article
  9. Antimicrobial Peptides: From Design to Clinical Application.Antibiotics (Basel, Switzerland) · 2022
    Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Marios TomazouThe Cyprus Institute of Neurology & Genetics, Bioinformatics Group, 6 International Airport Avenue, 2370 Nicosia, Cyprus, P.O. Box 23462, 1683 Nicosia, Cyprus. mariost@cing.ac.cy.ORCID 0000-0002-0836-5579
Anastasis OulasThe Cyprus Institute of Neurology & Genetics, Bioinformatics Group, 6 International Airport Avenue, 2370 Nicosia, Cyprus, P.O. Box 23462, 1683 Nicosia, Cyprus. anastasioso@cing.ac.cy.
Athanasios K AnagnostopoulosProteomics Research Unit, Biomedical Research Foundation of the Academy of Athens, 115 27 Athens, Greece. atanagnost@bioacademy.gr.
George Th TsangarisProteomics Research Unit, Biomedical Research Foundation of the Academy of Athens, 115 27 Athens, Greece. gthtsangaris@bioacademy.gr.
George M SpyrouThe Cyprus Institute of Neurology & Genetics, Bioinformatics Group, 6 International Airport Avenue, 2370 Nicosia, Cyprus, P.O. Box 23462, 1683 Nicosia, Cyprus. georges@cing.ac.cy.
Cyprus Institute of Neurology and Genetics · CYBiomedical Research Foundation of the Academy of Athens · GR

Funding

European Commission 669026
6 · The paper itself

Abstract

Milk and dairy products are a major functional food group of growing scientific and commercial interest due to their nutritional value and bioactive "load". A major fraction of the latter is attributed to milk's rich protein content and its biofunctional peptides that occur naturally during digestion. On the basis of the identified proteome datasets of milk whey from sheep and goat breeds in Greece and feta cheese obtained during previous work, we applied an in silico workflow to predict and characterise the antimicrobial peptide content of these proteomes. We utilised existing tools for predicting peptide sequences with antimicrobial traits complemented by in silico protein cleavage modelling to identify frequently occurring antimicrobial peptides (AMPs) in the gastrointestinal (GI) tract in humans. The peptides of interest were finally assessed for their stability with respect to their susceptibility to cleavage by endogenous proteases expressed along the intestinal part of the GI tract and ranked with respect to both their antimicrobial and stability scores.

Indexed as

antimicrobial peptidesfunctional foodsgastrointestinal tractin silico digestionmilk wheypeptidomicsproteasesproteolysisproteomics

Identifiers

PMID31546575
PMCPMC6958355
OpenAlexW2974469476

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.