Evidence map›Paper›PMID 31548374›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

DDX5 helicase resolves G-quadruplex and is involved in

Guanhui Wu, Zheng Xing, Elizabeth J Tran, Danzhou Yang

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 123 citations in OpenAlex.

  1. Article
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  10. Microprotein Regulates G-quadruplex Driven RNA Aggregation.bioRxiv : the preprint server for biology · 2026
    Article
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  13. Review
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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Guanhui WuDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.ORCID 0000-0003-4659-8717
Zheng XingDepartment of Biochemistry, Purdue University, West Lafayette, IN 47907.
Elizabeth J TranDepartment of Biochemistry, Purdue University, West Lafayette, IN 47907; ejtran@purdue.edu yangdz@purdue.edu.ORCID 0000-0002-9541-004X
Danzhou YangDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907; ejtran@purdue.edu yangdz@purdue.edu.
Purdue University West Lafayette · US

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI ANDREW D MESECAR · 1985 to 2026
$43.4M
The Role of DEAD-box Proteins in Gene ExpressionR01GM097332 · NIGMS · PURDUE UNIVERSITY · PI TRAN, ELIZABETH J · 2011 to 2025
$4.1M
Targeting MYC promoter G-quadruplex for MYC inhibition by IndenoisoquinolinesR01CA177585 · NCI · UNIVERSITY OF ARIZONA · PI SINTIM, HERMAN O, YANG, DANZHOU · 2014 to 2025
$4.0M
G-quadruplexes formed in human oncogene promoters and their drug complexesR01CA122952 · NCI · UNIVERSITY OF ARIZONA · PI YANG, DANZHOU · 2007 to 2011
$875k
NCI NIH HHS P30 CA023168NCI NIH HHS R01 CA122952NCI NIH HHS R01 CA177585NIGMS NIH HHS R01 GM097332
6 · The paper itself

Abstract

G-quadruplexes (G4) are noncanonical secondary structures formed in guanine-rich DNA and RNA sequences.

Indexed as

G-QuadruplexesCell LineChromatinDEAD-box RNA HelicasesGene Expression RegulationHumansNucleic AcidsProtein UnfoldingProto-Oncogene Proteins c-mycChromatinDdx5 protein, humanDEAD-box RNA HelicasesDHX36 protein, humanNucleic AcidsProto-Oncogene Proteins c-myccancer drug targetDDX5G4-helicaseG-quadruplexMYC

Identifiers

PMID31548374
PMCPMC6789965
OpenAlexW2976449702

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.