Evidence map›Paper›PMID 31549940›Full record

ArticleCirculation research2019

Diversification and CXCR4-Dependent Establishment of the Bone Marrow B-1a Cell Pool Governs Atheroprotective IgM Production Linked to Human Coronary Atherosclerosis.

Aditi Upadhye, Prasad Srikakulapu, Ayelet Gonen, Sabrina Hendrikx, Heather M Perry, Anh Nguyen, Chantel McSkimming, Melissa A Marshall, James C Garmey, Angela M Taylor and 6 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 65 citations in OpenAlex.

  1. Trial
  2. Article
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  4. Review
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  6. Article
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  10. Review
  11. Tipping the Scale: Atheroprotective IgM-Producing B Cells in Atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2024
    Review
  12. Article
  13. Review
  14. Review
  15. B cells and atherosclerosis: A HIV perspective.Journal of cellular physiology · 2024
    Review
  16. Article
  17. Review
  18. Review
  19. Atherosclerosis antigens as targets for immunotherapy.Nature cardiovascular research · 2023
    Review
  20. Human circulating CD24Nature cardiovascular research · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Aditi UpadhyeFrom the Cardiovascular Research Center (A.U., P.S., H.M.P., A.N., C.M., M.A.M., J.C.G, A.M.T., C.A.M.), University of Virginia, Charlottesville.
Prasad SrikakulapuFrom the Cardiovascular Research Center (A.U., P.S., H.M.P., A.N., C.M., M.A.M., J.C.G, A.M.T., C.A.M.), University of Virginia, Charlottesville.
Ayelet GonenDepartment of Medicine, University of California San Diego, La Jolla (A.G., S.H., S.T., J.L.W.).
Sabrina HendrikxDepartment of Medicine, University of California San Diego, La Jolla (A.G., S.H., S.T., J.L.W.).
Heather M PerryFrom the Cardiovascular Research Center (A.U., P.S., H.M.P., A.N., C.M., M.A.M., J.C.G, A.M.T., C.A.M.), University of Virginia, Charlottesville.
Anh NguyenFrom the Cardiovascular Research Center (A.U., P.S., H.M.P., A.N., C.M., M.A.M., J.C.G, A.M.T., C.A.M.), University of Virginia, Charlottesville.
Chantel McSkimmingFrom the Cardiovascular Research Center (A.U., P.S., H.M.P., A.N., C.M., M.A.M., J.C.G, A.M.T., C.A.M.), University of Virginia, Charlottesville.
Melissa A MarshallFrom the Cardiovascular Research Center (A.U., P.S., H.M.P., A.N., C.M., M.A.M., J.C.G, A.M.T., C.A.M.), University of Virginia, Charlottesville.
James C GarmeyFrom the Cardiovascular Research Center (A.U., P.S., H.M.P., A.N., C.M., M.A.M., J.C.G, A.M.T., C.A.M.), University of Virginia, Charlottesville.
Angela M TaylorFrom the Cardiovascular Research Center (A.U., P.S., H.M.P., A.N., C.M., M.A.M., J.C.G, A.M.T., C.A.M.), University of Virginia, Charlottesville.
Timothy P BenderDepartment of Microbiology, Immunology, Cancer Biology (A.U., T.P.B.), University of Virginia, Charlottesville.
Sotirios TsimikasDepartment of Medicine, University of California San Diego, La Jolla (A.G., S.H., S.T., J.L.W.).
Nichol E HolodickCenter for Immunobiology and Department of Biomedical Sciences, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo MI (N.E.H., T.L.R.).
Thomas L RothsteinCenter for Immunobiology and Department of Biomedical Sciences, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo MI (N.E.H., T.L.R.).
Joseph L WitztumDepartment of Medicine, University of California San Diego, La Jolla (A.G., S.H., S.T., J.L.W.).
Coleen A McNamaraFrom the Cardiovascular Research Center (A.U., P.S., H.M.P., A.N., C.M., M.A.M., J.C.G, A.M.T., C.A.M.), University of Virginia, Charlottesville.
University of Virginia · USUniversity of California, San Diego · USCarter Center · US

Funding

ROLE OF LIPOXYGENASES IN ATHEROGENESIS IN DIABETES MELLITUSP01HL055798 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI HEDRICK, CATHERINE C · 1995 to 2016
$28.4M
Project 4: APOB-specific CD4 and CD8 T cells exacerbate atherosclerosisP01HL136275 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Catherine C Hedrick · 2017 to 2026
$25.5M
INTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007496 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Michael G. Brown, Coleen A McNamara · 1995 to 2026
$10.2M
Local B-1 Regulation of AtherosclerosisR01HL136098 · NHLBI · UNIVERSITY OF VIRGINIA · PI MCNAMARA, COLEEN A · 2017 to 2020
$3.1M
Human B1-like Cells and Pneumococcal Defense in the ElderlyR01AI142004 · NIAID · WESTERN MICHIGAN UNIV SCHOOL OF MEDICINE · PI ROTHSTEIN, THOMAS L · 2019 to 2023
$1.9M
Genetic Regulation of B Lymphocyte Aortic Homing and AtheroprotectionR01HL107490 · NHLBI · UNIVERSITY OF VIRGINIA · PI MCNAMARA, COLEEN A · 2011 to 2014
$1.5M
Id3/B Lymphocytes and AtherosclerosisR01HL096447 · NHLBI · UNIVERSITY OF VIRGINIA · PI MCNAMARA, COLEEN A · 2009 to 2010
$1.0M
NHLBI NIH HHS P01 HL055798NHLBI NIH HHS P01 HL136275NHLBI NIH HHS P01 HL136275-01NHLBI NIH HHS R01 HL096447NHLBI NIH HHS R01 HL107490NHLBI NIH HHS R01 HL136098NIAID NIH HHS R01 AI142004NIAID NIH HHS T32 AI007496
6 · The paper itself

Abstract

rationaleB-1 cell-derived natural IgM antibodies against oxidation-specific epitopes on low-density lipoprotein are anti-inflammatory and atheroprotective. Bone marrow (BM) B-1a cells contribute abundantly to IgM production, yet the unique repertoire of IgM antibodies generated by BM B-1a and the factors maintaining the BM B-1a population remain unexplored. CXCR4 (C-X-C motif chemokine receptor 4) has been implicated in human cardiovascular disease and B-cell homeostasis, yet the role of B-1 cell CXCR4 in regulating atheroprotective IgM levels and human cardiovascular disease is unknown.

objectiveTo characterize the BM B-1a IgM repertoire and to determine whether CXCR4 regulates B-1 production of atheroprotective IgM in mice and humans. METHODS AND

resultsSingle-cell sequencing demonstrated that BM B-1a cells from aged ApoE

conclusionsThese data provide the first report of a unique BM B-1a cell IgM repertoire and identifies CXCR4 expression as a critical factor selectively governing BM B-1a localization and production of IgM against oxidation specific epitopes. That CXCR4 expression on human B-1 cells was greater in humans with low coronary artery plaque burden suggests a potential targeted approach for immune modulation to limit atherosclerosis.

Indexed as

AnimalsB-Lymphocyte SubsetsBone Marrow CellsCoronary Artery DiseaseHumansImmunoglobulin MMiceMice, Inbred C57BLMice, TransgenicReceptors, CXCR4CXCR4 protein, humanImmunoglobulin MReceptors, CXCR4atherosclerosisbone marrowcardiovascular diseaseimmunoglobulin Minflammation

Identifiers

PMID31549940
PMCPMC6830526
OpenAlexW2976841219

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.