Evidence map›Paper›PMID 31555146›Full record

ArticleFrontiers in physiology2019

Circular RNA Expression Profiling and Selection of Key Circular RNAs in the Hypothalamus of Heat-Acclimated Rats.

Lijun Fan, Gaihong An, Shang Wang, Xuewei Chen, Ying Liu, Zhifeng Liu, Qiang Ma, Jing Wang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Noncoding RNAs in apoptosis: identification and function.Turkish journal of biology = Turk biyoloji dergisi · 2022
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Lijun FanDepartment of Operational Medicine, Tianjin Institute of Environmental and Operational Medicine, Tianjin, China.
Gaihong AnDepartment of Operational Medicine, Tianjin Institute of Environmental and Operational Medicine, Tianjin, China.
Shang WangDepartment of Operational Medicine, Tianjin Institute of Environmental and Operational Medicine, Tianjin, China.
Xuewei ChenDepartment of Operational Medicine, Tianjin Institute of Environmental and Operational Medicine, Tianjin, China.
Ying LiuDepartment of Operational Medicine, Tianjin Institute of Environmental and Operational Medicine, Tianjin, China.
Zhifeng LiuDepartment of Intensive Care Medicine, General Hospital of Southern Theatre Command of People's Liberation Army, Guangzhou, China.
Qiang MaDepartment of Operational Medicine, Tianjin Institute of Environmental and Operational Medicine, Tianjin, China.
Jing WangDepartment of Operational Medicine, Tianjin Institute of Environmental and Operational Medicine, Tianjin, China.
Tianjin Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNAs (circRNAs) have vital roles in great variety of biological processes. However, expression levels and functions of circRNAs related to heat acclimation (HA) are poorly understood. This study is the first time an in-depth circRNA expression profiling were used to investigate circRNA-miRNA interactions in HA rats in order to further comprehend the mechanisms underlying HA. CircRNA expression profile was performed in rats' hypothalamus of HA and control group with microarray assays and their functions were predicted by using Bioinformatics analysis. Differential circRNAs and their regulated downstream miRNAs and mRNAs were quantitatively validated by means of quantitative polymerase chain reaction in real-time (RT-qPCR). Enzyme-linked immunosorbent assay (ELISA) was then applied to predict the expression of proteins. In total, 53 circRNAs were expressed distinctively between the HA and Control; up- and down-regulation of circRNAs were 28 and 25, respectively, in HA (fold change > 1.5,

Indexed as

circRNAsheat acclimationhigh-throughput RNA sequencing technologymicroRNAmRNA

Identifiers

PMID31555146
PMCPMC6722210
OpenAlexW2968315496

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.