Evidence map›Paper›PMID 31556149›Full record

ReviewSynapse (New York, N.Y.)2020

Homeostatic control of Drosophila neuromuscular junction function.

C Andrew Frank, Thomas D James, Martin Müller

Open access · hybridAbstract readReview
In one paragraph

Review in Synapse (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 89 citations in OpenAlex.

  1. Article
  2. Article
  3. Temporal and Cell-Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Article
  5. Article
  6. Nonionic signaling rapidly remodels postsynaptic DLG to induce retrograde homeostatic plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Active Zone Maturation Controls Presynaptic Output and Release Mode and Is Regulated by Neuronal Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  8. Activity-Dependent Increases in Quantal Size at theJournal of developmental biology · 2025
    Article
  9. Review
  10. Genetic dissection of theMolecular biology of the cell · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
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  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

C Andrew FrankDepartment of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.ORCID 0000-0001-9599-421X
Thomas D JamesDepartment of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.ORCID 0000-0003-0949-4783
Martin MüllerInstitute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.ORCID 0000-0003-1624-6761
University of Iowa · USUniversity of Zurich · CH

Funding

NEUROSCIENCE TRAINING PROGRAMT32NS007421 · NINDS · UNIVERSITY OF IOWA · PI Sheila A Baker, Daniel T. Tranel · 1999 to 2026
$6.0M
Synaptic signals that drive the long-term maintenance of homeostatic neuroplasticityR01NS085164 · NINDS · UNIVERSITY OF IOWA · PI FRANK, CARL ANDREW · 2017 to 2021
$1.5M
NINDS NIH HHS R01 NS085164NINDS NIH HHS T32 NS007421
6 · The paper itself

Abstract

The ability to adapt to changing internal and external conditions is a key feature of biological systems. Homeostasis refers to a regulatory process that stabilizes dynamic systems to counteract perturbations. In the nervous system, homeostatic mechanisms control neuronal excitability, neurotransmitter release, neurotransmitter receptors, and neural circuit function. The neuromuscular junction (NMJ) of Drosophila melanogaster has provided a wealth of molecular information about how synapses implement homeostatic forms of synaptic plasticity, with a focus on the transsynaptic, homeostatic modulation of neurotransmitter release. This review examines some of the recent findings from the Drosophila NMJ and highlights questions the field will ponder in coming years.

Indexed as

AnimalsDrosophilaHomeostasisNeuromuscular JunctionNeuronal PlasticitySynaptic Transmissionhomeostatic plasticityneurotransmitter releasepresynaptic mechanismssynaptic plasticitytranssynaptic signalling

Identifiers

PMID31556149
PMCPMC6817395
OpenAlexW2976025046

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.