ReviewInternational journal of molecular sciences2019
Relationship Between Intermittent Hypoxia and Type 2 Diabetes in Sleep Apnea Syndrome.
Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Association between obstructive sleep apnea syndrome and type1/type2 diabetes mellitus: A systematic review and meta-analysis.Journal of diabetes investigation · 2025Pooled it
- Association of Obstructive Sleep Apnea Syndrome (OSA/OSAHS) with Coronary Atherosclerosis Risk: Systematic Review and Meta-Analysis.Computational and mathematical methods in medicine · 2022Pooled it
- Cross-Sectional Analysis: Waist-to-Hip Ratio and Oxygen Saturation Association in Men Exposed to Long-Term Chronic Intermittent Hypobaric Hypoxia.Journal of clinical medicine · 2026Article
- Multifactorial relationships among the waist-to-hip ratio, insulin resistance, and obstructive sleep apnea in men: a large-scale cohort study.Nutrition & metabolism · 2025Article
- Predictive value of seven scoring systems for 28-day mortality in ICU patients with Sleep apnea-hypopnea syndrome (SAHS) and clinical indicators.European journal of medical research · 2025Article
- L-type calcium channel blockade worsens glucose tolerance and β-cell function in C57BL6/J mice exposed to intermittent hypoxia.American journal of physiology. Endocrinology and metabolism · 2025Article
- Impact of Early Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio Decrease After Continuous Positive Airway Pressure on Glycaemic Control in Type 2 Diabetes with Obstructive Sleep Apnea.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Contribution of glucose and glutamine to hypoxia-induced lipid synthesis decreases, while contribution of acetate increases, during 3T3-L1 differentiation.Scientific reports · 2024Article
- One Year Follow-Up Assessment of Impact of Rigorous Diet Regimen and Adequate C-PAP Therapy on Obese Patients with Obstructive Sleep Apnea Syndrome: A Retrospective Study.Journal of clinical medicine · 2024Article
- Association of obstructive sleep apnea symptoms with all-cause mortality and cause-specific mortality in adults with or without diabetes: A cohort study based on the NHANES.Journal of diabetes · 2024Article
- Effects of prolonged face mask use among patients with hypertension or diabetes during the COVID-19 pandemic.The Journal of international medical research · 2024Article
- Intermittent hypoxia increased the expression of ESM1 and ICAM-1 in vascular endothelial cells via the downregulation of microRNA-181a1.Journal of cellular and molecular medicine · 2024Article
- Association of Obstructive Sleep Apnea with Nonalcoholic Fatty Liver Disease: Evidence, Mechanism, and Treatment.Nature and science of sleep · 2024Review
- Neurotrophins in the Neuropathophysiology, Course, and Complications of Obstructive Sleep Apnea-A Narrative Review.International journal of molecular sciences · 2023Review
- New Metrics from Polysomnography: Precision Medicine for OSA Interventions.Nature and science of sleep · 2023Review
- A Review of the Associations Between Obstructive Sleep Apnea and Gestational Diabetes Mellitus and Possible Mechanisms of Disease.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- Upregulation of IL-8, osteonectin, and myonectin mRNAs by intermittent hypoxia via OCT1- and NRF2-mediated mechanisms in skeletal muscle cells.Journal of cellular and molecular medicine · 2022Article
- The Impact of Intermittent Hypoxia on Metabolism and Cognition.International journal of molecular sciences · 2022Review
- Upregulation ofInternational journal of molecular sciences · 2022Article
- Downregulation of the Cd38-Cyclic ADP-Ribose Signaling in Cardiomyocytes by Intermittent Hypoxia via Pten Upregulation.International journal of molecular sciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sleep apnea syndrome (SAS) is a very common disease involving intermittent hypoxia (IH), recurrent symptoms of deoxygenation during sleep, strong daytime sleepiness, and significant loss of quality of life. A number of epidemiological researches have shown that SAS is an important risk factor for insulin resistance and type 2 diabetes mellitus (DM), which is associated with SAS regardless of age, gender, or body habitus. IH, hallmark of SAS, plays an important role in the pathogenesis of SAS and experimental studies with animal and cellular models indicate that IH leads to attenuation of glucose-induced insulin secretion from pancreatic β cells and to enhancement of insulin resistance in peripheral tissues and cells, such as liver (hepatocytes), adipose tissue (adipocytes), and skeletal muscles (myocytes). In this review, we focus on IH-induced dysfunction in glucose metabolism and its underlying molecular mechanisms in several cells and tissues related to glucose homeostasis.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.