Trial reportScientific reports2019
Oxytocin modulates the temporal dynamics of resting EEG networks.
Trial report in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Utilization of EEG microstates as a prospective biomarker for assessing the impact of ketogenic diet in GLUT1-DS.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- EEG Microstates in Mood and Anxiety Disorders: A Meta-analysis.Brain topography · 2024Pooled it
- Tri-Phasic Model ofOxytocin (TRIO): A systematic conceptual review of oxytocin-related ERP research.Biological psychology · 2020Pooled it
- Effects of exogenous oxytocin and estradiol on resting-state functional connectivity in women and men.Scientific reports · 2023Trial
- EEG Microstate Correlates of Emotional Processing in Patients with Alcohol use Disorder and Healthy Controls: An Exploratory Resting-EEG Study.Brain topography · 2026Article
- Through Massage to the Brain-Neuronal and Neuroplastic Mechanisms of Massage Based on Various Neuroimaging Techniques (EEG, fMRI, and fNIRS).Journal of clinical medicine · 2026Review
- Abnormal Alterations in EEG Microstates and Functional Networks in Anti-LGI1 Antibody Encephalitis.Journal of inflammation research · 2025Article
- Unveiling Frequency-Specific Microstate Correlates of Anxiety and Depression Symptoms.Brain topography · 2024Article
- EEG Microstates in Social and Affective Neuroscience.Brain topography · 2024Review
- Article
- Current State of EEG/ERP Microstate Research.Brain topography · 2024Article
- EEG-Meta-Microstates: Towards a More Objective Use of Resting-State EEG Microstate Findings Across Studies.Brain topography · 2024Article
- Combined effects of neuroticism and negative emotional context on spontaneous EEG dynamics.Social cognitive and affective neuroscience · 2024Article
- Valence-specific EEG microstate modulations during self-generated affective states.Frontiers in psychology · 2024Article
- Oxytocin enhances the triangular association among behavior, resting-state, and task-state functional connectivity.Human brain mapping · 2023Article
- Sniffing oxytocin: Nose to brain or nose to blood?Molecular psychiatry · 2023Article
- Anxiety disrupts performance monitoring: integrating behavioral, event-related potential, EEG microstate, and sLORETA evidence.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Temporal Dynamics of Intranasal Oxytocin in Human Brain Electrophysiology.Cerebral cortex (New York, N.Y. : 1991) · 2022Review
- Relationship between Spatiotemporal Dynamics of the Brain at Rest and Self-Reported Spontaneous Thoughts: An EEG Microstate Approach.Journal of personalized medicine · 2021Article
- EEG microstate features according to performance on a mental arithmetic task.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxytocin is a key modulator of social interaction, but we possess little knowledge of its underlying effects on neuropsychological processes. We used a spatio-temporal EEG microstates analysis to reveal oxytocin's effects on the temporal dynamics of intrinsically generated activity in neural networks. Given oxytocin's known anxiolytic effects, we hypothesized that it increases the temporal stability of the four archetypal EEG resting networks. Eighty-six male participants had received oxytocin or placebo intranasally before we recorded their resting EEG. As hypothesized, oxytocin globally increased the average duration of the four archetypal resting networks and specifically decreased the occurrence and coverage of an autonomic processing-related network to benefit greater coverage of an attention-related network. Moreover, these neurophysiological changes were more pronounced in participants with high anxiety levels and strong subjectively experienced effects of the oxytocin administration. In sum, our study shows that oxytocin reduces rapid switching among neural resting networks by increasing their temporal stability. Specifically, it seems to reduce the brain's need for preparing the internally-oriented processing of autonomic information, thus enabling the externally-oriented processing of social information. Changes in the temporal dynamics of resting networks might underlie oxytocin's anxiolytic effects - potentially informing innovative psychobiological treatment strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.