Evidence mapPaperPMID 31568098Full record

ReviewMenopause (New York, N.Y.)2019

The menopause transition and women's health at midlife: a progress report from the Study of Women's Health Across the Nation (SWAN).

Samar R El Khoudary, Gail Greendale, Sybil L Crawford, Nancy E Avis, Maria M Brooks, Rebecca C Thurston, Carrie Karvonen-Gutierrez, L Elaine Waetjen, Karen Matthews

3 registry-linked trialsAbstract readReview
In one paragraph

Review in Menopause (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 234 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
234citing papers in PubMed, 9 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06975111 phase2 / phase3recruitingstarted 2026, after this paper: background citation

Focusing on the Menopausal Transition to Improve Mid-Life Women's Health

Ran2026Enrolled200Registered outcomes10Posted comparisons0ConditionsCardiovascular, Menopause, Menopause Hot Flashes, Menopause Related ConditionsArmsAnti-hypertensives, Fezolinetant, Hormonal therapy, Life Style Intervention, Lipid Lowering Medication
Open the trial in the graph
NCT05677698 nacompletednot on this mapstarted 2022, after this paper: background citation

Menoupausal Symptoms and Aromatherapy

TypeinterventionalSponsorKTO Karatay UniversityRan2022 to 2023Enrolled90ConditionsAromatherapyArmsLemon oil, peppermint oil, Almond oil
NCT07615777 narecruitingnot on this mapstarted 2026, after this paper: background citation

A Pilot Study Investigating the Effects of a Nutritional Supplement on Physiological and Metabolic Markers in 38-55-year-old Females

TypeinterventionalSponsorUniversity of SouthamptonRan2026 to 2026Enrolled80ConditionsPerimenopausal Women, Body Composition ChangesArmsNutritional Supplement, Placebo
3 · Its place in the literature

Who cites it

234 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  5. Effects of physical exercise on the lipid profile of perimenopausal and postmenopausal women: a systematic review and meta-analysis.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025
    Pooled it
  6. Pooled it
  7. Brazilian Guideline on Menopausal Cardiovascular Health - 2024.Arquivos brasileiros de cardiologia · 2024
    Guideline
  8. Pooled it
  9. Pooled it
  10. Trial
  11. Trial
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  14. Single-cell atlas of the mouse ovary reveals molecular drivers of aging and senescence during the estropausal transition.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  15. Review
  16. Endocrine modulation of cortical and retinal baseline perfusion across the menstrual cycle.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
  17. Article
  18. Article
  19. Article
  20. Article

174 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Samar R El KhoudaryDepartment of Epidemiology, Graduate School of Public Health University of Pittsburgh, Pittsburgh, PA.
Gail GreendaleDavid Geffen School of Medicine at UCLA, Los Angeles, CA.
Sybil L CrawfordUniversity of Massachusetts Medical School, Graduate School of Nursing, Worcester, MA.
Nancy E AvisDepartment of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, NC.
Maria M BrooksDepartment of Epidemiology, Graduate School of Public Health University of Pittsburgh, Pittsburgh, PA.
Rebecca C ThurstonDepartment of Epidemiology, Graduate School of Public Health University of Pittsburgh, Pittsburgh, PA.
Carrie Karvonen-GutierrezDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI.
L Elaine WaetjenDepartment of Obstetrics and Gynecology, University of California Davis School of Medicine, Sacramento, CA.
Karen MatthewsDepartment of Epidemiology, Graduate School of Public Health University of Pittsburgh, Pittsburgh, PA.

Funding

WOMENS HEALTH ACROSS THE NATION--PITTSBURGHU01AG012546 · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 1994 to 2005
$8.4M
WOMENS HEALTH ACROSS THE NATION--COORDINATING CENTERU01AG012553 · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 1994 to 2005
$7.8M
WOMENS HEALTH ACROSS THE NATION--ENDOCRINE LABU01AG012495 · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 1994 to 2005
$7.4M
WOMENS HEALTH ACROSS THE NATION--UCDAVISU01AG012554 · UNIVERSITY OF CALIFORNIA DAVIS · 1994 to 2005
$4.5M
WOMENS HEALTH ACROSS THE NATION--UCLAU01AG012539 · UNIVERSITY OF CALIFORNIA LOS ANGELES · 1994 to 2005
$4.5M
WOMENS HEALTH ACROSS THE NATION--CHICAGOU01AG012505 · RUSH UNIVERSITY MEDICAL CENTER · 1994 to 2005
$4.4M
Women's Health Across the Nation-New Jersey SiteU01AG012535 · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · 1994 to 2005
$4.0M
THE STUDY OF WOMEN'S HEALTH ACROSS THE NATION-MICHIGANU01NR004061 · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 1994 to 2005
$4.0M
WOMENS HEALTH ACROSS THE NATION--MASSACHUSETTS GENERAL HU01AG012531 · MASSACHUSETTS GENERAL HOSPITAL · 1994 to 2005
$3.3M
Pilot and Feasibility ProgramP30DK092926 · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2025 to 2025
$779k
NIA NIH HHS U01 AG012495NIA NIH HHS U01 AG012505NIA NIH HHS U01 AG012531NIA NIH HHS U01 AG012535NIA NIH HHS U01 AG012539NIA NIH HHS U01 AG012546NIA NIH HHS U01 AG012553NIA NIH HHS U01 AG012554NIDDK NIH HHS P30 DK092926NINR NIH HHS U01 NR004061
6 · The paper itself

Abstract

objectiveOur initial understanding of the menopause transition (MT) has been framed by clinical samples of women seeking treatment rather than by population-based studies. The Study of Women's Health Across the Nation (SWAN) initiated in 1996 with an overall goal to define the MT, to characterize its biological and psychosocial antecedents and sequelae in an ethnically and racially diverse sample of midlife women.

methodsThis review summarizes the central findings of SWAN to date that can inform women and their healthcare providers about the impact of the MT and midlife aging on overall health and well-being.

resultsSWAN characterized changes in reproductive axis and menstrual cycle patterns that informed the development of the reproductive aging staging system Staging of Reproductive Aging Workshop+10; MT-related symptoms and mental health (vasomotor symptoms, sleep complaints, psychological symptoms, cognitive performance, and urogenital and sexual health); and physiological systems and functions (cardiovascular and cardiometabolic health, bone health, physical function performance) that are influenced by the MT. SWAN demonstrated substantial interrelations among these changes and significant racial/ethnic differences in the rate and magnitude of change in multiple health indictors in midlife women. The findings point to midlife as a critical stage for adopting healthy behavior and preventive strategies.

conclusionsOver the past 23 years, SWAN has advanced our understanding of the impact of the MT and midlife aging on health and well-being in women. SWAN will be instrumental to determine whether MT-related changes during midlife are related to unfavorable health and well-being in early old age.

Indexed as

Health StatusWomen's HealthAdultAgedAgingEthnicityFemaleHot FlashesHumansMenopauseMental HealthMiddle AgedRacial GroupsResearch ReportSexual Health

Identifiers

PMID31568098
PMCPMC6784846

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.