Evidence map›Paper›PMID 31571239›Full record

SynthesisClinical cardiology2019

The association between hyperuricemia and coronary artery calcification development: A systematic review and meta-analysis.

Ling Liang, Xianghua Hou, Kevin R Bainey, Yanlin Zhang, Wayne Tymchak, Zhongquan Qi, Weihua Li, Hoan Linh Banh

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Gout, Uric Acid, and Coronary Artery Disease.Journal of atherosclerosis and thrombosis · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Ling LiangDepartment of Cardiology, The First Affiliated Hospital of Xiamen University, Xiamen, China.ORCID https://orcid.org/0000-0003-3772-6262
Xianghua HouDepartment of Nephrology, The First Affiliated Hospital of Xiamen University, Xiamen, China.ORCID https://orcid.org/0000-0002-6433-5374
Kevin R BaineyDivision of Cardiology, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada.ORCID https://orcid.org/0000-0003-0081-8649
Yanlin ZhangDepartment of Nephrology, The First Affiliated Hospital of Xiamen University, Xiamen, China.ORCID https://orcid.org/0000-0001-9107-8994
Wayne TymchakDivision of Cardiology, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada.ORCID https://orcid.org/0000-0003-3621-0520
Zhongquan QiInstitute of Organ Transplantation, Xiamen University, Xiamen, China.ORCID https://orcid.org/0000-0002-5414-9148
Weihua LiDepartment of Cardiology, The First Affiliated Hospital of Xiamen University, Xiamen, China.ORCID https://orcid.org/0000-0002-9344-8319
Hoan Linh BanhDepartment of Family Medicine, University of Alberta, Edmonton, Alberta, Canada.ORCID https://orcid.org/0000-0002-5976-7201
Fujian Medical University · CNUniversity of Alberta · CAXiamen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyperuricemia coincides with coronary artery calcification (CAC) development, but the role of serum uric acid (SUA) as a risk factor for CAC remains unclear. The objective of this study was to gain an insight into the association between SUA and CAC in adults by performing a meta-analysis. MEDLINE, EMBASE, the Cochrane Library, and EBSCO (CINAHL) were searched for relevant observational studies published until 2 June 2019. Studies were included only if they reported data on CAC presence (Agatston score > 0) or progression related to hyperuricemia in subclinical adult patients. The pooled estimates of crude and adjusted odds ratios (ORs) and 95% confidence interval (CI) were calculated to evaluate the association between CAC presence or progression and hyperuricemia. A total of 11 studies were identified involving 11 108 adults. The pooled OR based on the frequency of CAC presence showed that patients in the high SUA group had 1.806-fold risk for developing CAC (95% CI: 1.491-2.186) under the minimal threshold of hyperuricemia (more than 6 mg/dL or 357 μmoL/L). When SUA levels were analyzed as categorical variables, the pooled estimate of adjusted ORs was 1.48 (95% CI: 1.23-1.79) for CAC presence. Additionally, for each increase of 1 mg/dL of SUA level, the risk of CAC progression was increased by 31% (95% CI: 1.15-1.49) with an average follow-up duration ranged from 4.6 to 6.1 years. Hyperuricemia is closely associated with increased risk of CAC development and CAC progression in asymptomatic patients.

Indexed as

BiomarkersCoronary Artery DiseaseCoronary VesselsDisease ProgressionGlobal HealthHumansHyperuricemiaIncidenceRisk AssessmentRisk FactorsUric AcidVascular CalcificationBiomarkersUric Acidcoronary artery calcificationhyperuricemiameta-analysis

Identifiers

PMID31571239
PMCPMC6837029
OpenAlexW2977284791

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.