Evidence map›Paper›PMID 31572722›Full record

ReviewFrontiers in cell and developmental biology2019

Directing Traffic: Regulation of COPI Transport by Post-translational Modifications.

Peter M Luo, Michael Boyce

Abstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Cells · 2023
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Peter M LuoDepartment of Biochemistry, Duke University School of Medicine, Durham, NC, United States.
Michael BoyceDepartment of Biochemistry, Duke University School of Medicine, Durham, NC, United States.

Funding

Control of COPII vesicle trafficking by intracellular protein glycosylationR01GM117473 · NIGMS · DUKE UNIVERSITY · PI BOYCE, MICHAEL S · 2017 to 2025
$2.6M
Metabolic regulation of KLHL proteins through O-glycosylationR01NS111588 · NINDS · DUKE UNIVERSITY · PI BOYCE, MICHAEL S, CHI, JEN-TSAN ASHLEY · 2019 to 2022
$2.1M
NIGMS NIH HHS R01 GM117473NINDS NIH HHS R01 NS111588
6 · The paper itself

Abstract

The coat protein complex I (COPI) is an essential, highly conserved pathway that traffics proteins and lipids between the endoplasmic reticulum (ER) and the Golgi. Many aspects of the COPI machinery are well understood at the structural, biochemical and genetic levels. However, we know much less about how cells dynamically modulate COPI trafficking in response to changing signals, metabolic state, stress or other stimuli. Recently, post-translational modifications (PTMs) have emerged as one common theme in the regulation of the COPI pathway. Here, we review a range of modifications and mechanisms that govern COPI activity in interphase cells and suggest potential future directions to address as-yet unanswered questions.

Indexed as

coatomerCOPI vesicle traffickingglycosylationinterphasemyristoylationphosphorylationpost-translational modificationsubiquitination

Identifiers

PMID31572722
PMCPMC6749011

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.