ArticleNature and science of sleep2019
Benefit effect of REM-sleep deprivation on memory impairment induced by intensive exercise in male wistar rats: with respect to hippocampal BDNF and TrkB.
Article in Nature and science of sleep, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Investigating the effects of different exercise protocols on depressive-like behaviors and brain-derived neurotrophic factor (BDNF) in rodents: a systematic review.Experimental brain research · 2026Pooled it
- Imperatorin restores behavioral and recognition memory deficits induced by REM sleep deprivation in male rats.Scientific reports · 2026Article
- Dualistic and inconsistent role of total and rapid-eye movement (REM) sleep deprivation on depressive-like behaviors in rats: a systematic review.Sleep and biological rhythms · 2025Review
- Exploring Crocin's Role in Alleviating Memory Impairments and Depression-like Behaviors Induced by REM Sleep Deprivation, Focusing on BDNF and GSK-3β in Male Rats.Molecular neurobiology · 2025Article
- Altered brain-derived neurotrophic factor levels and oxidative stress in REM sleep deprivation: a rat model study.BMC neurology · 2025Article
- Effects of Quetiapine on Novelty-Related Object Recognition Memory and Hippocampal BDNF Level in Sleep-Deprived Rats.Brain and behavior · 2025Article
- Dexmedetomidine Alleviates Hippocampal Tissue Damage in Rapid Eye Movement Sleep-Deprived Rats by Activating BDNF/TrkB Signaling Pathway.Nature and science of sleep · 2025Article
- Article
- Chronic REM sleep deprivation leads to manic- and OCD-related behaviors, and decreases hippocampal BDNF expression in female rats.Psychopharmacology · 2024Article
- Efficacy of electroacupuncture stimulating Shenmen (HT7), Baihui (GV20), Sanyinjiao (SP6) on spatial learning and memory deficits in rats with insomnia induced by para-chlorophenylalanine: a single acupoint combined acupoints.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2023Article
- The Interaction Effect of Sleep Deprivation and Treadmill Exercise in Various Durations on Spatial Memory with Respect to the Oxidative Status of Rats.Neurochemical research · 2023Article
- The Devastating Effects of Sleep Deprivation on Memory: Lessons from Rodent Models.Clocks & sleep · 2023Review
- The consequences of sleep deprivation on cognitive performance.Neurosciences (Riyadh, Saudi Arabia) · 2023Review
- The role of sleep deprivation in streptozotocin-induced Alzheimer's disease-like sporadic dementia in rats with respect to the serum level of oxidative and inflammatory markers.Experimental brain research · 2022Article
- Myricetin prevents sleep deprivation-induced cognitive impairment and neuroinflammation in rat brainThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2022Article
- Butanol Extract of Tinospora cordifolia Alleviates Acute Sleep Deprivation-Induced Impairments in Cognitive Functions and Neuromuscular Coordination in Middle-Aged Female Rats.Neuromolecular medicine · 2022Article
- Effects of Treadmill Exercise on Social Behavior in Rats Exposed to Thimerosal with Respect to the Hippocampal Level of GluN1, GluN2A, and GluN2B.Journal of molecular neuroscience : MN · 2022Article
- Complicated Role of Exercise in Modulating Memory: A Discussion of the Mechanisms Involved.Neurochemical research · 2022Review
- Modulating role of serotonergic signaling in sleep and memory.Pharmacological reports : PR · 2022Review
- The effect of URB597, exercise or their combination on the performance of 6-OHDA mouse model of Parkinson disease in the elevated plus maze, tail suspension test and step-down task.Metabolic brain disease · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany factors affect our learning and memory quality, but according to different studies, having a positive or negative impact pertains to their characteristics like intensity or the amount. PURPOSE: The present study was conducted to investigate the effect of 24-hour REM-sleep deprivation on continuous-high intensity forced exercise-induced memory impairment and its effect on Brain-Derived Neurotrophic Factor (BDNF) and Tyrosine kinase B (TrkB) levels in the hippocampus and Prefrontal Cortex area (PFC). MATERIAL AND
methodsAnimals were conditioned to run on treadmills for 5 weeks then, were deprived of sleep for 24 h using the modified multiple platforms. The effect of intensive exercise and/or 24-h REM-SD was studied on behavioral performance using Morris Water Maze protocol for 2 days, and BDNF/TrkB levels were assessed in hippocampus and PFC after behavioral probe test using western blotting.
resultsAfter 5 weeks of intensive exercise and 24-h REM-SD, spatial memory impairment and reduction of BDNF and TrkB levels were found in hippocampus and PFC. 24-h REM-SD improved memory impairment and intensive exercise-induced downregulation of BDNF and TrkB protein levels.
conclusionThe results of the study suggested that sleep deprivation might act as a compensatory factor to reduce memory impairment when the animal is under severe stressful condition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.