Evidence map›Paper›PMID 31576370›Full record

ArticleTransplantation direct2019

Postdonation eGFR and New-Onset Antihypertensive Medication Use After Living Kidney Donation.

Krista L Lentine, Courtenay M Holscher, Abhijit S Naik, Ngan N Lam, Dorry L Segev, Amit X Garg, David Axelrod, Huiling Xiao, Macey L Henderson, Allan B Massie and 5 more

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In one paragraph

Article in Transplantation direct, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Krista L LentineSaint Louis University, St. Louis, MO.
Courtenay M HolscherJohns Hopkins University, Baltimore, MD.
Abhijit S NaikUniversity of Michigan, Ann Arbor, MI.
Ngan N LamUniversity of Alberta, Edmonton, AB, Canada.
Dorry L SegevJohns Hopkins University, Baltimore, MD.
Amit X GargWestern University, London, ON, Canada.
David AxelrodUniversity of Iowa, Iowa City, IA.
Huiling XiaoSaint Louis University, St. Louis, MO.
Macey L HendersonJohns Hopkins University, Baltimore, MD.
Allan B MassieJohns Hopkins University, Baltimore, MD.
Bertram L KasiskeHennepin Healthcare, Minneapolis, MN.
Gregory P HessUniversity of Pennsylvania, Philadelphia, PA.
Chi-Yuan HsuUniversity of California, San Francisco, San Francisco, CA.
Meyeon ParkUniversity of California, San Francisco, San Francisco, CA.
Mark A SchnitzlerSaint Louis University, St. Louis, MO.

Funding

Living Donor Extended Time Outcomes (LETO) StudyR01DK120551 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HSU, CHI-YUAN, LENTINE, KRISTA L · 2019 to 2023
$3.9M
Trajectory of post-donation renal function in living kidney donorsF32DK109662 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI HOLSCHER, COURTENAY · 2016 to 2018
$232k
NIDDK NIH HHS F32 DK109662NIDDK NIH HHS R01 DK120551
6 · The paper itself

Abstract

backgroundLimited data are available regarding clinical implications of lower renal function after living kidney donation. We examined a novel integrated database to study associations between postdonation estimated glomerular filtration rate (eGFR) and use of antihypertensive medication (AHM) treatment after living kidney donation.

methodsStudy data were assembled by linking national U.S. transplant registry identifiers, serum creatinine (SCr) values from electronic medical records, and pharmacy fill records for 3222 living donors (1989-2016) without predonation hypertension. Estimated GFR (mL/min per 1.73 m

resultsThe linked database identified an average of 3 postdonation SCr values per donor (range: 1-38). Lower postdonation eGFR (vs ≥75) bore graded associations with higher odds of AHM use (eGFR 30-44: aOR

conclusionsThis novel linkage illustrates the ability to identify postdonation kidney function and associate it with clinically meaningful outcomes; lower eGFR after living kidney donation is a correlate of AHM treatment requirements. Further work should define relationships of postdonation renal function, hypertension, and other morbidity measures.

Identifiers

PMID31576370
PMCPMC6708633

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.