Evidence map›Paper›PMID 31577152›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2020

Local angiotensin-(1-7) administration improves microvascular endothelial function in women who have had preeclampsia.

Anna E Stanhewicz, Lacy M Alexander

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Methods for analyzing acetylcholine-induced vasodilation in human skin.Journal of applied physiology (Bethesda, Md. : 1985) · 2026
    Article
  6. Review
  7. Article
  8. Reduced ATHypertension (Dallas, Tex. : 1979) · 2025
    Article
  9. Article
  10. Review
  11. Review
  12. VASCULAR AND RENAL MECHANISMS OF PREECLAMPSIA.Current opinion in physiology · 2023
    Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Maternal microvascular dysfunction during preeclamptic pregnancy.Clinical science (London, England : 1979) · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Anna E StanhewiczNoll Laboratory, Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania.
Lacy M AlexanderNoll Laboratory, Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania.
Pennsylvania State University · US

Funding

Essential Hypertension & Human Skin Blood FlowR01HL093238 · NHLBI · PENNSYLVANIA STATE UNIVERSITY, THE · PI ALEXANDER, LACY M. · 2009 to 2018
$4.3M
Role of Angiotensin II and Chronic Inflammation in Persistent Microvascular Dysfunction Following Preeclamptic PregnancyR00HL138133 · NHLBI · UNIVERSITY OF IOWA · PI STANHEWICZ, ANNA · 2019 to 2021
$747k
Role of Angiotensin II and Chronic Inflammation in Persistent Microvascular Dysfunction Following Preeclamptic PregnancyK99HL138133 · NHLBI · PENNSYLVANIA STATE UNIVERSITY, THE · PI STANHEWICZ, ANNA · 2018 to 2019
$213k
Microvascular Mechanisms Underlying Persistent Vessel Dysfunction Following PreeclampsiaF32HL129677 · NHLBI · PENNSYLVANIA STATE UNIVERSITY, THE · PI STANHEWICZ, ANNA · 2015 to 2017
$138k
NHLBI NIH HHS F32 HL129677NHLBI NIH HHS K99 HL138133NHLBI NIH HHS R00 HL138133NHLBI NIH HHS R01 HL093238
6 · The paper itself

Abstract

Despite remission of clinical symptoms postpartum, women who have had preeclampsia demonstrate microvascular endothelial dysfunction, mediated in part by increased sensitivity to angiotensin II (ANG II). Angiotensin-(1-7) [Ang-(1-7)] is an endogenous inhibitor of the actions of ANG II and plausible druggable target in women who had preeclampsia. We therefore examined the therapeutic potential of Ang-(1-7) in the microvasculature of women with a history of preeclampsia (PrEC;

Indexed as

Pre-EclampsiaAcetylcholineAngiotensin IEndothelium, VascularFemaleGene Expression Regulation, EnzymologicHumansMicrovesselsNitric Oxide SynthaseNitroprussidePeptide FragmentsPregnancyAcetylcholineAngiotensin Iangiotensin I (1-7)Nitric Oxide SynthaseNitroprussidePeptide Fragmentsangiotensin 1-7angiotensin IIendothelial dysfunctionmicrovascularpreeclampsia

Identifiers

PMID31577152
PMCPMC6985799
OpenAlexW2978238460

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.