Evidence map›Paper›PMID 31577477›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2020

Prenatal metyrapone treatment modulates neonatal cerebrovascular structure, function, and vulnerability to mild hypoxic-ischemic injury.

P Naomi Franco, Lara M Durrant, Desirelys Carreon, Elizabeth Haddad, Adam Vergara, Catherine Cascavita, Andre Obenaus, William J Pearce

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

P Naomi FrancoCenter for Perinatal Biology, Divisions of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, California.
Lara M DurrantCenter for Perinatal Biology, Divisions of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, California.
Desirelys CarreonCenter for Perinatal Biology, Divisions of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, California.
Elizabeth HaddadDepartment of Pediatrics, University of California, Irvine School of Medicine, Irvine, California.
Adam VergaraCenter for Perinatal Biology, Divisions of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, California.
Catherine CascavitaCenter for Perinatal Biology, Divisions of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, California.
Andre ObenausDepartment of Pediatrics, University of California, Irvine School of Medicine, Irvine, California.
William J PearceCenter for Perinatal Biology, Divisions of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, California.ORCID 0000-0002-5331-5677
Loma Linda University · USUniversity of California, Irvine · US

Funding

Uterine Vascular Adaptation to Pregnancy and Chronic HypoxiaP01HD083132 · NICHD · LOMA LINDA UNIVERSITY · PI ZHANG, LUBO · 2016 to 2020
$6.3M
Vascular Biology Core FacilityP01NS082184 · NINDS · LOMA LINDA UNIVERSITY · PI ZHANG, JOHN H · 2014 to 2018
$6.1M
Epigenetic Mechanisms of Developmental Regulation of Fetal, Newborn, and Adult Cerebral Artery Sympathetic Innervation and Alpha1 Adrenergic Receptor SubtypesR01HL135786 · NHLBI · LOMA LINDA UNIVERSITY · PI PEARCE, WILLIAM J., ZHANG, LUBO · 2017 to 2021
$2.0M
MATURATION OF CEREBROVASCULAR RELAXANT MECHANISMSR01HL064867 · NHLBI · LOMA LINDA UNIVERSITY · PI PEARCE, WILLIAM J. · 2000 to 2009
$1.8M
Cerebrovascular Myosin Light Chain Phosphorylation in Fetus, Newborn, and AdultR01NS076945 · NINDS · LOMA LINDA UNIVERSITY · PI PEARCE, WILLIAM J. · 2011 to 2015
$1.5M
MATURATION OF CEREBROVASCULAR CONTRACTILE MECHANISMSR01HL054120 · NHLBI · LOMA LINDA UNIVERSITY · PI PEARCE, WILLIAM J. · 1995 to 2005
$1.2M
Glucocorticoids and Programming of the Hypertensive Vascular PhenotypeR03HD054920 · NICHD · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI KHORRAM, OMID A. · 2007 to 2008
$140k
NHLBI NIH HHS R01 HL054120NHLBI NIH HHS R01 HL064867NHLBI NIH HHS R01 HL135786NICHD NIH HHS P01 HD083132NICHD NIH HHS R03 HD054920NINDS NIH HHS P01 NS082184NINDS NIH HHS R01 NS076945
6 · The paper itself

Abstract

This study explored the hypothesis that late gestational reduction of corticosteroids transforms the cerebrovasculature and modulates postnatal vulnerability to mild hypoxic-ischemic (HI) injury. Four groups of Sprague-Dawley neonates were studied:

Indexed as

AnimalsAnimals, NewbornCarotid ArteriesCerebrovascular DisordersFemaleHypoxiaHypoxia-Ischemia, BrainLigationPregnancyPrenatal CarePyridinesRatsRats, Sprague-DawleymetapyronePyridines11β-hydroxylasecerebral histopathologycerebrovascular smooth muscle phenotypefetal programmingneonatal corticosterone

Identifiers

PMID31577477
PMCPMC6985796
OpenAlexW2977568747

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.