ArticleMolecular genetics & genomic medicine2019
Gene-level genome-wide association analysis of suicide attempt, a preliminary study in a psychiatric Mexican population.
Article in Molecular genetics & genomic medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Genomic Studies of Suicidal Thoughts and Behaviors in Latin American Populations: A Systematic Review.Biological psychiatry · 2026Pooled it
- Genome-wide association study meta-analysis of suicide death and suicidal behavior.Molecular psychiatry · 2023Pooled it
- Genetics and epigenetics of self-injurious thoughts and behaviors: Systematic review of the suicide literature and methodological considerations.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2022Pooled it
- Regulator of G protein signaling 10: a critical regulator of chronic systemic inflammation in parkinson's disease.Journal of neuroinflammation · 2026Review
- Pharmacogenes Associated with Suicidal Behavior: Addressing a Potential Therapeutic Window.Actas espanolas de psiquiatria · 2026Review
- Psychiatric genetics in the diverse landscape of Latin American populations.Nature genetics · 2025Review
- Using the Strategy of Genome-Wide Association Studies to Identify Genetic Markers of Suicidal Behavior: A Narrative Review.Consortium psychiatricum · 2024Review
- Evolutionary conservation of putative suicidality-related risk genes that produce diminished motivation corrected by clozapine, lithium and antidepressants.Frontiers in psychiatry · 2024Article
- High Serum Levels of IL-6 Are Associated with Suicide Attempt but Not with High Lethality Suicide Attempts: A Preliminary Case-Control Study.International journal of environmental research and public health · 2022Article
- Identification of potential blood biomarkers associated with suicide in major depressive disorder.Translational psychiatry · 2022Article
- Catalytic Reaction Model of Suicide.Frontiers in psychiatry · 2022Review
- Genetic contributions to suicidal thoughts and behaviors.Psychological medicine · 2021Review
- Investigation of de novo mutations in a schizophrenia case-parent trio by induced pluripotent stem cell-based in vitro disease modeling: convergence of schizophrenia- and autism-related cellular phenotypes.Stem cell research & therapy · 2020Article
- Gene-level genome-wide association analysis of suicide attempt, a preliminary study in a psychiatric Mexican population.Molecular genetics & genomic medicine · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEvidence suggests that liability for suicide behavior is heritable; additionally, suicide has been partly related to other psychiatric disorders. Nevertheless, most of the information reported so far address Caucasian and Asian individuals. Hence, our aim was to conduct a gene-level association study in Mexican psychiatric individuals diagnosed with suicide attempt.
methodsWe recruited 192 individuals from two clinical centers in Mexico. All participants were born in Mexico and had Mexican parents and grandparents. Direct genotyping was performed using the commercial platform Infinium PsychArray BeadChip. A p-value lower than 1e-05 was considered as gene-level significant and a p-value lower than 1e-04 was considered as gene-level nominal significant.
resultsOur analyses showed that SCARA5 was associated to suicide intent at a gene-level with statistical significance (p-value = 1.12e-6). Other genes were nominally associated with suicide attempt: GHSR (p-value = 0.0004), RGS10 (p-value = 5.13e-5), and STK33 (p-value = 3.62e-5). Regarding gene variant analyses, the SNPs with a statistical association (p > .05) were rs561361616, rs1537577, rs11198999 for RGS10, and rs11041981, rs11041993, rs11041994, rs11041995, rs11041997, rs10840083, rs10769918 for STK33. For these genes, previous studies have associated SCARA5 with depression, GHSR with alcohol dependence and depression, and RGS10 with schizophrenia and depression. To date, STK33 has not been associated with any psychiatric disorder.
conclusionOur outcomes revealed that SCARA5, GHSR, RGS10 and STK33 could be considered as risk biomarkers for suicide attempt behavior in our Mexican psychiatric sample. We recommend to perform larger scale analyses to have conclusive results.
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