Evidence map›Paper›PMID 31580077›Full record

ArticleThe journal of physical chemistry. B2019

In Silico Investigation of the Binding of MCoTI-II Plant Defense Knottin to the γ-NGF Serine Protease of the 7S Nerve Growth Factor Complex and Biological Activity of Its NGF Mimetic Properties.

Peter M Jones, Elizabeth Mazzio, Karam Soliman, Anthony M George

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physical chemistry. B, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Peter M JonesSchool of Life Sciences , University of Technology Sydney , P.O. Box 123, Broadway , New South Wales 2007 , Australia.
Elizabeth MazzioCollege of Pharmacy and Pharmaceutical Sciences , Florida Agricultural and Mechanical University , 241 Fred Humphries Science Research Facility , Tallahassee , Florida 32307 , United States.
Karam SolimanCollege of Pharmacy and Pharmaceutical Sciences , Florida Agricultural and Mechanical University , 241 Fred Humphries Science Research Facility , Tallahassee , Florida 32307 , United States.
Anthony M GeorgeSchool of Life Sciences , University of Technology Sydney , P.O. Box 123, Broadway , New South Wales 2007 , Australia.ORCID 0000-0003-4691-8960
Florida Agricultural and Mechanical University · USUniversity of Technology Sydney · AU

Funding

THE PREVENTION OF B(A)P INDUCED CELL TRANSFORMATION BY ORGANOSULFUR COMPOUNDSG12RR003020 · NCRR · FLORIDA AGRICULTURAL AND MECHANICAL UNIV · PI DARLING-REED, SELINA FAITH · 1985 to 2011
$29.7M
Research Project-3: Effectiveness of an eHealth intervention for uptake of cervical cancer screening in Hispanic womenU54MD007582 · NIMHD · FLORIDA AGRICULTURAL AND MECHANICAL UNIV · PI Seth Y Ablordeppey · 2019 to 2026
$28.1M
NCRR NIH HHS G12 RR003020NIMHD NIH HHS U54 MD007582
6 · The paper itself

Abstract

Nerve growth factor (NGF) is an endogenously produced polypeptide that promotes the differentiation, survival, and repair of neurons in the central and peripheral nervous systems. While trophic proteins hold promise for the treatment of neuronal injury and disease, use of NGF is limited by its large molecular weight, lack of permeability through the blood-brain barrier, and peripheral side effects. Previously, we found that an extract of the

Indexed as

Neuronal OutgrowthAnimalsBiomimeticsComputer SimulationCyclotidesCystine-Knot MiniproteinsMolecular Dynamics SimulationMomordicaNerve Growth FactorsPC12 CellsPlant ExtractsProtein BindingProtein ConformationRatsSerine Endopeptidases7S nerve growth factor complexCyclotidesCystine-Knot Miniproteinsnerve growth factor, gammaNerve Growth FactorsPlant ExtractsSerine Endopeptidasestrypsin inhibitor MCoTI-II

Identifiers

PMID31580077
PMCPMC7749518
OpenAlexW2977450355

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.