Evidence map›Paper›PMID 31585047›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Formyl peptide receptor 2 regulates monocyte recruitment to promote intestinal mucosal wound repair.

Dorothee Birkl, Monique N O'Leary, Miguel Quiros, Veronica Azcutia, Matthew Schaller, Michelle Reed, Hikaru Nishio, Justin Keeney, Andrew S Neish, Nicholas W Lukacs and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 50 citations in OpenAlex.

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  19. Maresin-2 promotes mucosal repair and has therapeutic potential when encapsulated in thermostable nanoparticles.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Dorothee BirklDepartment of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
Monique N O'LearyDepartment of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
Miguel QuirosDepartment of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
Veronica AzcutiaDepartment of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
Matthew SchallerDepartment of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
Michelle ReedDepartment of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
Hikaru NishioDepartment of Pathology, Emory University, Atlanta, Georgia, USA.
Justin KeeneyDepartment of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
Andrew S NeishDepartment of Pathology, Emory University, Atlanta, Georgia, USA.
Nicholas W LukacsDepartment of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
Charles A ParkosDepartment of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
Asma NusratDepartment of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
University of Michigan–Ann Arbor · USEmory University · US

Funding

University of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MERCHANT, JUANITA L. · 1986 to 2021
$22.5M
Regulation of intestinal epithelial barrier function by intercellular junction proteins in health and diseaseR01DK059888 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ASMA NUSRAT · 2001 to 2026
$10.5M
Intestinal Mucosal Wound Resealing in IBDR01DK055679 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ASMA NUSRAT · 2004 to 2026
$8.1M
Intestinal Inflammation: Signaling proteins and the rate of PMN transmigrationR01DK079392 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PARKOS, CHARLES A · 2007 to 2025
$7.2M
Neutrophil Interactions with Intestinal Epithelial CellsR01DK072564 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PARKOS, CHARLES A · 2005 to 2020
$6.5M
Structure-Function Studies on Intestinal Epithelial JAMR01DK061379 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PARKOS, CHARLES A · 2002 to 2021
$6.3M
Formyl peptide receptors as mediators of intestinal mucosal homeostasisR01DK089763 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NEISH, ANDREW S, NUSRAT, ASMA · 2011 to 2020
$4.7M
Formyl peptide receptors as mediators of intestinal mucosal homeostasisR56DK089763 · NIDDK · EMORY UNIVERSITY · PI NEISH, ANDREW S, NUSRAT, ASMA · 2010 to 2010
$741k
INTESTINAL MUCOSAL WOUND RESEALING IN SURGICAL DISEASESR29DK055679 · NIDDK · EMORY UNIVERSITY · PI NUSRAT, ASMA · 1998 to 2002
$324k
NIDDK NIH HHS P30 DK034933NIDDK NIH HHS R01 DK055679NIDDK NIH HHS R01 DK059888NIDDK NIH HHS R01 DK061379NIDDK NIH HHS R01 DK072564NIDDK NIH HHS R01 DK079392NIDDK NIH HHS R01 DK089763NIDDK NIH HHS R29 DK055679NIDDK NIH HHS R56 DK089763
6 · The paper itself

Abstract

Mucosal wound repair is coordinated by dynamic crosstalk between endogenous and exogenous mediators and specific receptors on epithelial cells and infiltrating immune cells. One class of such receptor-ligand pairs involves formyl peptide receptors (FPRs) that have been shown to influence inflammatory response and repair. Here we explored the role of murine Fpr2/3, an ortholog of human FPR2/receptor for lipoxin A4 (ALX), in orchestrating intestinal mucosal repair. Compared with wild-type (WT) mice,

Indexed as

Cell MovementWound HealingAnimalsBone Marrow TransplantationChemokine CCL20ColitisDextran SulfateInflammationIntestinal MucosaMaleMiceMice, Inbred C57BLMice, KnockoutMonocytesReceptors, CCR6Receptors, Formyl PeptideCCL20 protein, mouseCCR6 protein, mouseChemokine CCL20Dextran Sulfateformyl peptide receptor 2, mouseFpr3 protein, mouseReceptors, CCR6Receptors, Formyl PeptideepitheliumFPR2GPCRsinflammationinflammatory bowel disease

Identifiers

PMID31585047
PMCPMC6894067
OpenAlexW2978440466

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.