ArticleJournal of lipid research2019
Decreased ω-6:ω-3 PUFA ratio attenuates ethanol-induced alterations in intestinal homeostasis, microbiota, and liver injury.
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In one paragraph
Article in Journal of lipid research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 6% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Impact of Omega-3 Polyunsaturated Fatty Acids on Alcohol Use and Negative Consequences: A Systematic Review.Nutrition reviews · 2025Pooled it
- Gut microbiome responses to dietary intervention with hypocholesterolemic vegetable oils.NPJ biofilms and microbiomes · 2022Trial
- Hepatoprotective effects of resolvin D1 in mice exposed to ethanol and galactosamine.Hepatology communications · 2026Article
- Eicosapentaenoic acid enhances intestinal stem cell-mediated colonic epithelial regeneration by activating the LSD1-WNT signaling pathway.Journal of advanced research · 2025Article
- Plant-Derived Nutraceuticals in Mental Health and Brain Function: Mechanisms of Action and Therapeutic Potential.International journal of molecular sciences · 2025Review
- Exploring the Role of Polyunsaturated Fatty Acids in Children's Sleep.Biomedicines · 2025Review
- Effects of Different Rearing Methods on the Intestinal Morphology, Intestinal Metabolites, and Gut Microbiota of Lueyang Black-Bone Chickens.Animals : an open access journal from MDPI · 2025Article
- Heavy metals, noradrenaline/adrenaline ratio, and microbiome-associated hormone precursor metabolites: biomarkers for social behaviour, ADHD symptoms, and executive function in children.Scientific reports · 2025Article
- Adrenic acid: A promising biomarker and therapeutic target (Review).International journal of molecular medicine · 2025Review
- Leaky Gut Syndrome: An Interplay Between Nutrients and Dysbiosis.Current nutrition reports · 2025Review
- Insight into the effects of Omega-3 fatty acids on gut microbiota: impact of a balanced tissue Omega-6/Omega-3 ratio.Frontiers in nutrition · 2025Review
- Potential of nutraceuticals in celiac disease.Tissue barriers · 2025Review
- Omega-3 fatty acids: multi-target mechanisms and therapeutic applications in neurodevelopmental disorders and epilepsy.Frontiers in nutrition · 2025Review
- Gut-liver axis: Recent concepts in pathophysiology in alcohol-associated liver disease.Hepatology (Baltimore, Md.) · 2024Review
- Variations in the milk lipidomic profile of lactating dairy cows fed the diets containing alfalfa hay versus alfalfa silage.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Article
- The Role of Gut Microbiome in Sleep Quality and Health: Dietary Strategies for Microbiota Support.Nutrients · 2024Review
- Sex-Specific Effect of Ethanol on Colon Content Lipidome in a Mice Model Using Nontargeted LC/MS.ACS omega · 2024Article
- Article
- Omega-3-Rich Fish-Oil-Influenced Mouse Gut Microbiome Shaped by Intermittent Consumption of Beef.Current microbiology · 2023Article
- Immunomodulatory effect of marine lipids on food allergy.Frontiers in nutrition · 2023Review
Corrections and comments
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Authors and funding
19 authors at 4 institutions in 1 country.
Dennis R WarnerDepartment of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Louisville, Louisville, KY.ORCID 0000-0002-5303-6870
Jeffrey B WarnerDepartment of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Louisville, Louisville, KY.
Josiah E HardestyDepartment of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Louisville, Louisville, KY.
Ying L SongDepartment of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Louisville, Louisville, KY.
Taylor N KingDepartment of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Louisville, Louisville, KY.
Jing X KangLaboratory for Lipid Medicine and Technology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Chih-Yu ChenLaboratory for Lipid Medicine and Technology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Shanfu XieLaboratory for Lipid Medicine and Technology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Fang YuanDepartment of Chemistry, University of Louisville, Louisville, KY.
Md Aminul Islam ProdhanDepartment of Chemistry, University of Louisville, Louisville, KY.
Xipeng MaDepartment of Chemistry, University of Louisville, Louisville, KY.
Xiang ZhangDepartment of Chemistry, University of Louisville, Louisville, KY.
Eric C RouchkaDepartment of Computer Engineering and Computer Science, Speed School of Engineering, University of Louisville, Louisville, KY.
Krishna Rao MaddipatiDepartment of Pathology, Wayne State University School of Medicine, Detroit, MI.
Joan WhitlockDepartment of Medicine Division of Infectious Diseases and Global Medicine, College of Medicine, University of Florida, Gainesville, FL.
Eric C LiDepartment of Medicine Division of Infectious Diseases and Global Medicine, College of Medicine, University of Florida, Gainesville, FL.
Gary P WangDepartment of Medicine Division of Infectious Diseases and Global Medicine, College of Medicine, University of Florida, Gainesville, FL.
Craig J McClainDepartment of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Louisville, Louisville, KY.
Irina A KirpichDepartment of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Louisville, Louisville, KY i0kirp01@louisville.edu.
University of Louisville · USHarvard University · USUniversity of Florida · USWayne State University · US
Funding
WKU Lead Faculty AwardP20GM103436 · NIGMS · UNIVERSITY OF LOUISVILLE · PI Bruce A Mattingly · 2012 to 2026
$60.1MRole of oxidized linoleic acid metabolites in the pathogenesis of alcoholic liver diseaseP20GM113226 · NIGMS · UNIVERSITY OF LOUISVILLE · PI HOOD, JOSHUA L. · 2016 to 2025
$24.1MThe Role of Nutrition in the Development/Progression of Alcohol-Induced Organ InjuryP50AA024337 · NIAAA · UNIVERSITY OF LOUISVILLE · PI CRAIG J. MCCLAIN · 2016 to 2026
$17.9MNovel Therapies for Alcoholic HepatitisU01AA021893 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI MCCLAIN, CRAIG J., MCCULLOUGH, ARTHUR JOSEPH · 2012 to 2017
$6.0MPILOT PROJECT PROGRAMP30GM106396 · NIGMS · UNIVERSITY OF LOUISVILLE · PI MILLER, DONALD M. · 2013 to 2017
$5.4MThe role of dietary unsaturated fat and inflammasome in alcoholic liver diseaseR01AA024102 · NIAAA · UNIVERSITY OF LOUISVILLE · PI KIRPICH, IRINA A. · 2016 to 2020
$1.7MOxidized Metabolites of Linoleic Acid in Alcohol-induced Liver InjuryU01AA022489 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FELDSTEIN, ARIEL, MCCLAIN, CRAIG J. · 2014 to 2018
$1.7MMechanisms for alcohol induced gut barrier dysfunction in ALDR01AA023681 · NIAAA · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2014 to 2018
$1.6MNovel therapies in alcoholic hepatitis University of LouisvilleU01AA021901 · NIAAA · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2012 to 2017
$1.5MUltra Performance Liquid Chromatography High Resolution High Mass Accuracy Mass SpectrometerS10OD020106 · OD · UNIVERSITY OF LOUISVILLE · PI ZHANG, XIANG · 2015 to 2015
$600kTriple Quadrupole - Ion Trap Hybrid LC/MS/MS SystemS10RR027926 · NCRR · WAYNE STATE UNIVERSITY · PI MADDIPATI, KRISHNARAO · 2010 to 2010
$425kRvD1-FPR2 signaling ameliorates alcoholic liver diseaseF32AA027950 · NIAAA · UNIVERSITY OF LOUISVILLE · PI HARDESTY, JOSIAH E · 2020 to 2022
$164kBLRD VA I01 BX000350NCRR NIH HHS S10 RR027926NIAAA NIH HHS F31 AA028423NIAAA NIH HHS F32 AA027950NIAAA NIH HHS L30 AA027913NIAAA NIH HHS P50 AA024337NIAAA NIH HHS R01 AA023681NIAAA NIH HHS R01 AA024102NIAAA NIH HHS U01 AA021893NIAAA NIH HHS U01 AA021901NIAAA NIH HHS U01 AA022489NIGMS NIH HHS P20 GM103436NIGMS NIH HHS P20 GM113226NIGMS NIH HHS P30 GM106396NIH HHS S10 OD020106
Abstract
Ethanol (EtOH)-induced alterations in intestinal homeostasis lead to multi-system pathologies, including liver injury. ω-6 PUFAs exert pro-inflammatory activity, while ω-3 PUFAs promote anti-inflammatory activity that is mediated, in part, through specialized pro-resolving mediators [e.g., resolvin D1 (RvD1)]. We tested the hypothesis that a decrease in the ω-6:ω-3 PUFA ratio would attenuate EtOH-mediated alterations in the gut-liver axis. ω-3 FA desaturase-1 (
Indexed as
AnimalsBile Acids and SaltsEthanolFatty Acids, Omega-3Fatty Acids, Omega-6FecesFemaleGastrointestinal MicrobiomeHomeostasisIntestinal MucosaLipopolysaccharidesMiceMice, Inbred C57BLBile Acids and SaltsEthanolFatty Acids, Omega-3Fatty Acids, Omega-6Lipopolysaccharidesalcoholic liver diseasebile acid metabolismdiet and dietary lipidsgut microbiomeinflammationintestineomega-3 fatty acidspolyunsaturated fatty acid
Identifiers
What Socratic holds
Textmetadata
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.