Evidence map›Paper›PMID 31591827›Full record

ArticlePhysiological reports2019

A role for PKD1 in insulin secretion downstream of P2Y

Shara Khan, Mourad Ferdaoussi, Austin Bautista, Valérie Bergeron, Nancy Smith, Vincent Poitout, Patrick E MacDonald

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Protein kinase D1 - A targetable mediator of pancreatic cancer development.Biochimica et biophysica acta. Molecular cell research · 2024
    Review
  4. Review
  5. miR-4431 targets TRIP10/PRKD1 and impairs glucose metabolism.Journal of diabetes investigation · 2022
    Article
  6. Pharmacogenetics of Type 2 Diabetes-Progress and Prospects.International journal of molecular sciences · 2020
    Review
  7. Obesity ofDiabetes, metabolic syndrome and obesity : targets and therapy · 2020
    Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Shara KhanDepartment of Pharmacology and Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.
Mourad FerdaoussiDepartment of Pharmacology and Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.
Austin BautistaDepartment of Pharmacology and Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.
Valérie BergeronDépartement de Médecine, Université de Montréal, Montréal, Quebec, Canada.
Nancy SmithDepartment of Pharmacology and Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.
Vincent PoitoutDépartement de Médecine, Université de Montréal, Montréal, Quebec, Canada.
Patrick E MacDonaldDepartment of Pharmacology and Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0002-5439-6288
University of Alberta · CACentre Hospitalier de l’Université de Montréal · CA

Funding

CIHR 148451CIHR 86545CIHR MOP 148451CIHR MOP 86545
6 · The paper itself

Abstract

Along with insulin, β-cells co-secrete the neurotransmitter ATP which acts as a positive autocrine signal via P2Y

Indexed as

AnimalsFemaleHumansInsulinInsulin-Secreting CellsInsulin SecretionIslets of LangerhansMaleMiceMice, Inbred C57BLProtein Kinase CReceptors, Purinergic P2Y1Signal TransductionInsulinProtein Kinase Cprotein kinase DReceptors, Purinergic P2Y1ATPBMIinsulinP2Y1PKD1β cells

Identifiers

PMID31591827
PMCPMC6779929
OpenAlexW2980041106

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.