Evidence map›Paper›PMID 31592053›Full record

ArticleJournal of clinical biochemistry and nutrition2019

Anti-obesity effects of α-cyclodextrin-stabilized 4-methylthio-3-butenyl isothiocyanate from daikon (

Hinako Okamoto, Syoko Ino, Nanako Nihei, Naoko Ikuta, Chihiro Ueno, Aya Itoi, Yutaka Yoshikawa, Keiji Terao, Norihiro Sakamoto

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical biochemistry and nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Hinako OkamotoDepartment of Social/Community Medicine and Health Science, Food and Drug Evaluation Science, Graduate School of Medicine, Kobe University, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan.
Syoko InoDepartment of Health, Sports, and Nutrition, Faculty of Health and Welfare, Kobe Woman's University, 4-7-2 Minatojima-nakamachi, Chuo-ku, Kobe, Hyogo 650-0046, Japan.
Nanako NiheiCycloChem Bio Co., Ltd., 7-4-5 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan.
Naoko IkutaDepartment of Social/Community Medicine and Health Science, Food and Drug Evaluation Science, Graduate School of Medicine, Kobe University, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan.
Chihiro UenoCycloChem Bio Co., Ltd., 7-4-5 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan.
Aya ItoiDepartment of Health, Sports, and Nutrition, Faculty of Health and Welfare, Kobe Woman's University, 4-7-2 Minatojima-nakamachi, Chuo-ku, Kobe, Hyogo 650-0046, Japan.
Yutaka YoshikawaDepartment of Health, Sports, and Nutrition, Faculty of Health and Welfare, Kobe Woman's University, 4-7-2 Minatojima-nakamachi, Chuo-ku, Kobe, Hyogo 650-0046, Japan.
Keiji TeraoDepartment of Social/Community Medicine and Health Science, Food and Drug Evaluation Science, Graduate School of Medicine, Kobe University, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan.
Norihiro SakamotoDepartment of Social/Community Medicine and Health Science, Food and Drug Evaluation Science, Graduate School of Medicine, Kobe University, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan.
Institute of Bioorganic Chemistry · BYKobe University · JPKobe Women's University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

4-Methylthio-3-butenyl isothiocyanate (MTBI) is a pungent bioactive constituent found in daikon. However, MTBI is immediately hydrolyzed to 3-hydroxy-methylene-2-thioxopyrrolidine in grated daikon. In this study, we evaluated whether MTBI in grated daikon complexed with α-cyclodextrin (αCD) has anti-obesity effects in mice. C57BL/6J mice were fed a normal diet (normal group), high-fat diet (HFD, control group), HFD with αCD (αCD group), or HFD with MTBI-αCD (MTBI-αCD group) for 16 weeks. The results showed that the final body weight, epididymal white adipose tissue weight, and plasma triglyceride and total cholesterol levels were significantly lower in the MTBI-αCD group than in the control group. The cell size in epididymal adipose tissue was significantly smaller and the accumulation of lipids in the liver was significantly lower in the MTBI-αCD group than in the control group. Furthermore, real-time polymerase chain reaction showed that the mRNA expression level of tumor necrosis factor-alpha was suppressed in the MTBI-αCD group. We also observed low superoxide dismutase activity in the MTBI-αCD group, possibly because MTBI-αCD has the potential to resist HFD-induced oxidative injury. In conclusion, MTBI-αCD exerted anti-inflammation and antioxidant effects to suppress lipid accumulation in epididymal adipose tissue and the liver. These effects then prevented HFD-induced obesity in mice.

Indexed as

4-methylthio-3-butenyl isothiocyanateanti-obesity effectantioxidant effecthigh-fat dietαCD

Identifiers

PMID31592053
PMCPMC6769408
OpenAlexW2967249428

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.