ArticleSocial cognitive and affective neuroscience2019
Cognitive reserve-mediated neural modulation of emotional control and regulation in people with late-life depression.
Article in Social cognitive and affective neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Meta-analysis of neural correlates of working memory, reward, and emotion processing in major depressive disorder using AES-SDM.BMC psychiatry · 2026Pooled it
- Meta-analysis of neural correlates of working memory, reward, and emotion processing in major depressive disorder using ALE.Psychological medicine · 2026Pooled it
- Review of EEG-based neurofeedback as a therapeutic intervention to treat depression.Psychiatry research. Neuroimaging · 2023Pooled it
- Structural and functional neuroimaging of late-life depression: a coordinate-based meta-analysis.Brain imaging and behavior · 2022Pooled it
- How to promote healthy ageing among disabled older adults: from a group difference perspective and function-specific pathway models.International journal for equity in health · 2026Article
- Protective Effects of Genetic Proxies of Cognitive Reserve in Parkinson's Disease: A Longitudinal Multi-Cohort Study.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- A data-driven cluster analysis to explore cognitive reserve and modifiable risk factors in early phases of cognitive decline.Scientific reports · 2025Article
- Cognitive engagement may slow clinical progression and brain atrophy in Huntington's disease.Scientific reports · 2024Article
- Cognitive reserve modulates mental health in adulthood.Aging clinical and experimental research · 2024Article
- Neural Functioning in Late-Life Depression: An Activation Likelihood Estimation Meta-Analysis.Geriatrics (Basel, Switzerland) · 2024Review
- Review of Emotion Regulation in Late Life Mood Disorders.Journal of psychiatry and brain science · 2024Article
- The need to change: Is there a critical role of midlife adaptation in mental health later in life?eLife · 2023Review
- Shared Risk Factors for Depressive Disorder Among Older Adult Couples in Korea.JAMA network open · 2023Article
- Development of inferiority-compensation scale among high school students.BMC medical education · 2023Article
- Editorial: Maintain that brain - protecting and boosting cognitive flexibility.Frontiers in human neuroscience · 2023Article
- Musical experience prior to traumatic exposure as a resilience factor: a conceptual analysis.Frontiers in psychology · 2023Review
- Prefrontal reactivity to TMS perturbation as a toy model of mental health outcomes during the COVID-19 pandemic.Heliyon · 2022Article
- Altered Intrinsic Brain Activity in Patients With Late-Life Depression: A Resting-State Functional MRI Study.Frontiers in psychiatry · 2022Article
- TMS-Evoked Prefrontal Perturbation as a Toy Model of Brain Resilience to Stress During the COVID-19 Pandemic.Research square · 2021Article
- Cognitive Reserve as a Protective Factor of Mental Health in Middle-Aged Adults Affected by Chronic Pain.Frontiers in psychology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Late-life depression (LLD) is an affective disorder that is highly prevalent among older people. Cognitive reserve (CR) refers to an active process that facilitates the flexibility and efficiency of the neural networks to compensate for impairments that emerge in consequence of brain pathology. The current functional magnetic resonance imaging study investigated whether and how CR affects emotional regulation, level of depression severity and neural activity associated with affective control during emotional Stroop (eStroop) task. Altogether, 90 older people participated in this study, 50 of whom suffered from LLD. We used years of education and verbal fluency capacity as proxies for CR. Clinical participants with relatively higher CR presented with milder degrees of depression, better eStroop performance and stronger neural activity in the middle frontal gyrus (MFG) involved with exercising affective control. Results of the mediation analysis indicated that both education and verbal fluency significantly mediated the association between the depression severity and MEG activity. These results suggest a negative association between CR and age-related clinical symptoms of emotional dysregulation. Our neurobehavioral findings provide supportive evidence that CR implies efficiency of top-down emotional regulation and operates as a protective factor against emotional and cognitive vulnerability in the aging brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.