ReviewFrontiers in endocrinology2019
Mechanisms Underlying Type 2 Diabetes Remission After Metabolic Surgery.
Review in Frontiers in endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Impact of metabolic and bariatric surgery on the paediatric & adolescent metabolome: A systematic review and meta-analysis.Scientific reports · 2025Pooled it
- Metabolic heterogeneity after laparoscopic sleeve gastrectomy in type 2 diabetes mellitus patients with severe obesity: insights from continuous glucose monitoring, glycemic profiles and quality of life.Acta diabetologica · 2026Observational
- Type 2 diabetes mellitus remission 10 years after metabolic and bariatric surgery: a multicenter retrospective study in Poland (BARI‑10‑POL).Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2026Article
- The effect of gastrojejunostomy on carbohydrate metabolism in patients with pancreatic cancer.Przeglad gastroenterologiczny · 2026Article
- Type 2 diabetes mellitus: Isn't it time to update the terminology?World journal of diabetes · 2025Review
- The Influence of Bariatric Surgery on Reproductive Hormones and Ovarian Morphology and Clinical Findings in Women: A Prospective Study.Obesity surgery · 2025Article
- Remission of type 2 diabetes: position statement of the Italian society of diabetes (SID).Acta diabetologica · 2024Article
- Article
- Single anastomosis duodeno-ileal bypass with sleeve gastrectomy generates sustained improvement of glycemic control compared with sleeve gastrectomy in the diet-induced obese rat model.Journal of physiology and biochemistry · 2024Article
- Sleeve gastrectomy causes weight-loss independent improvements in hepatic steatosis.Liver international : official journal of the International Association for the Study of the Liver · 2023Article
- An Imbalance of Pathophysiologic Factors in Late Postprandial Hypoglycemia Post Bariatric Surgery: A Narrative Review.Obesity surgery · 2023Review
- The role of diabetes severity scores in predicting disease remission in patients with BMI > 50 kg/mSurgical endoscopy · 2023Article
- Gut Microbiome and Associated Metabolites Following Bariatric Surgery and Comparison to Healthy Controls.Microorganisms · 2023Article
- Gastric bypass surgery weight loss-independently induces gut Il-22 release in association with improved glycemic control in obese Zucker fatty rats.Metabolism open · 2023Article
- Article
- Review
- Weight Loss and Gastrointestinal Hormone Variation Caused by Gastric Artery Embolization: An Updated Analysis Study.Frontiers in endocrinology · 2022Review
- Multi-omic phenotyping reveals host-microbe responses to bariatric surgery, glycaemic control and obesity.Communications medicine · 2022Article
- Article
- A Comparative Study of the Effect of Two Procedures of Classic Roux-en-Y and Omega Bariatric Surgery on the Control and Management of Diabetes.Advanced biomedical research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Type 2 diabetes prevalence is increasing dramatically worldwide. Metabolic surgery is the most effective treatment for selected patients with diabetes and/or obesity. When compared to intensive medical therapy and lifestyle intervention, metabolic surgery has shown superiority in achieving glycemic improvement, reducing number of medications and cardiovascular risk factors, which translates in long-term benefits on cardiovascular morbidity and mortality. The mechanisms underlying diabetes improvement after metabolic surgery have not yet been clearly understood but englobe a complex interaction among improvements in beta cell function and insulin secretion, insulin sensitivity, intestinal gluconeogenesis, changes in glucose utilization, and absorption by the gut and changes in the secretory pattern and morphology of adipose tissue. These are achieved through different mediators which include an enhancement in gut hormones release, especially, glucagon-like peptide 1, changes in bile acids circulation, gut microbiome, and glucose transporters expression. Therefore, this review aims to provide a comprehensive appraisal of what is known so far to better understand the mechanisms through which metabolic surgery improves glycemic control facilitating future research in the field.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.